Di(2-picolyl)amine-functionalized poly(ethylene glycol) hydrogels with tailorable metal–ligand coordination crosslinking

Abstract

A new class of metallo-hydrogels has been developed using di(2-picolyl)amine (DPA)-functionalized 4-arm polyethylene glycol (4A-PEG-DPAn) polymers crosslinked by metal–ligand coordination.

A review of recent advances in metal ion hydrogels: mechanism, properties and their biological applications

“…Yu et al used rheological experiments to prove that the Co 3+ obtained after Co 2+ oxidation formed highly stable coordination, which made the hydrogel have a more dense hydrogel network. 81 Temperature-responsiveness was another common property of metal ion hydrogels. Higher temperature will increase random thermal diffusion of metal ions, metal–ligand dynamic coordination was sensitive to temperature, and metal ion will not permanently locked in a polymer network.…”