Diabetes and premature menopause: is their co-existence detrimental to the skeleton?

Hadjidakis, D.; Mylonakis, A.; Sfakianakis, Michael; Raptis, Athanasios; Raptis, Sotirios A.

doi:10.1530/eje.1.01853

Cited by 13 publications

(6 citation statements)

References 24 publications

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“…Moreover, point biserial correlation and Ferguson's sigma values which are an item-total correlation and discriminatory power, respectively, were within the acceptable range and indicated that the tool is reliable and discriminating [23,32]. *Sum of the potential range for the Exercise subscale and Calcium intake subscale was larger than total potential range because the two subscales shared nine common questions (1)(2)(3)(4)(5)(6)(7)(8)(9). The results showed low correct answer frequencies for all dimension with low overall knowledge score.…”

Section: Discussionmentioning

confidence: 99%

Cross-Cultural Adaptation and Psychometric Properties of Osteoporosis Knowledge Tool-Arabic Version Among Iraqi Population

Abdulameer¹,

Sahib²

2019

TORJ

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Background:Osteoporosis is a major public health problem as the majority of people are not aware of the disease until the complications occur.Objective:The aims of this study were to validate Osteoporosis Knowledge Tool (OKT-A) Arabic version and to assess the osteoporosis knowledge among Iraqi general population.Methods:A descriptive, cross-sectional study was carried out in the city of Baghdad with a random cluster sampling method from the community. Forward–backward-forward translation method was used to translate the OKT questionnaire from English into Arabic language. The psychometric assessment process includes: face validity, reliability (Cronbach’s alpha and test-retest), item difficulty index, point biserial correlation and discriminatory power.Results:The results showed good face validity. The Cronbach’s alpha and Pearson correlation coefficient of the test re-test reliability were 0.775 and 0.412, respectively. Item difficulty index, point biserial correlation ranges and discriminatory power were 0.105 to 0.852, 0.105 to 0.445 and 0.933, respectively. These results demonstrated that OKT-A was a reliable and stable tool. The results showed low OKT-A scores 11.50±3.958. Furthermore, the OKT-A scores and its subscales were less than 50%. In addition, there were significant differences between the following independent variables in relation to total OKT-A scores: educational level, do you have osteoporosis or ever heard about osteoporosis. Moreover, there was a significant association between ever heard about osteoporosis groups and the OKT-A knowledge levels.Conclusion:This study showed good validity and reliability of OKT-A tool among Arabic general population. In addition, the results showed an urgent need for implementing an educational programme and should be a public health practice to increase the knowledge toward osteoporosis and its related risk factor.

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Section: Discussionmentioning

confidence: 99%

Cross-Cultural Adaptation and Psychometric Properties of Osteoporosis Knowledge Tool-Arabic Version Among Iraqi Population

Abdulameer¹,

Sahib²

2019

TORJ

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“…Diabetes mellitus is a chronic metabolic disorder with substantial morbidity and mortality, and osteoporosis is a silent disease, also with harmful impact on morbidity and mortality [1, 20]. Osteoporosis leads to increase in skeletal fragility and microarchitecture deterioration of bone tissue with a decrease in bone mineral density (BMD), bone quality, and strength [9, 62].…”

Section: Other Diabetic Complicationsmentioning

confidence: 99%

Diabetic Complications in Obese Type 2 Diabetic Rat Models

et al. 2014

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We overviewed the pathophysiological features of diabetes and its complications in obese type 2 diabetic rat models: Otsuka Long-Evans Tokushima fatty (OLETF) rat, Wistar fatty rat, Zucker diabetic fatty (ZDF) rat and Spontaneously diabetic Torii (SDT) fatty rat. Pancreatic changes with progression of diabetes were classified into early changes, such as islet hypertrophy and degranulation of β cells, and degenerative changes, such as islet atrophy and fibrosis of islet with infiltration of inflammatory cells. Renal lesions in tubuli and glomeruli were observed, and nodular lesions in glomeruli were notable changes in OLETF and SDT fatty rats. Among retinal changes, folding and thickening were interesting findings in SDT fatty rats. A decrease of motor nerve conduction velocity with progression of diabetes was presented in obese diabetic rats. Other diabetic complications, osteoporosis and sexual dysfunction, were also observed. Observation of bone metabolic abnormalities, including decrease of osteogenesis and bone mineral density, and sexual dysfunction, including hypotestosteronemia and erectile dysfunction, in obese type 2 diabetic rats have been reported.

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“…Pharmacotherapy, continuing medical care, and education are crucial for preventing acute and chronic complications. On the other hand, osteoporosis (OP) is a painless weakening of the bones that constitutes an enormous socioeconomic crisis, with a harmful impact on morbidity and mortality 3,4. It leads to increased skeletal fragility and microarchitectural deterioration of bone tissue, causing a decrease in bone mineral density (BMD), bone quality, and strength 5,6.…”

Section: Introductionmentioning

confidence: 99%

Osteoporosis and type 2 diabetes mellitus: what do we know, and what we can do?

Abdulameer¹,

Sulaiman²,

Hassali³

et al. 2012

PPA

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Diabetes mellitus (DM) is a pandemic and chronic metabolic disorder with substantial morbidity and mortality. In addition, osteoporosis (OP) is a silent disease with a harmful impact on morbidity and mortality. Therefore, this systematic review focuses on the relationship between OP and type 2 diabetes mellitus (T2DM). Systematic reviews of full-length articles published in English from January 1950 to October 2010 were identified in PubMed and other available electronic databases on the Universiti Sains Malaysia Library Database. The following keywords were used for the search: T2DM, OP, bone mass, skeletal. Studies of more than 50 patients with T2DM were included. Forty-seven studies were identified. The majority of articles (26) showed increased bone mineral density (BMD), while 13 articles revealed decreased BMD; moreover, eight articles revealed normal or no difference in bone mass. There were conflicting results concerning the influence of T2DM on BMD in association with gender, glycemic control, and body mass index. However, patients with T2DM display an increased fracture risk despite a higher BMD, which is mainly attributable to the increased risk of falling. As a conclusion, screening, identification, and prevention of potential risk factors for OP in T2DM patients are crucial and important in terms of preserving a good quality of life in diabetic patients and decreasing the risk of fracture. Patients with T2DM may additionally benefit from early visual assessment, regular exercise to improve muscle strength and balance, and specific measures for preventing falls. Patient education about an adequate calcium and vitamin D intake and regular exercise is important for improving muscle strength and balance. Furthermore, adequate glycemic control and the prevention of diabetic complications are the starting point of therapy in diabetic patients.

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Diabetes and premature menopause: is their co-existence detrimental to the skeleton?

Cited by 13 publications

References 24 publications

Cross-Cultural Adaptation and Psychometric Properties of Osteoporosis Knowledge Tool-Arabic Version Among Iraqi Population

Cross-Cultural Adaptation and Psychometric Properties of Osteoporosis Knowledge Tool-Arabic Version Among Iraqi Population

Diabetic Complications in Obese Type 2 Diabetic Rat Models

Osteoporosis and type 2 diabetes mellitus: what do we know, and what we can do?

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