Diabetes in the KK mouse

Dulin, W. E.; Wyse, B. M.

doi:10.1007/bf01212245

Cited by 50 publications

(29 citation statements)

References 11 publications

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“…in obese hyperglycemic mice [12] and KK-mice [7]. In the sandrat there is an initial increase and a subsequent fall of the serum insulin level attributed to pancreatic exhaustion [15].…”

Section: Discussionmentioning

confidence: 99%

Ob�sit� et hyperplasie des �lots du pancr�as chez la gerbille mongolienne

Boquist

1972

Diabetologia

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Summary. In a colony of Mongolian gerbils maintained on a standard laboratory diet, occasional obese animals were found. Obesity developed in animals of both sexes and was either transitory or permanent. The mean fasting blood glucose level in non-obese and obese gerbils was 83 and 105 rag/100 ml, respectively. Glucosuria and hyperglycemia were found only in a few obese animals, whereas the glucose tolerance was decreased in most obese gerbils. --The endocrine pancreas of the obese animals was morphologically either normal or more often hyperplastic, sometimes with the appearance of adenomatous islets. The fl-eells possessed prominent Golgi complex and endoplasmic reticulum, and sparse granulation. Large, granule-poor cells and mitotic figures were seen in the islets. Degenerative changes occurred in the fl-cells of diabetic animals. --It is suggested that the maintenance of the gerbils under laboratory conditions with free access to laboratory diet plays a majo r role in the development of obesity and that the endocrine pancreas of these animals has a good capacity for hyperplasia that often is sufficient to maintain normo-glycemia in obese animals, although the glucose tolerance is decreased. Obdsit@ et hyperplasie des ilots du panerdas chez la gerbille mongolienneRdsumd. Dans un 61evage de gerbilles mongoliennes soumises ~ un r@gime standard de laboratoire ont dr@ parfois trouvds des animaux ob@ses. L~ se dgveloppait chez les animaux des deux sexes et 6tait tantSt transitoire, tant6t permanente. Le taux moyen de glucose du sang, ~ jefin, ehez les animaux non ob@ses et ob~-ses 6tait respectivement de 83 et 105 mg/100 ml. La glyeosurie et l'hyperglycdmie n'dtaient trouvdes que ehez peu d'animaux ob6ses, tandis que la toldrance au glucose 6tait rdduite ehez la plupart des animaux ob@ses. --Le pancrdas endocrine des animaux ob@ses dtait, morphologiquement, normal ou plus souvent hyperplasique avec parfois l'apparition d'ilots adgnomateux. Les eellules /~ poss@daient un eomplexe de Golgi et un rdticulum endoplasmique pro@minents et une granulation faible. De grosses eellules pauvres en granules et des figures mitotiques se montraient dans les ilots. Des changements d@gdndratifs se produisaient dans les cellules fl des animaux diab6tiques. --On sugg~re que le maintien des animaux darts les conditions de laboratoire avec libre acc@s au r@gime de laboratoire joue un r61e prddominant darts le d@veloppement de I'ob@sit@ et que le pancr@as endocrine de ces animaux a une excellente eapaeit6 d'hyperplasie qu! suffit souvent ~ maintenir la normoglycdmie ehez les ammaux ob@ses, malgr6 la r6duction de la tol6rance au glucose. ~]bergewieht und Hyperplasie der Pankreasinseln bei der mongolischen RennmausZusammenfassung.

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“…in obese hyperglycemic mice [12] and KK-mice [7]. In the sandrat there is an initial increase and a subsequent fall of the serum insulin level attributed to pancreatic exhaustion [15].…”

Section: Discussionmentioning

confidence: 99%

Ob�sit� et hyperplasie des �lots du pancr�as chez la gerbille mongolienne

Boquist

1972

Diabetologia

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“…There are many reports about diabetic neuropathy in several animal models of streptozotocin or alloxaninduced diabetes [1,33], transgenic mice which developed islet cell adenoma [8], spontaneous IDDM [23,30,31] and NIDDM [3,7,9,10,29,30]. To elucidate the mechanisms of peripheral nerve damage in diabetic neuropathy, various animal models have been studied [1,8,16,19,23,29,32,34], whereas there are few accounts in the literature of spontaneous animal models of peripheral neuropathy with progressive NIDDM [30].…”

Section: Discussionmentioning

confidence: 99%

Diabetic Complications in a New Animal Model (TSOD mouse) of Spontaneous NIDDM with Obesity

et al. 2005

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“…Hyperphagia, hyperglycemia, hyperinsulinemia, obesity and intermittent glueosuria have been found in the Toronto-KK (T-KK) mouse [1,2], a strain obtained by inbreeding offspring of a cross between KK and C57BL/6J strains of mice [1]. More recently insulin insensitivity, abnormal glucose tolerance and abnormal gluconeogenesis have been added to the list of disorders found in these mice and all abnormalities have become less severe in one year old mice [3].…”

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confidence: 99%