Diabetes and hypertriglyceridemia modify the mode of acetaminophen-induced hepatotoxicity and nephrotoxicity in rats and mice

Doi, Kunio; Ishida, Katsuhiko

doi:10.2131/jts.34.1

Cited by 14 publications

(2 citation statements)

References 119 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Yet, sustained NAPQI formation eventually causes depletion of glutathione, which then in turn leads to formation of protein adducts as well as reactive nitrogen and oxygen species (Figure 1). Very likely mitochondrial dysfunction and increased permeability of the mitochondrial membranes contribute to the formation of reactive nitrogen and oxygen metabolites such as peroxynitrate and hydrogen peroxide besides others, which in turn mediate protein nitration and oxidative stress (Jaeschke et al, 2002; James et al, 2003; Jaeschke and Bajt, 2006; Doi and Ishida, 2009). Obviously, besides the hepatocytes non-parenchymal cells such as Kupffer cells and sinusoidal endothelial cells seem to be involved in the generation of reactive nitrogen and oxygen species thus augmenting protein and lipid peroxidation.…”

Section: Molecular Principles Of Tissue Toxicity In Alf Induced By Pamentioning

confidence: 99%

Rodent Animal Models for Surrogate Analysis of Cell Therapy in Acute Liver Failure

Christ¹,

Brückner²

2012

Front. Physio.

View full text Add to dashboard Cite

Without therapeutic intervention acute liver failure (ALF) is the consequence of a progredient destruction of the liver parenchyma due to metabolic exhaustion of the hepatocytes. Perivenous hepatocytes are responsible for the detoxification of noxious compounds via the cytochrome P450 enzyme system. Liver transplantation is the only remaining therapeutic option in the end-stage of the disease. Assuming that metabolic capacity could be provided by healthy hepatocytes and thus substitute for the genuine parenchymal cells hepatocyte transplantation since quite some time is considered to be an alternative to whole liver transplantation. While this hypothesis achieved proof-of-concept in animal trials clinical breakthrough is still awaiting success, the reasons of which are ongoing matter of debate. In recent times mesenchymal stem cells (MSC) came into focus as a transplantable cell source to treat ALF. Interestingly, as demonstrated in various rodent animal models their mode of action is rather based on trophic support of hepatocytes remaining in the damaged host parenchyma rather than substitution of tissue loss. Mechanistically, either direct or indirect paracrine effects from the transplanted cells acting pro-proliferative, anti-apoptotic, and anti-inflammatory seem to trigger the regenerative response of the residual healthy hepatocytes in the otherwise lethally injured liver parenchyma. Thus, allogeneic MSC may be the best choice for the treatment of ALF taking advantage of their short-term benefit to sustain the critical phase of the acute insult avoiding long-term immunosuppression.

show abstract

Section: Molecular Principles Of Tissue Toxicity In Alf Induced By Pamentioning

confidence: 99%

Rodent Animal Models for Surrogate Analysis of Cell Therapy in Acute Liver Failure

Christ¹,

Brückner²

2012

Front. Physio.

View full text Add to dashboard Cite

show abstract

“…Although an APAP overdose can induce fatal liver and renal damage, its adverse effects, including gastrointestinal disease, are considered less severe than those associated with the NSAIDs (Barrett, 1996;Doi and Ishida, 2009;Ghosh and Sil, 2007;James et al, 2003;Mazer and Perrone, 2008;Trumper et al, 1996). Alternatively, APAP has traditionally not been classified as an NSAID because of its weak anti-inflammatory activity.…”

Section: Introductionmentioning

confidence: 99%

Effect of acetaminophen on the progression of renal damage in adenine induced renal failure model rats

et al. 2012

View full text Add to dashboard Cite

Harnessing the power of Arctium lappa root: a review of its pharmacological properties and therapeutic applications

Shyam,

Sabina

2024

Nat. Prod. Bioprospect.

View full text Add to dashboard Cite

Arctium lappa, widely recognized as burdock, is a perennial plant that is employed in the realm of traditional Chinese medicine for a wide range of medicinal applications. The herb is rich in bioactive metabolites with therapeutic potential, encompassing polyphenolic antioxidants in its leaves, and flavonoids and fructo-oligosaccharides in its underground parts. Nutraceuticals originating from botanical sources such as Arctium lappa provide supplementary health advantages alongside their nutritional content and have demonstrated effectiveness in the prevention and management of specific ailments. The utilization of Arctium lappa root extract has exhibited encouraging outcomes in addressing hepatotoxicity induced by cadmium, lead, chromium, and acetaminophen, ameliorating liver damage and oxidative stress. Additionally, the root extract displays properties such as antidiabetic, hypolipidemic, aphrodisiac, anti-rheumatic, anti-Alzheimer, and various other pharmacological actions. Graphical abstract

show abstract

Diabetes and hypertriglyceridemia modify the mode of acetaminophen-induced hepatotoxicity and nephrotoxicity in rats and mice

Cited by 14 publications

References 119 publications

Rodent Animal Models for Surrogate Analysis of Cell Therapy in Acute Liver Failure

Rodent Animal Models for Surrogate Analysis of Cell Therapy in Acute Liver Failure

Effect of acetaminophen on the progression of renal damage in adenine induced renal failure model rats

Harnessing the power of Arctium lappa root: a review of its pharmacological properties and therapeutic applications

Contact Info

Product

Resources

About