1997
DOI: 10.1111/j.1532-5415.1997.tb02941.x
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DHEA: A Biologist's Perspective

Abstract: e recent extensive biomedical and lay public interest in T" dehydroepiandrosterone (DHEA) stems from the frequent suggestion that the marked age-related decline in the plasma level of dehydroepiandrosterone sulfate (DHEAS) in humans, discussed in this review, amounts to the development of a deficiency state for this hormone. Thus it has been proposed that replacement therapy with DHEA to restore youthful levels of DHEAS in older individuals might have beneficial effects on a variety of age-related conditions, … Show more

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Cited by 40 publications
(18 citation statements)
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References 96 publications
(103 reference statements)
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“…DHEA and DHEAS, which are collectively designated DHEA(S), are secreted in high amounts in humans and a few other primates. The highest reported plasma concentration of DHEA(S) in humans is about 10 M (Parker and Odell, 1980;Guillemette et al, 1996;Hornsby, 1997), which is close to our EC 50 value (6.7 M) for DHEA effect on the capsaicin response (Fig. 1B).…”
Section: Discussionsupporting
confidence: 71%
“…DHEA and DHEAS, which are collectively designated DHEA(S), are secreted in high amounts in humans and a few other primates. The highest reported plasma concentration of DHEA(S) in humans is about 10 M (Parker and Odell, 1980;Guillemette et al, 1996;Hornsby, 1997), which is close to our EC 50 value (6.7 M) for DHEA effect on the capsaicin response (Fig. 1B).…”
Section: Discussionsupporting
confidence: 71%
“…Only in humans and a few primates do the adrenals secrete dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) (69,70); in particular, the zona reticularis of the adrenal cortex is the exclusive source for DHEA and DHEAS, and the level of expression of 3b-hydroxysteroid dehydrogenase is the most important determinant for their biosynthesis (71).…”
Section: Dehydroepiandrosterone Sulfate (Dheas) and Agingmentioning
confidence: 99%
“…DHEA may be a reliable biomarker of aging specifically in men (Roth et al, 2002) and a potential predictor of mortality (Mazat et al, 2001). Hornsby (1997) makes the case that the most likely function for DHEA is as a precursor for conversion to potent androgens, which mediate adrenarchy, a sexual signaling mechanism occurring just before puberty in higher primates. The shrinkage of the DHEA-secreting tissue zone of the adrenal cortex and the decrease in DHEA levels could be considered as the post-pubertal involution of an organ whose function has been fulfilled and is no longer necessary, rather than as a phenomenon of aging or senescence.…”
Section: Dehydroepiandrosteronementioning
confidence: 99%
“…However, DHEA has been demonstrated to behave both as an antioxidant and a prooxidant, depending on the conditions of the experiment (Mooradian, 1993;Gallo et al, 1999). Both in vitro and in vivo, DHEA has been shown to protect against lipid peroxidation, cell death and toxicities induced by H 2 O 2 , carbon tetrachloride, copper, and hyperglycemia (Gallo et al, 1999;Bastianetto et al, 1999;Whitcomb and Schwartz, 1985;Rom and Harkin, 1991;Brignardello et al, 2000;Boccuzzi et al, 1997;Aragno et al, 1993;1997). In rats subjected to repeated immobilization stress, DHEA administration partly reversed stressinduced inhibition of body weight gain, increases in adrenal weight and glucocorticoid receptor levels, and decreased lipid peroxidation, suggesting that DHEA may act an anti-stress hormone by reducing free radical generation (Hu et al, 2000).…”
Section: Dehydroepiandrosteronementioning
confidence: 99%