DHA: An Excellent Source of Bioactive Heterocycles

Gupta, Girish Kumar; Mittal, Ankit; Kumar, Vinod

doi:10.2174/1570178610666131230235759

Cited by 12 publications

(9 citation statements)

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“…The pyran ring contains the carbonyl group named pyranone. The 2 nd position of the ketone group is named pyran‐2‐one, and the 4 th position is named pyran‐4‐one, some examples are shown in Figure 2 [29–30] . Benzo and naptho ring attached with pyranone same as pyran.…”

Section: Benzopyran Derivatives Nomenclaturementioning

confidence: 99%

“…According to the research literature studied, compound [N-(2-(6-fluoro-2H-chromen-8-yloxy)ethyl)-4-(4-methoxyphenyl)butanamine] (28) were synthesized and the structural modification of the benzopyran. The heterocyclic compounds 4,5-dihydropyranochromenes (29) are the impor-tant family of pharmaceutical chemistry used as a therapeutic agent in neurodegenerative diseases, Parkinson's disease, Alzheimer's disease, Down's syndrome, Huntington's disease, amyotrophic lateral sclerosis, AIDS-associated dementia. Moreover, it's also used for the treatment of myoclonus and schizophrenia.…”

Section: Origin-based Pyran Derivativesmentioning

confidence: 99%

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Insights into the Origin and Therapeutic Implications of Benzopyran and Its Derivatives

Tiwari

Singh

2023

ChemistrySelect

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Benzopyran derivatives are essential for life and are found abundantly in nature. Benzopyran compounds and their derivatives play an essential role in medicinal chemistry. The alkaloids, flavonoids, tocopherols, and anthocyanins natural products comprise benzopyran's basic structure. Various benzopyran derivatives have been used for therapeutic effects. Benzopyran derivatives can be proficient in various pharmaceutical applications for cellular markers. The basic structure of benzopyran is an efficient class of synthetic products and an emerging attention area of research. Therefore, impactful information on benzopyran and its derivatives has been compiled in the last several years. Recently, the development of novel benzopyran and its applications are contributing to medicines and pharmacy.

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Section: Benzopyran Derivatives Nomenclaturementioning

confidence: 99%

Section: Origin-based Pyran Derivativesmentioning

confidence: 99%

Insights into the Origin and Therapeutic Implications of Benzopyran and Its Derivatives

Tiwari

Singh

2023

ChemistrySelect

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“…Ketones obtained from pyrans are called pyranones (likewise regularly pyrones), the parent molecules being pyran-2-one and pyran-4-one. [11][12][13] Paltry names are utilised for the related benzo analogues; coumarin, dihydrocoumarin, chromone, xanthone, and chromanone or chroman-4-one.…”

Section: Benzopyrans and Fused Pyranbased Anticancer Scaffoldsmentioning

confidence: 99%

The value of pyrans as anticancer scaffolds in medicinal chemistry

et al. 2017

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“…Molecules with pyran‐2‐one core/nucleus constitute large family of biologically active compounds . Small changes, by substitution pattern, on the 2‐pyrone ring often lead to diverse biological properties .…”

Section: Introductionmentioning

confidence: 99%

Novel 3‐Hydroxy‐2‐naphthoic hydrazone and Ni(II), Co(II) and Cu(II) Complexes: Synthesis, Spectroscopic Characterization, Antimicrobial, DNA Cleavage and Computational Studies

Ekennia

Ibezim

Okpareke

et al. 2019

Applied Organom Chemis

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A novel hydrazone ligand derived from condensation reaction of 3-hydroxy-2naphthoic hydrazide with dehydroacetic acid, and its Ni(II), Cu(II) and Co(II) complexes were synthesized, characterized by spectroscopic, elemental analyses, magnetic susceptibility and conductivity methods, and screened for antimicrobial, DNA binding and cleavage properties. Spectroscopic analysis and elemental analyses indicated the formula, [MLCl 2 ], for the complexes; square planar geometry for the nickel, and tetrahedral geometry for copper and cobalt complexes. The non-electrolytic natures of the complexes in Dimethyl Sulphoxide (DMSO) were confirmed by their molar conductance values in the range of 6.11-14.01 Ω −1 cm 2 mol −1 . The copper complex had the best antibacterial activity against Staphylococcus aureus (ATCC 29213). DNA cleavage activities of the compounds, evaluated on pBR322 DNA, by agarose gel electrophoresis, in the presence and absence of oxidant (H 2 O 2 ) and free radical scavenger (DMSO), indicated no activity for the ligand, and moderate activity for the complexes, with the copper complex cleaving pBR322 DNA more efficiently in the presence of H 2 O 2 . When the complexes were evaluated for antibacterial and A-DNA activity using Molecular docking technique, the copper complex was found to be most effective against Gram-positive (S. aureus) bacteria. [CuLCl 2 ] showed good hydrogen bonding interaction with the major-groove (C 2 . G 13 base pair) of A-DNA. Density functional theory (DFT) calculations of the structural and electronic properties of the complexes revealed that [CuLCl 2 ] had a smaller HOMO-LUMO gap, suggesting a higher tendency to donate electrons to electron-accepting species of biological targets.

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DHA: An Excellent Source of Bioactive Heterocycles

Cited by 12 publications

References 0 publications

Insights into the Origin and Therapeutic Implications of Benzopyran and Its Derivatives

Insights into the Origin and Therapeutic Implications of Benzopyran and Its Derivatives

The value of pyrans as anticancer scaffolds in medicinal chemistry

Novel 3‐Hydroxy‐2‐naphthoic hydrazone and Ni(II), Co(II) and Cu(II) Complexes: Synthesis, Spectroscopic Characterization, Antimicrobial, DNA Cleavage and Computational Studies

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