Dezocine for Preventing Postoperative Pain: A Meta-Analysis of Randomized Controlled Trials

Abstract

BackgroundDezocine is considered to be an alternative medication for managing postoperative pain. The aim of this study was to assess the efficacy and safety of this drug in this regard.MethodsMedline, EMBASE and the Cochrane Central Register of Control Trials (CENTRAL) were searched to identify all randomized controlled trials (RCTs) that compare dezocine with placebo or dezocine with morphine on postoperative pain. The data were extracted and pooled using Mantel-Haenszel random effects model. Heterogeneity was tested using the I 2 statistic with values >50% and Chi2 test with P ≤ 0.05 indicating obvious heterogeneity between the studies.ResultsSeven trials evaluating 665 patients were included. The number of patients with at least 50% pain relief was increased (N = 234; RR 3.04, 95% CI 2.27 to 4.08) and physician (N = 465; RR 2.84, 95% CI 1.66 to 4.84) and patient satisfaction (N = 390; RR 2.81, 95% CI 1.85 to 4.26) were improved following the administration of dezocine compared with the placebo. The effects of dezocine were similar to those of morphine in terms of the number of patients reporting at least 50% pain relief within 2–6 h after surgery (N = 235; RR 1.29, 95% CI 1.15 to 1.46) and physician (N = 234; RR 1.18, 95% CI 0.93 to 1.49) and patient (N = 158; RR 1.33, 95% CI 0.93 to 1.92) satisfaction. While, the number of patients with at least 50% pain relief within 0–1 h after surgery increased following dezocine compared with morphine treatment (N = 79; RR 1.45, 95% CI 1.18 to 1.77). There was no difference in the incidence of postoperative nausea and vomiting (PONV) following dezocine treatment compared with the placebo (N = 391; RR 1.06, 95% CI 0.42 to 2.68) or morphine treatment (N = 235; RR 0.65, 95% CI 0.14 to 2.93).ConclusionDezocine is a promising analgesic for preventing postoperative pain, but further studies are required to evaluate its safety.

Effect of Scalp Nerve Block with Ropivacaine on Postoperative Pain in Patients Undergoing Craniotomy: A Randomized, Double Blinded Study

“…Also, these results could be related to the use of dezocine as a rescue analgesic in this study. Dezocine, an opioid receptor agonist-antagonist, has potency similar to that of morphine, with faster onset of action than morphine and less postoperative complications than morphine [31][32][33] . A recent meta-analysis, however, indicated the incidence of PONV was no different following dezocine treatment compared with placebo or morphine 33 .…”

Analgesic, anti-inflammatory and immuno-modulatory effects of dezocine-propofol anesthesia combination following colonoscopy

“…Thus the use of fentanyl after colonoscopy examination is not ideal. Pain relief after inspection is an outstanding feature of painless colonoscopy [9].…”

Comparison of Cardiovascular, Analgesic and Sedative Effects of Different Doses of Dezocine

“…Most importantly, study indicates that Dezocine can cause a significant increase in the number of patients with at least50% pain relief during the early postoperative period (within 0-1h) compared with morphine [1], which means that Dezocine may be a good choice for postoperative pain during anesthesia recovery period. Therefore, dezocine is gaining popularity in China as an alternative for postoperative pain [3]. Postoperative pain is one of many factors attributing to emergence agitation which is common that occurs during the early stage of recovery from general anesthesia [18].…”

“…Dezocine, as an opioidmu receptor partial agonist/antagonist, is considered to be an alternative medication for managing postoperative pain. Common adverse effects observed in opioids with full agonism are significantly reduced due to its partial agonism on the mu opioid receptor [1][2][3][4]. Similar to other opioids, Dezocine could decrease anesthetic requirement by up to 50% [5].…”

“…Similar to other opioids, Dezocine could decrease anesthetic requirement by up to 50% [5]. Because of above-mentioned reasons, although no longer used clinically in Western countries, Dezocine has been used widely in China as an alternative medication for postoperative pain management [3]. Micro vascular decompression (MVD) surgery has been regarded widely as a positive effective treatment method for hemi facial spasm (HFS) [6][7][8].…”