DHEAS improves learning and memory in aged SAMP8 mice but not in diabetic mice

Farr, Susan A.; Banks, William A.; Uezu, Kayoko; Gaskin, Frederich S.; Morley, John E.

doi:10.1016/j.lfs.2004.05.026

Cited by 35 publications

(18 citation statements)

References 39 publications

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“…These findings are consistent with reports on the positive association between DHEAS concentration and visuospatial abilities, verbal fluency and short-term memory (Rathna & Padma, 2013), suggesting a favorable role in cognitive aging. In animal models, DHEAS administration increased acetylcholine levels in the hippocampus of male rats, being hypothesized that it might promote neuroprotective mechanisms (Farr, Banks, Uezu, Gaski, & Morley, 2004). Further, no significant relationships were here found between DHEAS and mood.…”

Section: Discussionmentioning

confidence: 58%

The role of sex and sex-related hormones in cognition, mood and well-being in older men and women

Castanho

Moreira

Portugal‐Nunes

et al. 2014

Biological Psychology

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a b s t r a c tAlterations in hormone levels during aging impact on cognition and mood. Serum concentration levels of testosterone (TT), estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), dehydroepiandrosterone sulfate (DHEAS) and prolactin (PRL) were assessed in 120 community-dwellers (51+ years of age, males and females), in a cross-sectional approach. Performance clusters based on executive functioning (GENEXEC), memory (MEM), mood and well-being were obtained. In males, higher PRL levels associated with worse cognitive performance, lower well-being, and higher scores in depression scales, and lower E2 with poorer cognition and higher depressive mood. DHEAS positively associated with GENEXEC and MEM. Nutritional status significantly associated with PRL (positively) and with DHEAS (negatively). Findings indicate that besides the more exhaustively studied E2 and TT, variations in the levels of sex-related hormones such as PRL, FSH, LH and DHEAS are of interest for the mental health aging profile particularly in men.

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Section: Discussionmentioning

confidence: 58%

The role of sex and sex-related hormones in cognition, mood and well-being in older men and women

Castanho

Moreira

Portugal‐Nunes

et al. 2014

Biological Psychology

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“…32 Leptin receptors in the hippocampus appear to be involved in memory function; 17 direct administration of leptin into the hippocampus facilitates long-term potentiation and improves memory processing in mice. 33 Insulin receptors are also expressed in large concentrations in the hippocampus and are believed to be involved in memory function, possibly through their regulation of glucose transport. 34 Accordingly, glucose administration improves memory in both humans and animals.…”

Section: Discussionmentioning

confidence: 99%

Differences in response to food stimuli in a rat model of obesity: in-vivo assessment of brain glucose metabolism

et al. 2008

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Objective: Food intake is regulated by factors that modulate caloric requirements as well as food's reinforcing properties. In this study, we measured brain glucose utilization to an olfactory stimulus (bacon scent), and we examined the role of food restriction and genetic predisposition to obesity on such brain metabolic activity. Methods: Zucker obese (Ob) and lean (Le) rats were divided into four groups: (1) Ob ad-libitum fed, (2) Ob food restricted (70% of ad libitum), (3) Le ad-libitum fed and (4) Le food restricted. Rats were scanned using m-positron emission tomography and 2-[ 18 F]-fluoro-2-deoxy-D-glucose under two conditions: (1) baseline scan (no stimulation) and (2) challenge scan (food stimulation, FS). Results: FS resulted in deactivation of the right and left hippocampus. Ob rats showed greater changes with FS than Le rats (deactivation of hippocampus and activation of the medial thalamus) and Ob but not Le animals deactivated the frontal cortex and activated the superior colliculus. Access to food resulted in an opposite pattern of metabolic changes to the food stimuli in olfactory nucleus (deactivated in unrestricted and activated in restricted) and in right insular/parietal cortex (activated in unrestricted and deactivated in restricted). In addition, restricted but not unrestricted animals activated the medial thalamus. Conclusions: The greater changes in the Ob rats suggest that leptin modulates the regional brain responses to a familiar food stimulus. Similarly, the differences in the pattern of responses with food restriction suggest that FS is influenced by access to food conditions. The main changes with FS occurred in the hippocampus, a region involved in memory, the insular cortex, a region involved with interoception (perception of internal sensations), the medial thalamus (region involved in alertness) and in regions involved with sensory perception (olfactory bulb, olfactory nucleus, occipital cortex, superior colliculus and parietal cortex), which corroborates their relevance in the perception of food.

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“…Numerous transgenic or spontaneously transformed mouse, rat, or octodon degu lines Inestrosa et al 2005) have now succeeded in reproducing lesions in AD: the extracellular deposits of b-amyloid peptides (Ab) and the intracellular accumulation of tau protein (Zilka et al 2006), and most importantly cognitive impairments (Farr et al 2004;Hrnkova et al 2007). Although these are more specific models of the human AD, the cost of the transgene technology limits their applicability.…”

Section: Introductionmentioning

confidence: 99%

Intranasal Delivery of Human β-Amyloid Peptide in Rats: Effective Brain Targeting

et al. 2009

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(1) Intranasal administration is a non-invasive and effective way for the delivery of drugs to brain that circumvents the blood-brain barrier. The aims of the study were to test a nasal delivery system for human beta-amyloid (A beta) peptides, to measure the delivery of the peptides to brain regions, and to test their biological activity in rats. (2) A beta(1-42), in the form of a mixture of oligomers, protofibrils, and fibrils was dissolved in a nasal formulation containing hydrophobic, hydrophylic, and mucoadhesive components. The peptide solution was administered intranasally to rats as a single dose or in repeated doses. (3) Nasally injected A beta labeled with the blue fluorescent dye amino-methyl coumarinyl acetic acid (AMCA) could be detected by fluorescent microscopy in the olfactory bulb and frontal cortex. The concentration of the peptide was quantified by fluorescent spectroscopy, and a significant amount of AMCA-A beta peptide could be detected in the olfactory bulb. Unlabeled A beta also reached the olfactory bulb and frontal cortex of rats as evidenced by intense immunostaining. (4) In behavioral experiments, nasal A beta treatment did not affect anxiety levels (open-field test) and short-term memory (Y-maze test), but significantly impaired long-term spatial memory in the Morris water maze. The treatments did not result in A beta immunization. (5) The tested intranasal delivery system could successfully target a bioactive peptide into the central nervous system and provides a basis for developing a non-invasive and cost effective, new model to study amyloid-induced dysfunctions in the brain.

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DHEAS improves learning and memory in aged SAMP8 mice but not in diabetic mice

Cited by 35 publications

References 39 publications

The role of sex and sex-related hormones in cognition, mood and well-being in older men and women

The role of sex and sex-related hormones in cognition, mood and well-being in older men and women

Differences in response to food stimuli in a rat model of obesity: in-vivo assessment of brain glucose metabolism

Intranasal Delivery of Human β-Amyloid Peptide in Rats: Effective Brain Targeting

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