1979
DOI: 10.1007/bf01219790
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Diabetes and atherosclerosis ? The role of insulin

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Cited by 222 publications
(84 citation statements)
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References 101 publications
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“…24 ' M This hyperinsulinemia may predispose to vascular disease. 26 Our finding of a correlation of PA-inhibitor activity and BMI therefore strengthens the hypothesis recently formulated by Vague et al, 19 which states that the relative hyperinsulinism In obese Individuals, through its effects on PA-inhibltor activity, results in lower fibrlnotysls and thus enhanced development of vascular disease. In insulin-treated IDDM patients, who are also in a state of therapeutic" hyperinsulinism, the same mechanism might be operative as suggested by the correlation of insulin dose and PA-inhibltor activity (r = 0.4, p<0.05).…”
Section: Discussionsupporting
confidence: 76%
“…24 ' M This hyperinsulinemia may predispose to vascular disease. 26 Our finding of a correlation of PA-inhibitor activity and BMI therefore strengthens the hypothesis recently formulated by Vague et al, 19 which states that the relative hyperinsulinism In obese Individuals, through its effects on PA-inhibltor activity, results in lower fibrlnotysls and thus enhanced development of vascular disease. In insulin-treated IDDM patients, who are also in a state of therapeutic" hyperinsulinism, the same mechanism might be operative as suggested by the correlation of insulin dose and PA-inhibltor activity (r = 0.4, p<0.05).…”
Section: Discussionsupporting
confidence: 76%
“…1). Dies hat unter anderem zu Überlegungen über den Zusammenhang zwischen Hyperjnsulinämie und Makroangiopathie geführt (97 Normalpersonen (9) Nprmalpersonen (9) Altersdiabetiker (11) Altersdiabetiker (11) Normalpersonen (14) Normalpersoneri (14) Insulinpflichtige Diabetiker vor Insulin-Behandlung (10) Insulinpflichtige Diabetiker vor Insulin-Behandlung (10) Altersdiabetiker (9) Altersdiabetiker (9) Normalpersonen (24) Normälpersonen (24) juvenile Diabet. (17) juvenile Diabet.…”
Section: Die Periphere Resistenzlageunclassified
“…25 " 8 In attempts to elucidate atherogenic mechanisms associated with diabetes, most work has centered around characterization of alterations in lipid catabolism and associated changes in circulating lipoprotein patterns.…”
mentioning
confidence: 99%