Di Guglielmo's Syndrome after Polycythemia

Transformation of Polycythemia Vera to Pure Erythroid Leukemia

“…PEL evolving from an MPN is exceedingly rare, with only a few cases reported to our knowledge. Between 1952 and 1962, five cases detailing the transformation of PV to PEL were documented in patients treated with radioactive phosphorus or alkylating agents [5][6][7][8]. Kreft et al reported a case of PEL arising from essential thrombocythemia (ET) [13].…”

“…To our knowledge, there are currently only a handful of reports of PEL arising from PV. Most reported cases have been associated with radiation therapy and chemotherapeutic alkylating agents [5][6][7][8]. Here we report a rare occurrence of polycythemia vera treated with phlebotomy and hydroxyurea that underwent leukemic transformation to pure erythroid leukemia.…”

Chronic lymphatic leukaemia terminating as erythroleukaemia

“…While the cytological typing of the acute leukaemia that develops in chronic lymphatic leukaemia may present a problem (Zarrabi, Rosner and Grunwald, 1979), in this case the bone marrow morphology was entirely distinct. While erythroblastic transformation is well recognized in myeloproliferative disorders (Rosenthal, Canellos and Grabruck, 1977;Scott, Ellison and Ley, 1964;Srodes, Hyde and Boggs, 1973;Bank, Larsen and Anderson, 1966;Dammert and Kaipainen, 1960), erythroleukaemia occurring in lymphoproliferations is rare but has occasionally been reported (Durant and Tassoni, 1967;Forbes, 1972;Cardamone, Kimmere and Marshall, 1974). The incrimination of chlorambucil therapy in the causation of malignancy remains difficult to establish in individual cases but has been demonstrated in certain patient groups (Berk et al, 1981;Griinwald, 1974, 1975;Carey, Holland and Sheene, 1967;Goldhirsch et al, 1980).…”