Diabetes and risk of physical disability in adults: a systematic review and meta-analysis

Wong, Evelyn; Backholer, Kathryn; Gearon, Emma; Harding, Jessica L.; Freak‐Poli, Rosanne; Stevenson, Christopher; Peeters, Anna

doi:10.1016/s2213-8587(13)70046-9

Cited by 341 publications

(279 citation statements)

References 66 publications

(122 reference statements)

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“…With aging, sarcopenic obesity (sarcopenia and relative increase of visceral fat) and mitochondrial dysfunction are thought to cause the insulin resistance whereas gradual exhaustion of β-cell function is thought to cause decline of initial phase of insulin secretion [2,4,5]. DM has been associated with an increased risk of developing physical disability in older adults [5,6]. DM is considered an independent risk factor in older people for fall and developing hip fractures [7].…”

Section: Introductionmentioning

confidence: 99%

Frailty in elderly diabetes patients

Yanase

Yanagita

Muta³

et al. 2018

Endocr J

119

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Abstract. Frailty is a state of vulnerability and a consequence of cumulative decline in multiple physiological systems over a lifespan. The occurrence of frailty depends on deterioration in muscle and nerve function, declining cardiopulmonary reserve and loss of executive function. Diabetes mellitus (DM) often causes functional impairment in each of the above systems, thus leading to a loss of whole body homeostasis and deterioration in physical function. Inability of self-management in DM patients may also have considerable impact on the development of sarcopenia/frailty. Thus, there may be positive feedback between the progression of diabetic complications and frailty/sarcopenia. While various factors are involved in this process, insulin resistance or insulin depletion may be an important factor in the progression of frailty in diabetes patients since insulin is well known to be an anabolic hormone in muscle. Interestingly, in our study targeting elderly DM patients, low HbA1c was a significant and independent risk factor for frailty, as assessed using a broad sense frailty scale, the Clinical Frailty Scale (CSF), suggesting that reverse metabolism due to malnutrition in elderly type 2 DM patients might be involved. Therefore, an intervention that includes proper nutrition and exercise training may be essential for the prevention of frailty. The pathogenesis of frailty in DM patients is extensively discussed in this review.

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Section: Introductionmentioning

confidence: 99%

Frailty in elderly diabetes patients

Yanase

Yanagita

Muta³

et al. 2018

Endocr J

119

View full text Add to dashboard Cite

show abstract

“…Diabetic older adults are at increased risk of cardiovascular disease and cancer, as well as cognitive dysfunction (3), functional limitations and disability (4,5). Frailty, a geriatric syndrome characterized by declines in functioning across multiple systems, is also an important predictor of disability (6).…”

Section: Introductionmentioning

confidence: 99%

Diabetes and Risk of Frailty and Its Potential Mechanisms: A Prospective Cohort Study of Older Adults

García‐Esquinas

Graciani

Guallar‐Castillón

et al. 2015

Journal of the American Medical Directors Association

127

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“…In addition to body structure and function impairments, adults with DM also have an increased risk for activity and participation limitations in the areas of mobility, activities of daily living (ADLs), and instrumental activities of daily living (IADLs) [3][4][5]. Egede [6] examined the prevalence of specific activity limitations in individuals with DM and found the following: 44% had difficulty stooping, bending or kneeling; 40% had difficulty standing on their feet for two hours; 39% had difficulty walking 12 city blocks, 32.2% had difficulty pushing or pulling heavy objects; 30.7% had difficulty climbing 10 steps; 25.4% had difficulty lifting ten pounds; 20.5% had difficulty shopping; 18.9% had difficulty grasping small objects; and 17% had difficulty both sitting for two hours and reaching overhead.…”

Section: Introductionmentioning

confidence: 99%

Validity of the Community Integration Questionnaire as a Measure of Participation in Persons with Diabetes Mellitus

Lp¹,

Mh²

2016

J Diabetes Metab

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Objective: The purpose of this study was to examine the validity of using the Community Integration Questionnaire (CIQ) with people with Diabetes Mellitus (DM). The CIQ measures levels of participation and frequency of engagement in activities.Methods: A convenience sample of 97 women participated in the study in three groups (DM=32; Rheumatoid Arthritis (RA)=29; Healthy Controls=36). Participants completed a demographic questionnaire, Keitel Functional Test, the Health Assessment Questionnaire (HAQ), the Dartmouth Primary Care Cooperative Information Project (COOP), and the CIQ. Results:The groups were similar in age, disease duration, education, and marital status. The DM group had significantly better joint motion compared to the RA group. For all CIQ domains and the CIQ Total, the scores of the DM group were each significantly higher than the RA group and similar to the HC group. A similar trend was found for the other measures of participation, the HAQ and COOP Total. In the DM group, the correlations between the CIQ Social, CIQ Productivity, CIQ Total and the HAQ and COOP were moderate to good. There were no significant correlations between the CIQ Home and the HAQ and COOP Total. Conclusion:The findings provide partial support for known-groups validity of the CIQ as there were significant differences in CIQ scores between individuals with DM and RA, two very different chronic diseases. However, there were no differences between the DM and HC groups. Concurrent validity in people with DM was established by the correlations between the CIQ Social, CIQ Productivity, and CIQ Total and the HAQ and COOP with people with DM. However, larger studies are needed to support these findings.

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Diabetes and risk of physical disability in adults: a systematic review and meta-analysis

Abstract: Monash University, Baker IDI Bright Sparks Foundation, Australian Postgraduate Award, VicHealth, National Health and Medical Research Council, Australian Research Council, Victorian Government.

Cited by 341 publications

References 66 publications

Frailty in elderly diabetes patients

Frailty in elderly diabetes patients

Diabetes and Risk of Frailty and Its Potential Mechanisms: A Prospective Cohort Study of Older Adults

Validity of the Community Integration Questionnaire as a Measure of Participation in Persons with Diabetes Mellitus

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