Diabetes and the Female Reproductive System

Nandi, Anindita; Poretsky, Leonid

doi:10.1016/j.ecl.2013.07.007

Cited by 41 publications

(29 citation statements)

References 172 publications

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“…5 Insulin receptors present on the ovary and insulin-like growth factors enhance LH-dependent ovarian androgen synthesis and remain sensitive despite the presence of generalised insulin resistance. 6 Thus, a complex mechanism may exist where hyperandrogenism leads to insulin resistance and hyperinsulinism which in turn may result in the elevated insulin stimulating androgen release. It is tempting to speculate that an oophorectomy could disrupt this circular relationship.…”

Section: Discussionmentioning

confidence: 99%

Paradoxical glycaemic response to surgical treatment of ovarian hyperthecosis in a patient with type 2 diabetes

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Paradoxical glycaemic response to surgical treatment of ovarian hyperthecosis in a patient with type 2 diabetes

et al. 2015

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“…It is well-known that diabetes impairs reproductive functions, not only because chronic hyperglycemia leads to glucotoxicity and micro/ macrovascular diseases, but also because insulin signaling itself is needed for a proper activity of reproductive organs [ 120 ]. On one hand, ovary function and estrous cycle in females, and on the other hand, testosterone synthesis and total number of Leydig cells in males are altered, and therefore fertility declines in diabetic animal models [ 121 , 122 ]. Diminished serum levels of follicle-stimulating (FSH) and luteinizing (LH) hormones, and consequently, impaired ovarian production of estrogen and progesterone, and testicular production of testosterone, are also detected [ 37 , 38 ].…”

Section: Efect Of Sodium Tungstate (Naw) In Experimental Animal Modelmentioning

confidence: 99%

Preclinical and Clinical Studies for Sodium Tungstate: Application in Humans

Bertinat

Nualart

et al. 2015

J Clin Cell Immunol

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Diabetes is a complex metabolic disorder triggered by the deficient secretion of insulin by the pancreatic β-cell or the resistance of peripheral tissues to the action of the hormone. Chronic hyperglycemia is the major consequence of this failure, and also the main cause of diabetic problems. Indeed, several clinical trials have agreed in that tight glycemic control is the best way to stop progression of the disease. Many anti-diabetic drugs for treatment of type 2 diabetes are commercially available, but no ideal normoglycemic agent has been developed yet. Moreover, weight gain is the most common side effect of many oral anti-diabetic agents and insulin, and increased weight has been shown to worsen glycemic control and increase the risk of diabetes progression. In this sense, the inorganic salt sodium tungstate (NaW) has been studied in different animal models of metabolic syndrome and diabetes, proving to have a potent effect on normalizing blood glucose levels and reducing body weight, without any hypoglycemic action. Although the liver has been studied as the main site of NaW action, positive effects have been also addressed in muscle, pancreas, brain, adipose tissue and intestine, explaining the effective anti-diabetic action of this salt. Here, we review NaW research to date in these different target organs. We believe that NaW deserves more attention, since all available anti-diabetic treatments remain suboptimal and new therapeutics are urgently needed.

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“…The previous study reported that under the normal insulin action, insulin binds to its own receptors in the ovary to mediate steroidogenesis and act as a co‐gonadotropin and may influence ovarian growth and cyst formation with other factors. Therefore, type 1 diabetes patients who do not produce enough insulin or have dysregulation of insulin pathway were shown to suffer many reproductive problems that lead to altered puberty, ovulation, and fertility . The incidence of gestational diabetes (GD), a condition in which a female with no diabetes develops high blood sugar levels during pregnancy, is increasing worldwide .…”

Section: Introductionmentioning

confidence: 99%

Exposure to cigarette smoke via respiratory system may induce abnormal alterations of reproductive organs in female diabetic rats

Kim

Hwang

et al. 2018

Environmental Toxicology

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Cigarette smoke (CS) has harmful effects on human fertility, reproduction, and development as well as on patients suffering from metabolic diseases such as diabetes than on healthy individuals.This study was conducted to investigate the relationship between CS exposure and histological alterations of reproductive organs in female diabetic rats. We evaluated the histology of uteruses and ovaries obtained from female rats exposed to smoke from standard cigarettes for 4 weeks (28 hours a week). After CS exposure, tissue slides were made from uterine and ovarian samples and examined after hematoxylin and eosin staining. Immunohistochemistry was used for detection of matrix metallopeptidase 9 (MMP9), C-X-C chemokine receptor type 4 (CXCR4), and estrogen receptor (ER)α in the uterus and ovary. MMP9 is an inflammatory biomarker that increases during progression to endometriosis. As a chemokine receptor, CXCR4 is involved in development of the inner wall of the uterus and cell adhesion. In the uterus, the occurrence of MMP9, CXCR4, and ERα and the number of endometrial glands were increased by CS exposure, while in the ovary, occurrence of MMP9, CXCR4, ERα, proliferating cell nuclear antigen and the number of corpus lutea or cyst follicles were increased by CS exposure. Collectively, this study indicates that CS induced abnormal development of the uterus and ovary under induced diabetes, leading to adverse effects on normal function of reproductive organs in female rats. Highlights• Cigarette smoke (CS) exposure adversely affected reproductive organs of diabetic female rats.• In the uterus, expression of matrix metallopeptidase 9 (MMP9), C-X-C chemokine receptor type 4 (CXCR4), estrogen receptor (ER)α, and the number of endometrial glands were increased by CS exposure,• In the ovary, the expression of MMP9, CXCR4, ERα, and proliferating cell nuclear antigen and the number of corpus lutea or cyst follicles were increased by CS exposure.• Exposure to CS via the respiratory system exerted a harmful impact on the uterus and ovary in female rats with diabetes.

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Diabetes and the Female Reproductive System

Cited by 41 publications

References 172 publications

Paradoxical glycaemic response to surgical treatment of ovarian hyperthecosis in a patient with type 2 diabetes

Paradoxical glycaemic response to surgical treatment of ovarian hyperthecosis in a patient with type 2 diabetes

Preclinical and Clinical Studies for Sodium Tungstate: Application in Humans

Exposure to cigarette smoke via respiratory system may induce abnormal alterations of reproductive organs in female diabetic rats

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