DHEA promotes osteoblast differentiation by regulating the expression of osteoblast-related genes and Foxp3&lt;sup&gt;+&lt;/sup&gt; regulatory T cells

Gui, Yuyan; Xu, Yuping; Li, Da‐Jin; Wang, Ling

doi:10.5582/bst.2015.01073

Cited by 22 publications

(16 citation statements)

References 33 publications

(26 reference statements)

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“…These discoveries prompted a need to examine the effects of SCFAs on bone volume in mice with normal gut microbiota (Figure 3). Tregs are suppressive CD4 + T cells that reside preferentially on the endosteal surfaces of bone (121); they are capable of suppressing osteoclastogenesis (107)(108)(109) and promoting osteoblast differentiation (122,123) and are required for parathyroid hormone-stimulated (PTH-stimulated) bone formation (124). The fact that SCFAs promote the differentiation of naive CD4 + cells into Tregs (56,90,91) suggests that SCFAs and probiotics that increase the production of SCFAs, such as Lactobacillus rhamnosus GG (LGG), may act through a pathway linking SCFAs, Tregs, and bone formation.…”

Section: Effects Of Scfas On Osteoclasts and Bone Resorptionmentioning

confidence: 99%

The gut-bone axis: how bacterial metabolites bridge the distance

Zaiss

Jones²,

Schett

et al. 2019

Journal of Clinical Investigation

214

195

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Section: Effects Of Scfas On Osteoclasts and Bone Resorptionmentioning

confidence: 99%

The gut-bone axis: how bacterial metabolites bridge the distance

Zaiss

Jones²,

Schett

et al. 2019

Journal of Clinical Investigation

214

195

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“…The effects of DHEA on Th17 and Treg are ambiguous [62] and dependent on tissue or disease context [66]: DHEA treatment increased the number of Foxp3+ Tregs in splenocytes of female ovariectomized mice [75]. In EAE model mice and human multiple sclerosis patients, DHEA directly inhibited the activity of Th17 cells, inducing IL-10-producing Tregs via ERβ activation [61].…”

Section: The Effects Of Sex Hormones On Immune Responsesmentioning

confidence: 99%

The Roles of Sex Hormones in the Course of Atopic Dermatitis

Kanda

Hoashi

Saeki

2019

IJMS

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Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by T helper 2 cell (Th2)-shifted abnormal immunity, skin barrier impairment, and pruritus. The prevalence of AD in childhood is slightly higher in boys than in girls; after puberty, the sexual difference is reversed. The female preponderance in all generations exists in intrinsic AD with enhanced Th1 activity and nickel allergy, lacking increased serum IgE or filaggrin mutation. AD is often deteriorated before menstruation. We review the effects of sex hormones on immune responses and skin permeability barrier and propose possible hypotheses for the above phenomena. After puberty, the immune responses of patients are remarkably influenced by sex hormones. Estrogen and progesterone enhance the activities of Th2/regulatory T cell (Treg) but suppress Th1/Th17. Androgens suppress Th1/Th2/Th17 and induce Treg. The skin permeability barrier is fortified by estrogen but is impaired by progesterone and androgens. Dehydroepiandrosterone suppresses Th2 but enhances Th1. The amount of steroid sulfatase converting dehydroepiandrosterone sulfate to dehydroepiandrosterone is higher in women than in men, and thus, women might be more susceptible to the influence of dehydroepiandrosterone. The balance of modulatory effects of sex hormones on immune responses and skin barrier might regulate the course of AD.

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“…29 Recent studies revealed the anti-osteoporotic function of DHEA in increasing osteoblast production and promoting the expression of osteoblastogenesis-related genes including Runx2, osterix, osteocalcin, and type I collagen in C57BL/6 mice mesenchymal stem cells. 30 Another study pointed out that DHEA apparently promoted proliferation and inhibited apoptosis of osteoblasts via MAPK signaling pathway in BALB/c mice osteoblastic cells. 31 DHEA was found to profoundly increase the ratio of OPG/RANKL mRNA in murine osteoblastic cells and inhibit the bone resorption of osteoclasts from BALB/c mice, which might be mediated via OPG/RANKL of osteoblasts.…”

Section: Chinese Herbal Formulas For Postmenopausal Osteoporosis 77mentioning

confidence: 99%

Chinese herbal formulas for postmenopausal osteoporosis: A review of preclinical evidence on animal studies and molecular mechanism

Lin

Tian

et al. 2018

Tradit. Med. Mod. Med.

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Whether Chinese herbal formulas are effective in treatment of postmenopausal osteoporosis remains unclear. The aim of this study is to explore the experimental evidence of both in vitro and in vivo preclinical studies using Chinese herbal formulas in postmenopausal osteoporosis. Searches were applied to various databases with relevant keywords. Original in vivo and in vitro studies using Chinese herbal formulas to treat postmenopausal osteoporosis, and with full text available, were included. Er-Xian Decoction, Bu-Shen-Ning-Xin Decoction, Qing E Formula, Liuwei Dihuang Wan, and Xian-Ling-Gu-Bao Decoction, the most commonly studied formulas, were selected from the pool of Chinese medicine. The preclinical data indicated the potential use of Chinese herbal formulas in postmenopausal osteoporosis. The underlying mechanisms included bone morphogenetic protein (BMP), Wnt/[Formula: see text]-catenin, extracellular-signal-regulated kinase/c-Jun [Formula: see text] terminal kinase/mitogen-activated protein kinase (ERK/JNK/MAPK), estrogen receptor (ER), and osteoprotegerin/receptor activator of nuclear factor [Formula: see text]B ligand (OPG/RANKL) signaling pathways. This study demonstrated the anti-osteoporotic effect of Chinese herbal formulas targeting different pathways in bone metabolism. Further study with adequate sample size and follow-up time, appropriate controls, and optimal blinding is required.

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DHEA promotes osteoblast differentiation by regulating the expression of osteoblast-related genes and Foxp3<sup>+</sup> regulatory T cells

Cited by 22 publications

References 33 publications

The gut-bone axis: how bacterial metabolites bridge the distance

The gut-bone axis: how bacterial metabolites bridge the distance

The Roles of Sex Hormones in the Course of Atopic Dermatitis

Chinese herbal formulas for postmenopausal osteoporosis: A review of preclinical evidence on animal studies and molecular mechanism

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