Diabetes and thyroid disorders

Brenta, Gabriela

doi:10.1177/1474651410371321

Cited by 52 publications

(45 citation statements)

References 56 publications

(64 reference statements)

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“…18,19,20 Unrecognized dyslipidemia may increase cardiovascular risk. The increased frequency of dyslipidemia in thyroid hypofunction calls for a systematic approach to lipid profiling.…”

Section: Discussionmentioning

confidence: 99%

Lipid profile alterations and fasting blood glucose levels in primary hypothyroidism

et al. 2014

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“…18,19,20 Unrecognized dyslipidemia may increase cardiovascular risk. The increased frequency of dyslipidemia in thyroid hypofunction calls for a systematic approach to lipid profiling.…”

Section: Discussionmentioning

confidence: 99%

Lipid profile alterations and fasting blood glucose levels in primary hypothyroidism

et al. 2014

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“…Thyroid hormone, which is related to the regulation of glucose homeostasis, acts synergistically with insulin [4]. Fetal and postnatal neuronal development is closely related to thyroid hormone action [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Hypothyroid States Mitigate the Diabetes-Induced Reduction of Calbindin D-28k, Calretinin, and Parvalbumin Immunoreactivity in Type 2 Diabetic Rats

et al. 2011

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In this study, we investigated the differences in calbindin D-28k (CB), calretinin, (CR) and parvalbumin (PV) immunoreactivity in the hippocampus of Zucker diabetic fatty (ZDF) rats and Zucker lean control (ZLC) rats. In addition, we observed the effects of hypothyroidism on the levels of immunoreactivity of these proteins in ZDF rats. For this study, 7-week-old ZDF rats were used, and methimazole treatment was continued for 5 weeks to induce hypothyroidism. The animals were sacrificed at 12 weeks of age. ZDF rats showed increased blood glucose levels compared to those in ZLC rats. Methimazole intervention significantly reduced total and free T3 levels, and it ameliorated the increase of blood glucose levels in ZDF rats. In ZLC rats, CB, CR, and PV immunoreactivity was detected in regions of the hippocampus proper. In vehicle-treated ZDF rats, CB, CR, and PV immunoreactivity was significantly decreased in the hippocampus. However, in the methimazole-treated rats, CB, CR, and PV immunoreactivity was significantly increased compared to that in the vehicle-treated rats. These results suggest that hypothyroidism ameliorated the diabetes-induced reduction of CB, CR, and PV immunoreactivity in the hippocampus.

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“…Hypothyroidism is characterized by insulin resistance. 1 In type2 DM patients the presence of highly frequent subclinical forms of hyperthyroidism and hypothyroidism should be ruled out since they may be associated with increased risk of nephropathy, retinopathy and cardiovascular events. 2 The prevalence of subclinical hypothyroidism is higher in patients with metabolic syndrome which can be explained by concomitance of deranged serum lipid concentration, obesity, hypertension, insulin resistance in both these conditions.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of thyroid dysfunction in patients with Type 2 diabetes mellitus and its correlation with insulin resistance and serum markers for autoimmune thyroiditis

et al. 2015

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Background:The term "THYROID DIABETES" was coined in early literature to depict the influence of thyroid hormone excess in deterioration of glucose control. Although autoimmune thyroid disease is more prevalent in Type1 Diabetes mellitus as a result of their common origin, the prevalence of hypothyroidism and hyperthyroidism is supposed to be similar to that of general population in patient with type2 DM. The purpose of the study was to evaluate the prevalence of thyroid dysfunction in patients with type2 diabetes mellitus and to correlate thyroid abnormalities with insulin resistance and serum markers for autoimmune thyroiditis. Methods: 120 cases of type2 diabetes mellitus patients satisfying WHO criteria without pre-existing thyroid disease were included in the study. Thyroid function test, fasting serum insulin was done.HOMA-IR & HOMA-B (HOMA-Homeostatic model assessment) was calculated. Serum antithyroid peroxidase anibody (anti-TPO) and antithyroglobulin antibodies (anti-TG) and ANA were done. Results: Prevalence of thyroid dysfunction in type2 diabetes mellitus was 28.33% according to our study, which included overt hypothyroidism (15%), subclinical hypothyroidism (8.33%), secondary hypothyroidism (0.83%), overt hyperthyroidism (1.67%) and subclinical hyperthyroidism (2.5%). Anti TPO and anti TG antibodies were elevated in 62.07% cases of hypothyroidism, 40% cases of hyperthyroidism and 6.9% euthyroid cases of type2 DM. Anti TPO and antiTG antibodies were significantly raised in type2DM patient with hypothroidism than that of euthyroid (p value<0.0001).Compared to euthyroid diabetics, hypothyroid cases had lower values of insulin resistance markers like fasting insulin, HOMA-IR and HOMA-B. Hyperthyoid cases had higher values. Conclusion: Hyperthyroid diabetics have higher insulin resistance as fasting insulin, HOMA-IR, HOMA-B showed negative correlation with TSH. (p value<0.05).

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Diabetes and thyroid disorders

Cited by 52 publications

References 56 publications

Lipid profile alterations and fasting blood glucose levels in primary hypothyroidism

Lipid profile alterations and fasting blood glucose levels in primary hypothyroidism

Hypothyroid States Mitigate the Diabetes-Induced Reduction of Calbindin D-28k, Calretinin, and Parvalbumin Immunoreactivity in Type 2 Diabetic Rats

Prevalence of thyroid dysfunction in patients with Type 2 diabetes mellitus and its correlation with insulin resistance and serum markers for autoimmune thyroiditis

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