Diabetes as a Pancreatic Microvascular Disease—A Pericytic Perspective
Luciana Mateus Gonçalves,
Catarina Andrade Barboza,
Joana Almaça
Abstract:Diabetes is not only an endocrine but also a vascular disease. Vascular defects are usually seen as consequence of diabetes. However, at the level of the pancreatic islet, vascular alterations have been described before symptom onset. Importantly, the cellular and molecular mechanisms underlying these early vascular defects have not been identified, neither how these could impact the function of islet endocrine cells. In this review, we will discuss the possibility that dysfunction of the mural cells of the mi… Show more
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