Dextromethorphan Inhibits Ischemia-induced c-fos  Expression and Delayed Neuronal Death in Hippocampal Neurons

Metabolism of Dextromethorphanin vitro: Involvement of Cytochromes P450 2D6 AND 3A3/4, with a Possible Role of 2E1

“…DMO has recently been described as potentially neuroprotective. 41,42 Neuroprotection appears to be linked to N-methyl-D-aspartate receptor blockade, which was shown to be a property of DOP. 43 DMO also exhibits anticonvulsant activity and it has been suggested that this eect results primarily from metabolism of DMO to its active metabolite DOP.…”

Dextromethorphan is Effective for Essential Blepharospasm

“…It can attenuate the glutamate-induced neurotoxicity and has a neuroprotective property against the ischemia-induced brain damage [8]. Dextromethorphan has many other medical applications, such as pain relief, psychological application, and the treatment of addiction [9].…”

Reduced Ischemia in the Medial Vestibular Nucleus after Premedication of Cilostazol and Ginkgo Biloba Extract in Global Hypoperfusion Rat Model

“…The results of numerous in vivo and in vitro studies have shown that induction of c-Fos protein precedes neuronal death and participates in neuronal injury after ischemia [14]. Likewise Renexin®, the dextromethorphan, a neuroprotective drug, reduced an expression of c-Fos protein one hour after ischemia, and also protected delayed neuronal degeneration in the CA 1 region of the hippocampus [15,16]. These results suggest that reduction of c-Fos expression one hour after ischemia may be positively correlated with survival of neurons.…”