Diabetes and haemodynamic reactions to acute coronary occlusion

Insulin status differentially affects energy transduction in cardiac mitochondria from male and female rats

“…Taken together, these observations also suggest that insulin status may also influence the rate of electron transport independent of primary dehydrogenase activities and cytochrome contents. The overall results are consistent with the notion that all the maladies of membrane dysfunction in [12][13][14]29].…”

“…Taken together, these observations also suggest that insulin status may also influence the rate of electron transport independent of primary dehydrogenase activities and cytochrome contents. The overall results are consistent with the notion that all the maladies of membrane dysfunction in diabetes are not corrected by insulin treatment [12–14,29]. Recently, it has been reported that the pathies associated with diabetes were corrected by giving supra‐physiological doses of C‐peptide [30,31].…”

“…Uusitupa has also reported similar findings [11]. It has also been reported that insulin treatment for 1 year did not reverse the myocardial abnormalities [12–14]. Similar findings have been reported recently in Australian aboriginal population [9].…”

“…In view of this, it was of interest to find out if the differential susceptibility of diabetic females to CHD and CHF [1][2][3][4][5][6][7][8][9] was related to basic differences in mitochondrial energy metabolism in the male and female cardiac tissues. Because it has been reported that the incidence of CHD and CHF remained higher in insulin-treated diabetics [12][13][14], it was also of interest to evaluate the comparative role of insulin treatment in males and females.…”

Sudden cardiac death: influence of diabetes

“…The same conclusion can be drawn from data of the recent Arrhythmia Genetics in the Netherlands Trial, which analysed predisposing risks for VF in revascularized cardiac patients [31]. A final, relatively unique piece of information on the issue of acute susceptibility comes from the finding that incidence of experimentally induced ventricular arrhythmias in diabetic vs. non‐diabetic cardiac patients was not different following intentional total coronary artery balloon occlusion [57].…”