Diabetes in pregnancy: Effect on glycation and acetylation of the different chains of fetal and maternal hemoglobin

Davison, Andrew S.; Green, B.N.; Roberts, Norman B.

doi:10.1016/j.clinbiochem.2010.09.015

Cited by 5 publications

(7 citation statements)

References 21 publications

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“…Regarding the geographical distribution, the review included seven studies from Europe [30][31][32][33][34][35][36], seven studies from Asia [37][38][39][40][41][42][43] and two studies from Latin America [44,45]. Thirteen of these studies employed case-control design [30,32,33,[35][36][37][38][39][40][41][42][43][44] whereas the rest three studies were cross-sectional in design [31,34,45]. Specifically, the meta-analysis of AGEs involved 774 cases and 834 controls.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The systematic review and meta-analysis involved studies that reported the outcome measures at both first and second trimesters [32], first and third trimesters [36], second trimester [30,31,34,41,44], second and third trimesters [38,42], and third trimester of pregnancy [33,35,37,39,40] whereas two studies did not specify gestational period during sample collection [43,45]. Blood sample was collected from 13 studies [30,31,33,[35][36][37][38][39][40][42][43][44][45], skin sample from two studies [32,34], and placenta sample from one study [41] ( Table 1). For analysis of specific AGEs and metabolic biomarkers, five and four studies were included to generate the pooled estimates of HOMA-IR [31,37,42,43,45], and HbA1c [31,33,37,43], respectively.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Blood sample was collected from 13 studies [30,31,33,[35][36][37][38][39][40][42][43][44][45], skin sample from two studies [32,34], and placenta sample from one study [41] ( Table 1). For analysis of specific AGEs and metabolic biomarkers, five and four studies were included to generate the pooled estimates of HOMA-IR [31,37,42,43,45], and HbA1c [31,33,37,43], respectively. Three studies with four effect measures (including one repeated measure at two gestational time points) were included for ICAM-1/VCAM-1 analysis [39,40,45] (Table 2).…”

Section: Study Characteristicsmentioning

confidence: 99%

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The relationship between advanced glycation end products and gestational diabetes: A systematic review and meta-analysis

et al. 2020

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Introduction Gestational Diabetes Mellitus (GDM) is a condition in which women without history of diabetes experience hyperglycemia during pregnancy, especially at the second and third trimesters. In women who have had GDM, an elevated body mass index (BMI) may have a substantial impact for persistent hyperglycemia in their lives after gestation. Beyond hyperglycemia, increased local oxidative stress directly promotes the formation of Advanced Glycation End-products (AGEs). Hence, this systematic review and meta-analysis was aimed to determine the relationship between the level of AGEs and/or related metabolic biomarkers with GDM. Methods Literature search was carried out through visiting electronic databases, indexing services, and directories including PubMed/MEDLINE (Ovid ®), EMBASE (Ovid ®), google scholar and WorldCat to retrieve studies without time limit. Following screening and eligibility evaluation, relevant data were extracted from included studies and analyzed using Rev-Man 5.3 and STATA 15.0. Inverse variance method with random effects pooling model was used for the analysis of outcome measures at 95% confidence interval. Hedge's adjusted g statistics was applied to calculate the standardized mean difference (SMD) to consider the small sample bias. Besides, meta-regression, meta-influence, and publication bias analyses were conducted. The protocol has been registered on PROSPERO with ID: CRD42020173867. Results A total of 16 original studies were included for the systematic review and meta-analysis.

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Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

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The relationship between advanced glycation end products and gestational diabetes: A systematic review and meta-analysis

et al. 2020

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“…Assay of the Hb variant samples needs to be carried out by a reference laboratory, but it's almost impossible, unfortunately. Besides reference assay procedure, the best way is to use affinity chromatography as no interference is observed or to use electro spray ionisation ESIMS procedure where the different Hb chains can be identified and the relative glycations computed [26][27][28].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Interference of Hemoglobin Variant J-Bangkok on Glycated Hemoglobin (HbA1c) Measurement by Five Different Methods

Wen

Wang

et al. 2017

Exp Clin Endocrinol Diabetes

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The interference of the hemoglobin variant (Hb J-Bangkok) was evaluated on 4 different glycated hemoglobin assays and compared with a reference immuno assay. An overall test of coincidence of 2 least-squares linear regression lines was performed to determine whether the presence of Hb J-Bangkok caused a statistically significant difference in HbA1c results compared with a reference immuno assay. Statistical analysis was performed on the difference of the estimated average glucose calculated from HbA1c values and fasting plasma glucose in the Hb J-Bangkok variant group using the different detection systems. Deming regression analysis was used to determinate whether Hb J-Bangkok had a significant interference on HbA1c results using an HbA1c±10% relative bias at 6% and 9% HbA1c as evaluation limits. Turbidimetric inhibition immunoassay method, and enzymatic methods were not affected by Hb J-Bangkok. However, Hb J-Bangkok showed statistically significant interference to the two ion-exchange high-performance liquid chromatography methods. When performing HbA1c tests, clinical laboratory personnel should identify the Hb variant and select the appropriate methods or use alternative indicators.

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“…Hb F, some of which is glycated (2 ), accounts for the majority (70%-95%) of Hb species in newborns. About 5%-30% is Hb A, with none to trace amounts of Hb A 1c .…”

Section: Answersmentioning

confidence: 99%

A Diabetic Newborn?

2014

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Diabetes in pregnancy: Effect on glycation and acetylation of the different chains of fetal and maternal hemoglobin

Cited by 5 publications

References 21 publications

The relationship between advanced glycation end products and gestational diabetes: A systematic review and meta-analysis

The relationship between advanced glycation end products and gestational diabetes: A systematic review and meta-analysis

Evaluation of the Interference of Hemoglobin Variant J-Bangkok on Glycated Hemoglobin (HbA1c) Measurement by Five Different Methods

A Diabetic Newborn?

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