“…In addition, bisheterocyclic compounds exhibit various biological activities [9][10][11][12] and exert much higher antibacterial activity than heterocyclic compounds [13,14]. However, a literature survey revealed only p-(4,4-dipyrimidinyl)-benzene [15], p-(4,4-di(4-hydroxypyrimidinyl)-benzene [16], and 1,4-bis-(2-pyridone-6-yl)-benzene [17] have been prepared, which require drastic conditions and complex pathways. We have previously described the synthesis of di-(1,2,3,4-tetrahydropyrimidine) derivatives via the acid-catalyzed three-component condensation of benzene-1,4-dicarbaldehye with 1,3-dicarbonyl compounds or ethyl benzoylacetate and (thio)ureas [18,19].…”