Abstract:BackgroundIn recent years, new drugs have been approved for metastatic melanoma. The BRAF gene is the most common mutation in cutaneous melanomas and is present in 50% of melanomas. Vemurafenib and dabrafenib are used for the treatment of adult patients with unresectable or metastatic melanoma who are BRAF V600 mutation positive.PurposeTo analyse the use of the targeted anti-BRAF therapies, vemurafenib or dabrafenib, alone or combined with the MEK inhibitor trametinib or cobimetinib in a tertiary hospital in p… Show more
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