Diabetes, Cardiovascular Morbidity, and Risk of Age-Related Macular Degeneration in a Primary Care Population

Vassilev, Zdravko P.; Ruigómez, Ana; Soriano‐Gabarró, Montse; Rodrı́guez, Luis A. Garcı́a

doi:10.1167/iovs.14-16271

Cited by 40 publications

(27 citation statements)

References 45 publications

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“…Hyman et al [116] and the BMES [117] reported significant associations between AMD and a history of CVD. The AREDS [118] and another BMES [119] found advanced AMD to associate with increased cardiovascular deaths, while the BMES (2008) also found early AMD to associate with increased CVD mortality.…”

Section: Epidemiology Of Cardiovascular Health and Amdmentioning

confidence: 99%

“…Duan et al [120] and Vassilev et al [119] reported that AMD significantly associated with increased risk of myocardial infarction (MI). The Atherosclerosis Risk in Communities Study (ARCS, [121]) observed a significant association between late AMD and incident CHD in a population at high risk for CHD.…”

Section: Epidemiology Of Cardiovascular Health and Amdmentioning

confidence: 99%

“…The ALIENOR study [149] reported a significant association between elevated HDL-C levels and early or any AMD. Furthermore, Vassilev et al [119] reported an increased risk of AMD for patients with hyperlipidemia.…”

Section: Epidemiology Of Cardiovascular Health and Amdmentioning

confidence: 99%

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Epidemiology of age-related macular degeneration (AMD): associations with cardiovascular disease phenotypes and lipid factors

2016

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Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in adults over 50 years old. Genetic, epidemiological, and molecular studies are beginning to unravel the intricate mechanisms underlying this complex disease, which implicate the lipid-cholesterol pathway in the pathophysiology of disease development and progression. Many of the genetic and environmental risk factors associated with AMD are also associated with other complex degenerative diseases of advanced age, including cardiovascular disease (CVD). In this review, we present epidemiological findings associating AMD with a variety of lipid pathway genes, cardiovascular phenotypes, and relevant environmental exposures. Despite a number of studies showing significant associations between AMD and these lipid/cardiovascular factors, results have been mixed and as such the relationships among these factors and AMD remain controversial. It is imperative that researchers not only tease out the various contributions of such factors to AMD development but also the connections between AMD and CVD to develop optimal precision medical care for aging adults.

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Section: Epidemiology Of Cardiovascular Health and Amdmentioning

confidence: 99%

Section: Epidemiology Of Cardiovascular Health and Amdmentioning

confidence: 99%

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Epidemiology of age-related macular degeneration (AMD): associations with cardiovascular disease phenotypes and lipid factors

2016

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“…The most common pathologies responsible for visual impairment and blindness are age-related macular degeneration, glaucoma and diabetic retinopathy. Major eye diseases which result in loss of vision or blindness are age-related macular degeneration (ARMD), diabetic retinopathy, cataracts, and glaucoma [12][13][14] . There are general causes of sudden loss of vision i.e.…”

Section: Cell Replacement Therapy For Optic Nerve Disordersmentioning

confidence: 99%

Cell Replacement Therapy for Optic Nerve Disorders

Upadhyay¹,

Internationals²

2017

JSRB

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This review article explains major optic nerve disorders and cell replacement therapy. This article also signifies new innovative methods, biopharmaceuticals, implantable biomaterials, devices and diagnostic tools developed for restoration of vision. It asserts notable technological advancements made for regeneration of neurons and restoration of visual system network. However, for finding quick solutions of optical-neuronal disorders more advanced biomaterial cell scaffolds and concurrent efforts are needed to revitalize visual-neural receptor system. This article stresses upon novel bioengineered methods mainly required to activate endogenous stem and progenitor cells, which could reawaken cells in dormancy, instructing them to promote repair and regeneration in optic nerve cells and retina. For better management of optic nerve disorders, important role of tissues, genes, growth factors and proteins, nano-medicine and nanotechnology, and all underlying mechanisms should fully investigated. This article tries to explore all possibilities to find quick solutions for treatment of loss of vision/ photoreceptors and degeneration of optic neural network despite all ongoing challenges. Moreover, for solving visual disorders, neurodegenerative blinding diseases novel cell-based therapeutic strategies are to be developed with future applications in regenerative medicine.

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“…We also hypothesized that the link observed in large populationbased studies between inflammatory markers seen in ischemic cardiovascular disease and neovascular AMD may play a role. 4,5 Given the suspicion by Kim regarding the possible association of macular hemorrhages and visual outcomes, we reanalyzed our cohort and reviewed 147 eyes of 128 patients that had 2 years of treat-and-extend follow-up. The 14 eyes of patients taking clopidogrel were compared with the 133 eyes of patients who had not.…”

mentioning

confidence: 99%