Diabetes and Month of Birth

Christy, M.; Christau, Bjo̸rn; Mølbak, Anne Grethe; Nerup, Jørn

doi:10.1016/s0140-6736(82)91061-3

Cited by 7 publications

(2 citation statements)

References 3 publications

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“…It should be noted that seasonality of births has been described in some other disorders—for example, diabetes mellitus (Christy et al 1982). An excess of winter births has been reported for certain congenital anomalies and diseases, such as anencephaly, malformations of the cardiovascular system, congenital hip dislocation, and Down’s syndrome (Jongbloet, Mulder, and Hamers 1982).…”

Section: Unusual Epidemiological Findings: Seasonality Of Birthsmentioning

confidence: 99%

Epidemiology of Schizophrenia: A European Perspective

Jablensky

1986

Schizophrenia Bulletin

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Since its inception, the concept of dementia praecox and, later, of schizophrenia has been one of the most disputed entities in modern medicine. Schizophrenia was, and still is, defined by its clinical symptoms and their characteristic evolution over time. No external validating criteria for the diagnosis have been established, in spite of a host of suggestive biological findings, among which the genetic data carry most weight. This absence of clear-cut substrate markers and indicators underscores the importance of the epidemiological perspective in the study of the disorder. The European contributions to the epidemiological description and understanding of schizophrenic morbidity are numerous. They range from community surveys and studies of pedigrees to case-control designs for assessment of risk factors and long-term followup investigations of course and outcome. This review focuses on epidemiological approaches to schizophrenia that have attempted to highlight the essential attributes of a disease: its incidence and prevalence, ecology, and associated features. It is difficult to generalize about European epidemiological research in schizophrenia, because of the coexistence of a variety of "schools," traditions, and approaches. It is nevertheless possible to discern several clear trends in European epidemiological investigations of schizophrenia that can, to some extent, be contrasted to North American developments.

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Section: Unusual Epidemiological Findings: Seasonality Of Birthsmentioning

confidence: 99%

Epidemiology of Schizophrenia: A European Perspective

Jablensky

1986

Schizophrenia Bulletin

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“…Investigations by Helgason and Jonasson (1981) and Helgason et aL (1982) showed that nitroso compounds from food contribute to the production of type I diabetes not in the consumer, but in the progeny of human beings and mice. However, the absence of correlation between month of birth and diabetes onset noted in other Scandinavian countries (Christy et al, 1982) does not support this view.…”

Section: Resultsmentioning

confidence: 75%

Diabetogenic Effects of N-Nitrosomethylurea in Rats

Voss¹,

Herrmann²,

Hartmann³

et al. 2009

Exp Clin Endocrinol Diabetes

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The influence of a single i.v. injection of 75 or 175 mg N-nitrosomethylurea (NMU)/kg into Wistar rats on plasma glucose, i.p. glucose tolerance, plasma insulin and glucagon, glucose stimulated insulin secretion and release as well as on the biosynthesis of insulin in isolated pancreatic islets have been investigated at set intervals between the 3rd day and the 6th week post injectionem. At the end of the experimental period all NMU-treated animals were alive but had significantly reduced body mass. All animals remained normoglycemic even after the glucose load. 3 days after drug application plasma insulin decreased only insignificantly in the 175 mg NMU-group, whereas plasma glucagon was significantly reduced in both drug-groups; after 3 and 6 weeks the reduction of plasma glucagon was still about 30 percent. In isolated islets the glucose stimulated insulin secretion, the percent stimulation of insulin release and insulin biosynthesis were significantly decreased.

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The Autoimmune Hypothesis of Insulin-Dependent Diabetes: 1965 to the Present

Mandrup‐Poulsen¹,

Nerup²

1990

Autoimmunity and the Pathogenesis of Diabetes

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Diabetes and Month of Birth

Cited by 7 publications

References 3 publications

Epidemiology of Schizophrenia: A European Perspective

Epidemiology of Schizophrenia: A European Perspective

Diabetogenic Effects of N-Nitrosomethylurea in Rats

The Autoimmune Hypothesis of Insulin-Dependent Diabetes: 1965 to the Present

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