Diabetes as a risk factor for acute coronary syndrome in women compared with men: a meta‐analysis, including 10 856 279 individuals and 106 703 acute coronary syndrome events

Xue, Dong; Cai, Rongrong; Sun, Jie; Huang, Rong; Wang, Pin; Sun, Hao; Tian, Sai; Wang, Shaohua

doi:10.1002/dmrr.2887

Cited by 30 publications

(27 citation statements)

References 87 publications

(171 reference statements)

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“…Individuals with T2DM have a 2 to 3-fold greater risk of CVD than people without T2DM, with women showing an increased elevated risk compared to men (2.5 fold risk increase in women compared to 1.7-fold in men) (41). Moreover, people with T2DM have an increased risk of long-term mortality following coronary revascularization in both stable ischemic and ACS populations (42–46).…”

Section: Resultsmentioning

confidence: 99%

Blood Sugar Regulation for Cardiovascular Health Promotion and Disease Prevention

Schwarz

Timpel

Harst

et al. 2018

Journal of the American College of Cardiology

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The primary objective of this study is to analyze the most up-to-date evidence regarding whether and how blood sugar regulation impacts cardiovascular health promotion and disease prevention by carrying out an umbrella review. Three separate, systematic literature searches identified a total of 2,343 articles. Overall, 44 studies were included for data extraction and analysis. The included systematic reviews and meta-analyses published between 1 January 2016 and 31 December 2017 were of good to very good quality (median OQAQ score = 17). Identified evidence suggests that cardiovascular prevention services should consider the regulation of blood glucose as a key target for intervention. Furthermore, CV prevention should adopt the recommendations for effective intervention and service development/training described in this review in existing evidence-based practice guidelines. Multidisciplinary teams should be formed to deliver multi-component interventions in community-based settings. There may be substantial opportunities for integrating CVD prevention and diabetes prevention services.

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Section: Resultsmentioning

confidence: 99%

Blood Sugar Regulation for Cardiovascular Health Promotion and Disease Prevention

Schwarz

Timpel

Harst

et al. 2018

Journal of the American College of Cardiology

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“…Diet quality is important for individuals with diabetes mellitus. The American Diabetes Association recommends “healthful eating patterns, emphasizing a variety of nutrient-dense foods” to help “attain individual glycemic, blood pressure, and lipid goals” and to “delay or prevent the complication of diabetes.” [1] With regard to complications of diabetes, and in particular cardiovascular disease (CVD) outcomes, which are more common in those with diabetes [2, 3], emerging data underscore the importance of dietary pattern for those with diabetes. In observational studies focusing on participants with diabetes at baseline, a higher quality diet was associated with decreased rates of CVD events and CVD mortality [4] and total mortality [5].…”

Section: Introductionmentioning

confidence: 99%

Diet quality trends among adults with diabetes by socioeconomic status in the U.S.: 1999–2014

et al. 2019

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Background The diet quality of adults living in the United States has improved overtime. We aim to determine whether diet quality among adults with diabetes mellitus has changed over time, and to examine trends in socioeconomic disparities in diet quality. Methods Repeated cross-sectional analysis of eight National Health and Nutrition Examination Survey (NHANES) cycles (1999–2000 through 2013–2014). We included 5882 adult participants (age 20 or older) with diabetes mellitus (type 1 or 2) who completed 24-h dietary recalls. Diet quality was measured by the Healthy Eating Index 2010 (HEI) score (range 0–100, higher scores indicate better diet quality). We tested whether there were differences in diet quality across education, income, and food security categories, and whether any differences changed over time, using weighted linear regression models accounting for the complex survey design and adjusted for age, gender, and race/ethnicity. Results Twenty nine percent of US adults with diabetes had less than a high school diploma, 17% had income < 100% of federal poverty level, and 15% reported food insecurity. Average adjusted HEI score increased from 49.4 to 52.4 over the study period (p for trend = 0.003). We observed differences in HEI between high and low education (4.1, 95% CI 3.0–5.3), high and low income (3.7, 95%CI 2.4–5.0) and food secure relative to food insecure (2.1, 95% CI 0.8–3.3). These differences did not improve over time for education ( p = 0.56), income ( p = 0.65) or food security ( p = 0.39) categories. Conclusions Diet quality for adults with diabetes in the U.S. has improved overall; however, substantial disparities exist and have not improved. A concerted effort to improve diet quality in vulnerable groups may be needed. Electronic supplementary material The online version of this article (10.1186/s12902-019-0382-3) contains supplementary material, which is available to authorized users.

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“…Previous studies have shown that coronary atherosclerotic plaque rupture, vasospasm and consequent platelet adhesion, aggregation, and secondary thrombosis are the main pathophysiological mechanisms of ACS [10, 11]. Additionally, diabetes [12], hypertension [13], obesity [14], smoking [15], and older age [16] are risk factors that promote the development and progression of ACS. A large number of studies have indicated that inflammatory factors are also closely related to ACS.…”

Section: Introductionmentioning

confidence: 99%

Baseline Serum Uric Acid Levels Are Associated with All-Cause Mortality in Acute Coronary Syndrome Patients after Percutaneous Coronary Intervention

Lü

Long

et al. 2018

Disease Markers

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Background Whether serum uric acid (UA) is associated with all-cause mortality in patients with acute coronary syndrome (ACS) following percutaneous coronary intervention (PCI) remains unclear. Methods We performed a retrospective cohort study of 2296 patients with ACS. Curve-fitting and Cox proportional-hazard regression models with a hazard ratio (HR) and 95% confidence interval (CI) were used. Results During a mean follow-up of 246.31 ± 49.16 days, 168 (7.32%) patients died from all causes. Patients were divided into two groups [the high-UA group (n = 566) and the low-UA group (n = 1730)] based on the serum UA threshold value (5.6 mg/dl) identified through curve fitting. Fifty-three (9.36%) patients died in the high-UA group, and 115 (6.65%) patients died in the low-UA group. The difference between groups was statistically significant (P = 0.031). Univariate analysis showed that the risk of all-cause mortality in the high-UA group was significantly greater than that in the low-UA group (HR = 1.45, 95% CI: 1.03 to 2.04). This difference persisted after adjustment for baseline characteristics, medical history, and medication history (HR = 1.42, 95% CI: 1.05 to 1.87). Conclusions Our study demonstrated that elevated serum UA (>5.6 mg/dl) is associated with all-cause mortality in ASC patients after PCI.

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Diabetes as a risk factor for acute coronary syndrome in women compared with men: a meta‐analysis, including 10 856 279 individuals and 106 703 acute coronary syndrome events

Abstract: The excess risk of ACS associated with diabetes is significantly higher in women than in men. This finding may be explained by more adverse cardiovascular risk profiles and suggests that further work is needed to clarify the relevant biological, behavioural, and social mechanisms.

Cited by 30 publications

References 87 publications

Blood Sugar Regulation for Cardiovascular Health Promotion and Disease Prevention

Blood Sugar Regulation for Cardiovascular Health Promotion and Disease Prevention

Diet quality trends among adults with diabetes by socioeconomic status in the U.S.: 1999–2014

Baseline Serum Uric Acid Levels Are Associated with All-Cause Mortality in Acute Coronary Syndrome Patients after Percutaneous Coronary Intervention

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