DHEA in Elderly Women and DHEA or Testosterone in Elderly Men

Nair, K. Sreekumaran; Rizza, Robert A.; O’Brien, Peter C.; Dhatariya, Ketan; Short, Kevin R.; Nehra, Ajay; Vittone, Janet L.; Klee, George G.; Basu, Ananda; Basu, Rita; Cobelli, Claudio; Toffolo, Gianna; Man, Chiara Dallla; Tindall, Donald J.; Melton, L. Joseph; Smith, Glenn E.; Khosla, Sundeep; Jensen, Michael D.

doi:10.1097/01.ogx.0000253416.67338.dc

Cited by 71 publications

(155 citation statements)

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“…However, in a double-blind, controlled crossover study of healthy young men receiving a 7-day course of oral DHEA (at a relatively high dose of 300 mg), improvements were observed in episodic memory and mood (Alhaj et al 2006). Other controlled studies, though, have shown no discernible benefits of DHEA supplementation even when the interventions are long term (Barnhart et al 1999;Nair et al 2006). It is quite possible that the low dose and/or brief regimen utilized in the present study were inadequate to appreciably affect subjective distress.…”

Section: Discussionmentioning

confidence: 89%

“…Depending on the endpoint and population in question, various behavioral effects have been demonstrated with doses as low as 25 mg and as high as 450 mg. Likewise, effects have been shown in some studies within a few days (Sageman and Brown 2006), yet in others effects have been evident only after several months of treatment (Balieu et al 2000) or not at all (Barnhart et al 1999;Nair et al 2006). A few studies have also shown beneficial effects in healthy individuals (Morales et al 1994;Kudielka et al 1998), typically with dose ranges of 50 -150 mg/day.…”

Section: Introductionmentioning

confidence: 89%

“…However, a double-blind, controlled crossover study of healthy young men receiving a 7-day course of oral DHEA (150 mg) led to improvements in episodic memory and mood-as well as reductions in evening cortisol levels (Alhaj et al 2006). Other controlled studies have shown no discernible benefits of DHEA supplementation, even when the interventions are long term (Barnhart et al 1999;Nair et al 2006).…”

Section: Introductionmentioning

confidence: 94%

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Effects of dehydroepiandrosterone supplementation during stressful military training: A randomized, controlled, double-blind field study

Taylor

Padilla

Stanfill

et al. 2011

Stress

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Dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) are anabolic prehormones involved in the synthesis of testosterone. Both have been shown to exert neuroprotective effects during stress. In this randomized, controlled, double-blind field study, we examined the effects of a 12-day DHEA regimen on stress indices in military men undergoing survival training. Forty-eight men were randomized to either a DHEA treatment group or placebo control group. The treatment group received 50 mg of oral DHEA supplementation daily for 5 days during classroom training followed by 7 days of 75 mg during stressful field operations. Control subjects received identical placebo pills. Salivary assays (DHEA[S], testosterone, and cortisol) were conducted at four time points: distal pre-stress (T1), proximal pre-stress (T2), mock-captivity stress (T3), and 24 h recovery (T4). Subjective distress was also assessed at T1, T3, and T4. As expected, DHEA treatment resulted in higher salivary concentrations of DHEA and DHEAS during daily living, mock-captivity stress, and recovery. Similar patterns were observed for salivary markers of anabolic balance: DHEA/cortisol, DHEAS/cortisol, and testosterone/cortisol concentration ratios. Despite notable time effects, no group differences emerged for subjective distress. A brief, low dose DHEA regimen yielded large increases in salivary DHEA(S) concentrations and enhanced anabolic balance throughout sustained military stress. These physiological changes did not extrapolate to subjective distress.

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Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 94%

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Effects of dehydroepiandrosterone supplementation during stressful military training: A randomized, controlled, double-blind field study

Taylor

Padilla

Stanfill

et al. 2011

Stress

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“…The suggestion of a positive effect of DHEA administration on physical and psychological parameters comes from some,9 – 11 but not all34 – 36 studies in elderly healthy participants and studies in a variety of disease states 12 – 18. Several of these studies had a small sample size,13 – 15 18 lacked a placebo controlled design,11 15 18 or did not analyse according to intention to treat 16 17.…”

Section: Discussionmentioning

confidence: 99%

Effect of dehydroepiandrosterone administration on fatigue, well-being, and functioning in women with primary Sjogren syndrome: a randomised controlled trial

Hartkamp

Geenen

Godaert

et al. 2008

Annals of the Rheumatic Diseases

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“…In a recent report, Nair et al (2006) describe treating a group of hypogonadal men for 24 months with a transdermal testosterone at a dose of 35 mg/week and finding no increase in strength. However, 35 mg/week is less than a replacement dose and resulted in only a 30% increase in the circulating testosterone concentration.…”

Section: Beneficial Effects Of Testosterone On Muscle and Bonementioning

confidence: 99%

Testosterone replacement therapy for older men

Borst

Mulligan²

2008

CIA

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Despite intensive research on testosterone therapy for older men, important questions remain unanswered. The evidence clearly indicates that many older men display a partial androgen deficiency. In older men, low circulating testosterone is correlated with low muscle strength, with high adiposity, with insulin resistance and with poor cognitive performance. Testosterone replacement in older men has produced benefits, but not consistently so. The inconsistency may arise from differences in the dose and duration of testosterone treatment, as well as selection of the target population. Generally, studies reporting anabolic responses to testosterone have employed higher doses of testosterone for longer treatment periods and have targeted older men whose baseline circulating bioavailable testosterone levels were low. Most studies of testosterone replacement have reported anabolic that are modest compared to what can be achieved with resistance exercise training. However, several strategies currently under evaluation have the potential to produce greater anabolic effects and to do so in a safe manner. At this time, testosterone therapy can not be recommended for the general population of older men. Older men who are hypogonadal are at greater risk for the catabolic effects associated with a number of acute and chronic medical conditions. Future research is likely to reveal benefits of testosterone therapy for some of these special populations. Testosterone therapy produces a number of adverse effects, including worsening of sleep apnea, gynecomastia, polycythemia and elevation of PSA. Efficacy and adverse effects should be assessed frequently throughout the course of therapy.

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DHEA in Elderly Women and DHEA or Testosterone in Elderly Men

Cited by 71 publications

References 0 publications

Effects of dehydroepiandrosterone supplementation during stressful military training: A randomized, controlled, double-blind field study

Effects of dehydroepiandrosterone supplementation during stressful military training: A randomized, controlled, double-blind field study

Effect of dehydroepiandrosterone administration on fatigue, well-being, and functioning in women with primary Sjogren syndrome: a randomised controlled trial

Testosterone replacement therapy for older men

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