Diabetes, coeliac disease, multiple sclerosis and chronic arthritis in first‐degree relatives of patients with juvenile idiopathic arthritis

Abstract

Autoimmune diseases cluster in families with a child with JIA.

HLA genotyping as first-line screening tool for coeliac disease in children with juvenile idiopathic arthritis

“…In our cohort, overall prevalence of autoimmune disorders in relatives was significantly increased, consistent with data from previous studies 6 24 25. But in contrast to those studies, which found the highest prevalence in the oligoarticular group, we found the highest prevalence in the psoriatic arthritis group, followed by the enthesitis-associated group and then by the oligoarticular group, as a result of a different composition of the study populations.…”

The autoimmune burden in juvenile idiopathic arthritis

“…Prahalad et al [18] underlined how AITD were the most frequent associated diseases while Huang et al [19] revealed also the presence of psoriasis, ankylosing spondylitis and SLE. Pohjankoski et al [20] studied the presence of IDDM, CD, MS and chronic arthritis in 355 families of JIA patients showing an overall prevalence of 21.4%. The data of a large cohort of patients in the United States have recently been published [21] showing that the prevalence of autoimmunity is increased among the relatives of JIA subjects compared to those of JDM with a greater proportion of inflammatory arthritis.…”

CD226 (DNAM-1) is associated with susceptibility to juvenile idiopathic arthritis

“…It has become increasingly clear that autoimmune diseases cluster in individuals and families 14 15. In line with this, genetic variations have been identified that are associated with more than one autoimmune disease, like rheumatoid arthritis (RA), type 1 diabetes mellitus, autoimmune thyroid disease, inflammatory bowel disease, systemic lupus erythematosus, multiple sclerosis, and also JIA 16 – 20.…”