Diabetes and risk of incident cancer: a large population-based cohort study in Israel

Chodick, Gabriel; Heymann, Anthony; Rosenmann, Lena; Green, Manfred S.; Flash, Shira; Porath, Avi; Kokia, Ehud; Shalev, Varda

doi:10.1007/s10552-010-9515-8

Cited by 112 publications

(127 citation statements)

References 62 publications

(67 reference statements)

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“…There was also no significant difference overall in cancer deaths between the groups assigned to more intensive vs less intensive glucose lowering. The overall cancer event rate observed in our study of patients with long standing type 2 diabetes (1.33 per 100 PY) was similar to that of one large population-based study of people with diabetes (1.31 per 100 PY) [23] and [24]. Notably, both these cohort studies also examined cancer incidence in individuals free of diabetes and reported lower overall event rates (1.19 and 0.77 per 100 PY, respectively).…”

Section: Discussionsupporting

confidence: 87%

Intensive glucose control and risk of cancer in patients with type 2 diabetes

et al. 2011

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Section: Discussionsupporting

confidence: 87%

Intensive glucose control and risk of cancer in patients with type 2 diabetes

et al. 2011

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“…Reduced risk was found for skin cancer (0.38, 95% CI 0.22-0.66). Among men, there was no overall increase in cancer risk observed, but a decrease of 47% in the risk of prostate cancer was found (Chodick et al 2010).…”

Section: Relationship Of Diabetes and Cancer In Epidemiological Studiesmentioning

confidence: 85%

Glucose Metabolism Disorders and the Risk of Cancer

Piątkiewicz

Czech

2011

Arch. Immunol. Ther. Exp.

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Diabetes and cancer are diseases which take the size of an epidemic spread across the globe. Those diseases are influenced by many factors, both genetic and environmental. Precise knowledge of the complex relationships and interactions between these two conditions is of great importance for their prevention and treatment. Many epidemiological studies have shown that certain types of cancer, especially gastrointestinal cancers (pancreas, liver, colon) and also the urinary and reproductive system cancers in women are more common in patients with diabetes or related metabolic disorders. There are also studies showing the inverse relationship between diabetes and cancer, or the lack of it, but they are less numerous and relate mainly to prostate cancer or squamous cell carcinoma of the esophagus. Epidemiological studies, however, do not say anything about the mechanisms of these dependencies. For this purpose, molecular research is needed on the metabolism of cells (including tumor cells) and on metabolic dysfunctions that arise due to changes in the cell environment taking place in the sick, as well as in the intensely treated human organism.

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“…Fourteen studies reported a statistically significant increase in BC incidence in patients with diabetes mellitus (Goodman et al 1997, Sinagra et al 2002, Michels et al 2003 Troisi et al 1998, Weiss et al 1999, Baron et al 2001, Mink et al 2002, Lawlor et al 2004, Khan et al 2006, Garmendia et al 2007, Sellers et al 2007, Perrin et al 2008, Sanderson et al 2010, Lambe et al 2011, Carstensen et al 2012, Cleveland et al 2012, Yu et al 2012 while six studies favoured a decreased risk (Moseson et al 1993, Inoue et al 2006, Rollison et al 2008, La Vecchia et al 1994, Sella et al 2011, Chlebowski et al 2012. Three studies found no association between the two (Franceschi et al 1990, Chodick et al 2010, Bowker et al 2011. Quantitative analysis revealed a significant pooled risk point estimate of 1.20 (95% CI 1.13-1.29) (Fig.…”

Section: Non-specific Diabetes Mellitusmentioning

confidence: 98%

Diabetes increases the risk of breast cancer: a meta-analysis

Hardefeldt

Edirimanne

Eslick

2012

Endocrine-Related Cancer

132

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The aim of this meta-analysis was to collate and analyse all primary observational studies investigating the risk of breast cancer (BC) associated with diabetes. In addition, we aimed to complete subgroup analyses by both type of diabetes and gender of study participants to further clarify the origin of any such association between the two. Studies were obtained from a database search of MEDLINE, EMBASE, PubMed, Current Contents Connect and Google Scholar with additional cross-checking of reference lists. Collated data were assessed for heterogeneity and a pooled odds ratio (OR) calculated. Forty-three studies were included in the meta-analysis with 40 studies investigating BC in women and six studies investigating BC in men. Overall, we found a significantly increased risk of BC associated with diabetes in women (OR 1.20, 95% confidence interval (CI) 1.13-1.29). After subgroup analysis by type of diabetes, the association was unchanged with type 2 diabetes (OR 1.22, 95% CI 1.07-1.40) and nullified with gestational diabetes (OR 1.06, 95% CI 0.79-1.40). There were insufficient studies to calculate a pooled OR of the risk of BC associated with type 1 diabetes. There was an increased risk of BC in males with diabetes mellitus; however, the results did not reach statistical significance (OR 1.29, 95% CI 0.99-1.67). In conclusion, diabetes increases the risk of BC in women. This association is confirmed in women with type 2 diabetes and supports the hypothesis that diabetes is an independent risk factor for BC.

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Diabetes and risk of incident cancer: a large population-based cohort study in Israel

Cited by 112 publications

References 62 publications

Intensive glucose control and risk of cancer in patients with type 2 diabetes

Intensive glucose control and risk of cancer in patients with type 2 diabetes

Glucose Metabolism Disorders and the Risk of Cancer

Diabetes increases the risk of breast cancer: a meta-analysis

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