Diabetes and the Tortuosity of Vessels of the Bulbar Conjunctiva

Owen, Christopher G.; Newsom, Richard; Rudnicka, Alicja R.; Barman, Sarah; Woodward, E. Geoffrey; Ellis, Tim

doi:10.1016/j.ophtha.2008.02.009

Cited by 84 publications

(82 citation statements)

References 31 publications

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“…Extensive clinical studies have shown that artery tortuosity is associated with hypertension, aging, atherosclerosis and other pathological changes in the arteries [4,5,6,7,8,13,24,33,57]. It is often reported in elderly populations with severe tortuosity and angulation being associated with aging; it rarely occurs in children [4,58,59].…”

Section: Etiology: Association With Vessel Diseases and Clinical Consmentioning

confidence: 99%

“…While mild tortuosity is a common anomaly without clinical symptoms, severe tortuosity can lead to various serious symptoms. Clinical observations have linked tortuous arteries and veins to aging, atherosclerosis, hypertension, genetic defects and diabetes mellitus [4,5,6,7,8]. However, the mechanisms of tortuous vessel formation and development are poorly understood.…”

Section: Introductionmentioning

confidence: 99%

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Twisted Blood Vessels: Symptoms, Etiology and Biomechanical Mechanisms

Han¹

2012

J Vasc Res

379

355

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Tortuous arteries and veins are commonly observed in humans and animals. While mild tortuosity is asymptomatic, severe tortuosity can lead to ischemic attack in distal organs. Clinical observations have linked tortuous arteries and veins with aging, atherosclerosis, hypertension, genetic defects and diabetes mellitus. However, the mechanisms of their formation and development are poorly understood. This review summarizes the current clinical and biomechanical studies on the initiation, development and treatment of tortuous blood vessels. We submit a new hypothesis that mechanical instability and remodeling could be mechanisms for the initiation and development of these tortuous vessels.

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Section: Etiology: Association With Vessel Diseases and Clinical Consmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Twisted Blood Vessels: Symptoms, Etiology and Biomechanical Mechanisms

Han¹

2012

J Vasc Res

379

355

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“…The tortuosity measures include arc/chord ratio, curve energy [36] and level-wise-mean, which is a subdivided chord length method [22].…”

Section: B Vessel Analysismentioning

confidence: 99%

Automated quantification of retinal vessel morphometry in the UK biobank cohort

Welikala

Fraz

Habib

et al. 2017

2017 Seventh International Conference on Image Processing Theory, Tools and Applications (IPTA)

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Abstract-The morphometric characteristics of the retinal vascular network have been associated with risk markers of many systemic and vascular diseases. However, analysis of data from large population based studies is needed to help resolve uncertainties in these associations. QUARTZ (QUantitative Analysis of Retinal vessel Topology and siZe) is a fully automated retinal image analysis system that has been designed to process large numbers of retinal images and obtains quantitative measures of vessel morphology to be used in epidemiological studies. QUARTZ has been used to process retinal images from UK Biobank which is a large population-based cohort study. In this paper, we address issues of robustness with respect to processing large datasets and validate QUARTZ using a subset of 4,692 UK Biobank retinal images. Ground truth data produced by human observers for validation have been made available online. Following validation, 135,867 retinal images (68,549 participants) from the UK Biobank study were processed by QUARTZ. 71.53% of these images were classified as being of adequate quality, which equated to 80.90% participants with at least one image of adequate quality. The vessel morphometric data are currently being used in epidemiological studies. The intention of the UK Biobank Eye and Vision Consortium is to include these derived measures in the UK Biobank data archive.

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“…Numerous studies have reported correlations between several pathologies and the tortuosity of a wide range of anatomical structures such as retinal vessels (Heneghan et al, 2002;Cheung et al, 2011;Sasongko et al, 2011Sasongko et al, , 2015Longmuir et al, 2010;Muraoka et al, 2014;Maude et al, 2014), intracerebral vessels (Bullitt et al, 2005) and conjunctival blood vessels Owen et al (2008), but also the coronary (Eleid et al, 2014), iliac (Coulston et al, 2014), carotid (Bogunović et al, 2012) and aortic (Franken et al, 2015) arteries, the optic nerve (Ji et al, 2013) and corneal nerve fibres (Kallinikos et al, 2004;Hamrah et al, 2010;Kurbanyan et al, 2012;Hamrah et al, 2013;Edwards et al, 2014).…”

Section: Introductionmentioning

confidence: 99%