DFT Investigation of the Interaction of Gold Nanoclusters with Nucleic Acid Base Guanine and the Watson−Crick Guanine-Cytosine Base Pair

Shukla, Manoj K.; Dubey, Madan; Zakar, Eugene; Leszczyński, Jerzy

doi:10.1021/jp808622y

Cited by 57 publications

(50 citation statements)

References 42 publications

(100 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The introduction of biological macromolecules (protein, DNA) can make the synthetic method of AuNCs greener and more biocompatible, which renders them more possible for biological application. Some reports have been published to make the affinity of DNA base pair and AuNCs evident theoretically [73,74], which provide the foundation for the subsequent experiments to verify the feasibility of theories. Chen and coworkers have unveiled atomically monodispersed AuNCs with direction of DNA as etchant of gold nanoparticles and rods [75].…”

Section: "Atoms To Clusters" Routementioning

confidence: 99%

Fluorescent Gold Nanoclusters: Synthesis and Recent Biological Application

et al. 2015

Journal of Nanomaterials

105

111

View full text Add to dashboard Cite

Fluorescent gold nanoclusters (AuNCs) have been extensively studied due to their unique construction and distinctive properties, which place them between single metal atoms and larger nanoparticles. The dimension of AuNCs is comparable to the Fermi wavelength of electrons, which lead to size-dependent fluorescence and other molecule-like properties. In this review, we summarize various synthesis strategies of fluorescent AuNCs and recent advances of biological applications such as biosensing, biolabeling, and bioimaging. The synthetic methods are considered as two routes: "Atoms to Clusters" and "Nanoparticles to Clusters. " The surface functionalization of AuNCs is described as the precondition for making future bioapplications possible, which can eventually influence their stability, biocompatibility, and other properties. And then we focus on the recent advances of AuNCs-based applications in biological sensing, biolabeling, and bioimaging and finally discuss the current challenges of AuNCs in controllable synthesis and biological application.

show abstract

Section: "Atoms To Clusters" Routementioning

confidence: 99%

Fluorescent Gold Nanoclusters: Synthesis and Recent Biological Application

et al. 2015

Journal of Nanomaterials

105

111

View full text Add to dashboard Cite

show abstract

“…Gold (Au) and silver (Ag) ions tend to have affinities for guanine (G) and cytosine (C) nucleotide bases of DNA and weaker interactions with adenine (A) and thymine (T) bases [51,[70][71][72][73]. Nucleotide bases of DNA interact with Ag and Au through Lewis acid-base coordination chemistry [72].…”

Section: Dna-mediated Metal Nanoclustersmentioning

confidence: 99%

Biomediated Atomic Metal Nanoclusters: Synthesis and Theory

Griep¹,

West²,

Sellers³

et al. 2015

Handbook of Nanoparticles

View full text Add to dashboard Cite

Fluorescent metal nanoclusters are an emerging class of multifunctional materials engineered at the singleatom level, with dimensions approaching the Fermi wavelength of electrons that offer competitive functionalities of traditional semiconductor QDs including tunable emission, ease of conjugation, extended photostability, and high quantum yield. With the additional advantages of being composed of nontoxic/ biocompatible materials, function with a fraction of the metal content, greatly reduced size for enhanced cellular uptake, opportunity for two-photon absorption at biologically relevant wavelengths, and demonstrated renal evacuation efficacy for in vivo applications, metal nanoclusters hold substantial promise. More recently the development of hybrid atomic cluster synthesis routes has expanded the materials' multifunctional capabilities. This chapter will summarize the current high-yield synthesis and functionalization strategies for producing monodisperse pure metal and hybrid nanocluster materials from both wet chemistry and newly developed biomediated nanocluster synthesis methodologies, involving protein and DNA hosts. The role of the bio-host and surface functional groups on the nanoclusters formation, stability, and physical properties will be detailed through recent experimental and theoretical simulation efforts.

show abstract

“…At the opposite end of the spectrum, the dimensions of the system can often be equally well reduced by considering isolated elements independent from the larger problem itself. In this case, the QM properties of nanoscale objects are often the only phenomena of importance from a modeling perspective 15, 66. This is particularly true when it comes to characterizing nanoscale objects in terms of their inherent physical and chemical properties.…”

Section: The Dimensions Of the Problemmentioning

confidence: 99%

Complex mathematical models of biology at the nanoscale

Bewick

Yang

Zhang

2009

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

Mathematical modeling of nanobiosystems is an exciting and rapidly growing new field of research that offers the potential to guide and improve technological developments in both nanomedicine and nanobiomaterial science. Unlike the more traditional fields of science and engineering, however, models of nanobiosystems are notoriously complex. In this paper, we highlight some of the primary sources of complexity in nanobiosystems. In particular, we focus on complexity that arises from the inherent nonlinearity of natural systems, noise generated by low copy numbers of relevant biological constituents, heterogeneity that stems from structure in physical systems at the nanoscale, strong coupling between processes that occur at different scales, and the large dimensions necessary to represent typical biological systems. We then suggest how different mathematical modeling techniques are currently being explored and developed to deal with the complicated and computationally demanding problems that can arise when modeling nanobiosystems. Although a relatively new field, mathematical descriptions of nanobiology are becoming increasingly more common and more important for both directing and interpreting experimental studies on nanobiosystems. The goal of this review is to emphasize the challenges associated with modeling nanobiosystems to inspire renewed effort in this highly interdisciplinary, but certainly rewarding, field.

show abstract

DFT Investigation of the Interaction of Gold Nanoclusters with Nucleic Acid Base Guanine and the Watson−Crick Guanine-Cytosine Base Pair

Cited by 57 publications

References 42 publications

Fluorescent Gold Nanoclusters: Synthesis and Recent Biological Application

Fluorescent Gold Nanoclusters: Synthesis and Recent Biological Application

Biomediated Atomic Metal Nanoclusters: Synthesis and Theory

Complex mathematical models of biology at the nanoscale

Contact Info

Product

Resources

About