Diabetes and covid-19: a global health challenge

Shenoy, Akhil; Ismaily, Mehwish; Bajaj, Mandeep S

doi:10.1136/bmjdrc-2020-001450

Cited by 45 publications

(34 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, the presence of diabetes in COVID-19 patients has been consistently reported to increase disease severity and the mortality risk [25,26]. A recent Chinese study reported that diabetes was an associated comorbidity in 14% of patients that survived COVID-19, but in 31% of those that did not survive [25], and Shenoy et al, reported that the prevalence of diabetes was almost three times higher in COVID-19 patients with severe disease (16.2%) than in those with non-severe disease (5.7%) [26]. These findings suggest COVID-19 patients with diabetes should be prioritized and that focused preventive strategies be instituted to address diabetes and other associated comorbid conditions in order to reduce growing COVID-19 mortality and other poor health outcomes.…”

Section: Discussionmentioning

confidence: 99%

Mortality Rate and Predictors of Mortality in Hospitalized COVID-19 Patients with Diabetes

Acharya

Lee

et al. 2020

Healthcare

View full text Add to dashboard Cite

Studies have confirmed COVID-19 patients with diabetes are at higher risk of mortality than their non-diabetic counterparts. However, data-driven evidence of factors associated with increased mortality risk among hospitalized COVID-19 patients with diabetes is scarce in South Korea. This study was conducted to determine the mortality rate and identify risk factors of mortality among hospitalized COVID-19 patients with type 2 diabetes in Gyeongsangbuk-do province, South Korea. In this hospital-based, cross-sectional study, we enrolled a total of 324 patients with confirmed COVID-19, hospitalized at two of the tertiary level healthcare facilitates of Gyeongsangbuk-do, South Korea from 18 February to 30 June 2020. Demographic and clinical data and laboratory profiles were analyzed and multivariate logistic regression analysis was used to identify risk factors of mortality among diabetic patients with COVID-19. Of the 324 patients, 55 (16.97%) had diabetes mellitus. The mean age of all study subjects was 55 years, and the mean age of those with diabetes was greater than that of those without (69.8 years vs. 51.9 years). Remarkably, the mortality rate was much higher among those with diabetes (20.0% vs. 4.8%). Multivariate logistic regression analysis revealed that an older age (≥70 years) and a high serum lactate dehydrogenase (LDH) levels significantly predicted mortality among hospitalized COVID-19 patients with diabetes. Our study cautions more attention to be paid to patients with diabetes mellitus hospitalized for COVID-19, especially those aged ≥ 70 years and those with a high serum LDH level, to reduce the risk of mortality.

show abstract

Section: Discussionmentioning

confidence: 99%

Mortality Rate and Predictors of Mortality in Hospitalized COVID-19 Patients with Diabetes

Acharya

Lee

et al. 2020

Healthcare

View full text Add to dashboard Cite

show abstract

“…Preexisting conditions such as diabetes mellitus, cardiovascular disease, hypertension and obesity also increase the risk of death [ 42 , 43 , 44 , 45 ]. Diabetes and cardiovascular disease are found disproportionately in severe cases of Covid-19 requiring ICU admission [ 46 , 47 , 48 , 49 ]. Obesity may compromise ventilation at the lung bases and can be considered a state of low grade inflammation and both these factors may contribute to risk of severe Covid-19 infection and greater need for mechanical ventilation in obese patients, especially in patients under age 65 [ 42 , 50 ].…”

Section: Covid-19 Risk Factorsmentioning

confidence: 99%

A Telemedicine Approach to Covid-19 Assessment and Triage

et al. 2020

View full text Add to dashboard Cite

Covid-19 is a new highly contagious RNA viral disease that has caused a global pandemic. Human-to-human transmission occurs primarily through oral and nasal droplets and possibly through the airborne route. The disease may be asymptomatic or the course may be mild with upper respiratory symptoms, moderate with non-life-threatening pneumonia, or severe with pneumonia and acute respiratory distress syndrome. The severe form is associated with significant morbidity and mortality. While patients who are unstable and in acute distress need immediate in-person attention, many patients can be evaluated at home by telemedicine or videoconferencing. The more benign manifestations of Covid-19 may be managed from home to maintain quarantine, thus avoiding spread to other patients and health care workers. This document provides an overview of the clinical presentation of Covid-19, emphasizing telemedicine strategies for assessment and triage of patients. Advantages of the virtual visit during this time of social distancing are highlighted.

show abstract

“…The prevalence of diabetes in patients with COVID-19 (Coronavirus Disease 2019), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has varied across countries, ranging from 5-20% in China, 17% in Lombardy in Italy and 33% in the US [1][2][3][4]. Diabetes can modulate host-viral interactions and host-immune responses via several mechanisms that could also lead to poorer outcomes (see Muniyappa and Gubbi for a review [5]).…”

Section: Introductionmentioning

confidence: 99%