Diabetes and Hypertension

Teuscher, A; Egger, Matthias; Herman, Joseph

doi:10.1001/archinte.1989.00390090024005

Cited by 55 publications

(3 citation statements)

References 16 publications

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“…Long-term systemic complications of diabetes mellitus may include diabetic retinopathy, potentially leading to loss of vision, atherosclerotic cerebrovascular, cardiovascular and peripheral vascular diseases, peripheral neuropathy, which may lead to loss of limbs and dyesthesias (burning), progressive renal dysfunction, delayed wound healing and increased susceptibility to periodontal disease (47,53,60,61,97).…”

mentioning

confidence: 99%

Periodontal management of the patient with diabetes mellitus

Rees¹

2000

Periodontology 2000

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Diabetes mellitus is a common medical disorder that will be encountered by every practicing dentist. Knowledge by the dentist of the general and oral signs and symptoms of undiagnosed or poorly controlled diabetes mellitus are essential, and patients displaying these signs or symptoms should receive medical referral. Patients suspected, or known to suffer from undiagnosed or uncontrolled diabetes mellitus should receive only emergency care until their health status has been properly evaluated. In the event the degree of control of a known diabetic is unknown or the patient is poorly controlled, antibiotic therapy should be administered in conjunction with any necessary surgical procedure or in the presence of oral infection. The practitioner must be prepared to manage diabetic emergencies should they occur in the dental office, and hypoglycemic incidents are most likely. The developing therapies now available for medical management of diabetes mellitus suggest that this condition will be more effectively controlled in the future, but medical consultation is important to proper periodontal patient management. New evidence suggests that advanced periodontal disease may interfere with diabetes mellitus control and the physician should be made aware of the patient's periodontal status. Under most circumstances, the well-controlled diabetes mellitus patient can receive safe and effective periodontal therapy with some modification of office protocol, and there is little reason to anticipate that the controlled diabetes mellitus patient cannot look forward to a lifetime of periodontal health if proper and timely periodontal therapy is rendered and the patient maintains effective oral hygiene measures accompanied by appropriate supportive periodontal recall therapy.

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mentioning

confidence: 99%

Periodontal management of the patient with diabetes mellitus

Rees¹

2000

Periodontology 2000

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“…Diabetes and hypertension are interrelated and frequently coexist (91). The prevalence of hypertension in diabetic subjects is approximately twice that of the nondiabetic population (25,51,72,93,95…”

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confidence: 99%

Enhanced hemodynamic responses to angiotensin II in diabetes are associated with increased expression and activity of AT1 receptors in the afferent arteriole

Zhang

Song

et al. 2017

Physiological Genomics

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The prevalence of hypertension is about twofold higher in diabetic than in nondiabetic subjects. Hypertension aggravates the progression of diabetic complications, especially diabetic nephropathy. However, the mechanisms for the development of hypertension in diabetes have not been elucidated. We hypothesized that enhanced constrictive responsiveness of renal afferent arterioles (Af-Art) to angiotensin II (ANG II) mediated by ANG II type 1 (AT1) receptors contributes to the development of hypertension in diabetes. In response to an acute bolus intravenous injection of ANG II, alloxan-induced diabetic mice exhibited a higher mean arterial pressure (MAP) (119.1 ± 3.8 vs. 106.2 ± 3.5 mmHg) and a lower renal blood flow (0.25 ± 0.07 vs. 0.52 ± 0.14 ml/min) compared with nondiabetic mice. In response to chronic ANG II infusion, the MAP measured with telemetry increased by 55.8 ± 6.5 mmHg in diabetic mice, but only by 32.3 ± 3.8 mmHg in nondiabetic mice. The mRNA level of AT1 receptor increased by ~10-fold in isolated Af-Art of diabetic mice compared with nondiabetic mice, whereas ANG II type 2 (AT2) receptor expression did not change. The ANG II dose-response curve of the Af-Art was significantly enhanced in diabetic mice. Moreover, the AT1 receptor antagonist, losartan, blocked the ANG II-induced vasoconstriction in both diabetic mice and nondiabetic mice. In conclusion, we found enhanced expression of the AT1 receptor and exaggerated response to ANG II of the Af-Art in diabetes, which may contribute to the increased prevalence of hypertension in diabetes.

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“…По одним данным [2,6], для больных диабетом характерен гиперкинетический тип центральной гемодинамики, по другим [7,10] гипокинетический. Отмечая связь диабета с ар териальной гипертензией [17,22], некоторые авто ры [20] указывают на зависимость уровня систо лического артериального давления от продолжи тельности диабета.…”

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Myocardial involvement in diabetes mellitus: echocardiography data

Sokolov¹,

Zayev²,

Ol'kha³

et al. 1996

Probl Endokrinol (Mosk)

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Echocardiographic parameters of the central and intracardiac hemodynamics were analyzed in 67 patients with compensated diabetes mellitus of types I and II of 2 to 6 years standing. The control group consisted of 30 subjects. The increase of the minute volume, stroke volume, specific power of the left ventricle, and reduction of total peripheral resistance were revealed in both groups of patients. These shifts are characteristic of a hyperkinetic type of central hemodynamics. The hyperdynamic syndrome was due to left-ventricular hypertrophy in patients with noninsulin-dependent diabetes and due to increased heart rate and the rate of circulatory shortening of myocardial fibers in patients with the insulin-dependent condition. Impaired diastolic function presenting as an increase of the end diastolic volume and a reduced rate of relaxation of the left-ventricular posterior wall myocardium were observed in all the patients, no matter what the type of the condition. The above shifts are predictors of a reduction of myocardial contractility, responsible for the grave and atypical course of coronary disease in diabetics.

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Diabetes and Hypertension

Cited by 55 publications

References 16 publications

Periodontal management of the patient with diabetes mellitus

Periodontal management of the patient with diabetes mellitus

Enhanced hemodynamic responses to angiotensin II in diabetes are associated with increased expression and activity of AT1 receptors in the afferent arteriole

Myocardial involvement in diabetes mellitus: echocardiography data

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