DIA-based serum proteomics revealed the protective effect of modified siwu decoction against hypobaric hypoxia

Potential therapeutic effects of traditional Chinese medicine in acute mountain sickness: pathogenesis, mechanisms and future directions

“…Moreover, Fu et al found that qi-long-tian formula extract attenuated the inflammatory response in AMS model rats (6000 m, exposed to a Fenglei hypobaric hypoxic chamber for 72 h) by inhibiting HIF-1a, VEGF, suppressing the expression of inflammation-associated effectors (MMP9 and TIMP1), inhibiting the expression of target genes downstream of IL-17 (Ccl2, MMP9, S100a9, and S100a8), and attenuating lung injury and immune cell infiltration ( Fu et al, 2021 ). Our team also demonstrated that modified siwu decoction has a favorable protective effect against hypobaric hypoxia by down-regulating proteins associated with oxidative stress and the ubiquitin-proteasome system ((Superoxide dismutase 1, SOD1), (Catalase, CAT), GSTP1 and PRDX1), as well as by ameliorating hypoxia-induced upregulation of MDA and disturbances in energy and lipid metabolism ( Tu et al, 2023 ). Meanwhile, Zeng Y et al found that Huangqi Baihe Granules could significantly enhance lung function, reduce lung wet/dry ratio, alleviate lung tissue injury, inhibit the formation of ROS and MDA, and increase SOD activity and GSH expression, and its mechanism of action may be to inhibit the activation of TLR4/NF-κB p65/NLPR3 signaling pathway and reduce the release of downstream pro-inflammatory cytokines in lung tissue ( Zeng et al, 2024 ).…”