Dextroamphetamine for Epilepsy

Livingston, Samuel; Pauli, Lydia L.

doi:10.1001/jama.1975.03260030068033

Cited by 21 publications

(5 citation statements)

References 6 publications

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“…However, these adverse effects are in practice very uncommon at doses typically used to treat posttraumatic cognitive impairments. Although lowering seizure threshold is often cited as a risk associated with the use of these agents, this risk appears to be minimal [186], even among persons with epilepsy [52,93].…”

Section: 4c Use Of Psychostimulants In Clinical Practicementioning

confidence: 99%

Pharmacotherapy of Posttraumatic Cognitive Impairments

Arciniegas

Silver

2006

Behavioural Neurology

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Pharmacotherapy may contribute to the rehabilitation of persons with posttraumatic cognitive impairments. This article reviews first the neurobiological consequences of traumatic brain injury with a particular emphasis on acute and long-term posttraumatic neurochemical disturbances. Studies of pharmacotherapies for posttraumatic cognitive impairments are reviewed next, and are organized according to medication class and the neurotransmitter system they affect most. Based on the evidence provided by that review, augmentation of posttraumatic cerebral catecholaminergic and cholinergic function are suggested as potentially useful neurochemical targets for pharmacologic intervention in this population. More specifically, it is suggested that persons with posttraumatic impairments in arousal, speed of processing, and possibly attention may benefit most from treatment with an agent that augments cerebral catecholaminergic function, and that persons whose predominant posttraumatic impairment is in the domain of memory may benefit most from treatment with cholinesterase inhibitors. Practical considerations regarding the use of pharmacotherapies for posttraumatic cognitive impairments are offered, and the need for additional research in this area is highlighted.

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Section: 4c Use Of Psychostimulants In Clinical Practicementioning

confidence: 99%

Pharmacotherapy of Posttraumatic Cognitive Impairments

Arciniegas

Silver

2006

Behavioural Neurology

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“…Similar symptoms in patients with dementia, closed head injury, attention-deficit disorder (ADD), AIDS, cerebral infarction, and metastatic disease have been successfully treated with neurostimulants such as methylphenidate (MPH) (1)(2)(3)(4)(5). In fact, neurostimulants such as d-amphetamines have been proven effective in the treatment of seizures (6,7).…”

Section: Introductionmentioning

confidence: 99%

An Evaluation of the Effects of Methylphenidate on Outcomes in Adult Epilepsy Patients

Moore

McAuley

Long

et al. 2002

Epilepsy & Behavior

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“…Historically, neurostimulants such as D-amphetamines have been proven effective in the treatment of seizures [2,9,10]. These sympathomimetic agents stimulate the central and peripheral nervous system.…”

Section: Discussionmentioning

confidence: 99%

“…Epileptic seizures have been reported to occur rarely with amphetamines but may occur after the first dosing [11]. Livingston et al, in a 1975 JAMA article, reported that amphetamines play a significant role in the treatment of the epileptic patient, particularly in diminishing or alleviating anticonvulsant druginduced drowsiness [10].…”

Section: Discussionmentioning

confidence: 99%