Diabetes and Coronary Heart Disease: A Risk Factor for the Global Epidemic

Chiha, Maguy; Njeim, Mario; Chedrawy, Edgar G.

doi:10.1155/2012/697240

Cited by 84 publications

(72 citation statements)

References 63 publications

(62 reference statements)

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“…This includes a higher incidence of cardiovascular diseases and risk of cardiovascular death compared to the background population (Chiha, Njeim, & Chedrawy, 2012). One major cause of morbidity and mortality in persons with diabetes is diabetic nephropathy, which is the leading cause of chronic kidney disease (CKD) and end-stage renal disease worldwide (Pugliese, 2014).…”

Section: Introductionmentioning

confidence: 99%

Association between copeptin and declining glomerular filtration rate in people with newly diagnosed diabetes. The Skaraborg Diabetes Register

Pikkemaat

Melander

Boström

2015

Journal of Diabetes and its Complications

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Section: Introductionmentioning

confidence: 99%

Association between copeptin and declining glomerular filtration rate in people with newly diagnosed diabetes. The Skaraborg Diabetes Register

Pikkemaat

Melander

Boström

2015

Journal of Diabetes and its Complications

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“…Both uncontrolled hypertension and diabetes have strong influence on ACS. [19][20] Another notable fact is that the patients of upper and middle class have a strong tendency to go to specialized centers in Dhaka or Chittagong for better treatment of ACS.…”

Section: Discussionmentioning

confidence: 99%

Socio-economic Status of the Patients with Acute Coronary Syndrome: Data from a District-level General Hospital of Bangladesh

Ahmed¹,

Shiraji

Chowdhury³

et al. 2017

Cardiovasc. j.

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Background: Several studies have reported the correlation between socio-economic status (SES) and incidence of acute coronary syndrome (ACS). However, none of these studies have included data on Bangladesh. Hence, we aimed to find out the SES among the patients with ACS admitted in a district-level general hospital of Bangladesh.Methods: All the patients with a diagnosis of ACS admitted from March 2016 to February 2017 in the Cardiology department of 250-bedded General Hospital (Abdul Malek Ukil Medical College & Hospital), Noakhali were enrolled in this study. Data on demography, risk factors and SES parameters of the patients was screened and recorded with the help of a pre-defined questionnaire. Socioeconomic profile of the patients was defined according to modified Kuppuswamy SES scale.Results: A total of 366 patients were included (mean age 56.6 ± 11.5 years, 261 male and 105 female). Most of the patients had multiple risk factors like smoking, hypertension, diabetes, dyslipidemia and family history of cardiovascular disease. 80.1% (n=293) of the studied patients were from lower socio-economic class followed by 18.3% (n=67) from middle class and only 1.6% (n=6) were from upper class.Conclusion: This study found that most of the patients admitted due to ACS in a district-level general hospital of Bangladesh are from lower socio-economic class. These findings could be useful to draw the attention of health authorities towards people of lower socio-economic class and to adopt preventive strategies for them against ACS.Cardiovasc. j. 2017; 10(1): 17-20

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“…Diabetes and coronary artery disease are often present in the same patient [20]. Prior clinical studies have shown that diabetic patients have a higher mortality rate than nondiabetic patients after myocardial infarction [21,22].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Ivabradine on Cardiac Function after Myocardial Infarction are Weaker in Diabetic Rats

Cao¹,

Sun²,

Zhang³

et al. 2016

Cell Physiol Biochem

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Background/Aims: Plasma norepinephrine (NE) and brain natriuretic peptide (BNP, termed BNP-45 in rats) are considered as essential neurohormones indicating heart failure progression. The purposes of this study were to examine the effects of ivabradine (IBD) on cardiac function and plasma NE and BNP-45 after chronic ischemic heart failure (CHF) in non-diabetic rats and diabetic rats. We further determined if sympathetic NE uptake-1 (a major pathway to metabolize NE) mechanism is responsible for the role played by IBD. Methods: We ligated rat's coronary artery to induce CHF; and injected streptozotocin (STZ) to induce diabetic hyperglycemia. Echocardiography was employed to determine cardiac function. We used ELISA to examine plasma NE and BNP-45; and Western Blot analysis to examine the protein levels of NE uptake-1 in sympathetic nerves. Results: CHF increased the levels of NE and BNP-45 in non-STZ rats and STZ rats. Systemic injection of IBD significantly attenuated the augmented NE and BNP-45 and impaired left ventricular function induced by CHF in those rats. This effect appeared to be less in STZ rats. A liner relation was observed between the NE/BNP-45 levels and left ventricular function after administration of IBD. Also, IBD was observed to have a recovery effect on the downregulated NE uptake-1 evoked by CHF, but to a smaller degree in STZ rats. Conclusion: Our data revealed specific signaling mechanisms by which IBD improves the cardiac function as IBD alleviates impaired NE uptake-1and thereby decreases heightened NE and BNP-45 induced by CHF. Our data also demonstrated that the effects of IBD are weakened after diabetic hyperglycemia likely due to worsen NE uptake-1 pathway. Thus, targeting sympathetic NE uptake-1 signaling molecules has clinical implications for treatment and management of CHF in diabetes. Our data were also to shed light on strategies for application of this drug because NE and BNP play an important role in regulation of progression and prognosis of CHF, and in particular, because IBD affects NE uptake-1 pathway in hyperglycemic animals to a less degree.

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Diabetes and Coronary Heart Disease: A Risk Factor for the Global Epidemic

Cited by 84 publications

References 63 publications

Association between copeptin and declining glomerular filtration rate in people with newly diagnosed diabetes. The Skaraborg Diabetes Register

Association between copeptin and declining glomerular filtration rate in people with newly diagnosed diabetes. The Skaraborg Diabetes Register

Socio-economic Status of the Patients with Acute Coronary Syndrome: Data from a District-level General Hospital of Bangladesh

The Effects of Ivabradine on Cardiac Function after Myocardial Infarction are Weaker in Diabetic Rats

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