2020
DOI: 10.1111/1753-0407.13142
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Diabetes and stroke: An important complication

Abstract: Diabetes is associated with a plethora of metabolic changes which may underlie the propensity to development of stroke (Figure 1). 1 Insulin resistance has multiple drivers, is inextricably linked to type 2 diabetes, and is associated with coronary artery 2 and cerebrovascular 3 atherosclerosis. Insulin resistance is mediated by increased levels of bioactive lipids, including ceramides 4 and diacylglycerol, 5 playing a role in cell death in numerous tissues. 6 Hyperglycemia leads to formation of advanced glyca… Show more

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Cited by 19 publications
(11 citation statements)
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“…Type 2 diabetes is among the well-established yet modifiable risk factors of stroke [ 23 , 24 ]. Individuals with type 2 diabetes have a 1.5 to 3 times increased risk of stroke than those without diabetes [ 25 ].…”
Section: Introductionmentioning
confidence: 99%
“…Type 2 diabetes is among the well-established yet modifiable risk factors of stroke [ 23 , 24 ]. Individuals with type 2 diabetes have a 1.5 to 3 times increased risk of stroke than those without diabetes [ 25 ].…”
Section: Introductionmentioning
confidence: 99%
“…DM is easy to cause various complications, and stroke is a common complication of DM [ 4 ]. According to relevant studies, the relative risk of stroke patients with DM is 1.8-6.0, and the combined disability rate and mortality rate are higher [ 5 , 6 ]. Stroke complicated with DM is quite common in clinic, mostly developing in middle-aged and elderly people.…”
Section: Introductionmentioning
confidence: 99%
“…According to previous research and our professional knowledge [ 21 25 ], the factors selected as potentially predictive for frailty were a history of chronic disease (hypertension, dyslipidemia, cancer, heart disease, chronic lung disease, stroke, mental disease, arthritis or rheumatism, liver disease, kidney disease, digestive disease, or asthma), waist circumference, grip strength, self-perceived health status, ADL score, medication, vision, hearing, pain, and cognitive function.…”
Section: Methodsmentioning
confidence: 99%