Dextro-transposition of great vessels: difficult to detect prenatally, one of the most dangerous and one of the best prognosed

Słodki, Maciej

doi:10.21037/tp-22-163

Cited by 3 publications

(2 citation statements)

References 39 publications

(65 reference statements)

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“…Moreover, in TGA, DRs range widely from 3% [ 20 ], 6.9% [ 21 ], and 20% “in many first world centers” [ 22 ] to 54% [ 23 ] and 72% (very high) [ 24 ]. Despite advances in fetal echocardiography and technologically impressive improvements, the PND of TGA is reported to be low in general [ 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Live-Birth Incidence of Isolated D-Transposition of Great Arteries—The Shift in Trends Due to Early Diagnosis

Stancioi-Cismaru,

Dinu,

Carp-Veliscu

et al. 2024

Diagnostics

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This is a single tertiary population-based study conducted at a center in southwest Romania. We retrospectively compared data obtained in two periods: January 2008–December 2013 and January 2018–December 2023. The global incidence of the transposition of great arteries in terminated cases, in addition to those resulting in live-born pregnancies, remained almost constant. The live-birth incidence decreased. The median gestational age at diagnosis decreased from 29.3 gestational weeks (mean 25.4) to 13.4 weeks (mean 17.2). The second trimester and the overall detection rate in the prenatal period did not significantly change, but the increase was statistically significant in the first trimester. The proportion of terminated pregnancies in fetuses diagnosed with the transposition of great arteries significantly increased (14.28% to 75%, p = 0.019).

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Section: Introductionmentioning

confidence: 99%

Live-Birth Incidence of Isolated D-Transposition of Great Arteries—The Shift in Trends Due to Early Diagnosis

Stancioi-Cismaru,

Dinu,

Carp-Veliscu

et al. 2024

Diagnostics

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“…In TGA also, DRs range widely: 3% [20], 6.9% [21], 20% "in many first world centers" [22], 54% [23] and very high -72% [24]. Despite advances in fetal echocardiography and the technological impressive improvement, the PND of TGA is reported as low in general [25,26].…”

mentioning

confidence: 99%

Live-Birth Incidence of Isolated D-Transposition of Great Arteries – the Shifted Trend Due to Early Diagnosis

Stancioi-Cismaru,

Dinu,

Carp-Veliscu

et al. 2024

Preprint

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This is a single tertiary center in southwest Romania, population-based, study. We retrospectively compared data obtained in two periods: January 2008 - December 2013 and January 2018 - De-cember 2023, respectively. The global incidence of transposition of great arteries (TGA) - the ter-minated cases added to the ones resulting in live-born pregnancies, remained almost constant. The live-born incidence of TGA decreased (0.34% to 0.013%). The prenatal detection rate increased slightly (71.42% to 87.5%). The median gestational age at the diagnosis decreased, from 29.3 ges-tational weeks (mean 25.4) to 13.4 weeks (mean 17.2). The proportion of terminated pregnancies significantly increased (14.28% to 75%, p = 0.019).

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Pathogenesis and Surgical Treatment of Dextro-Transposition of the Great Arteries (D-TGA): Part II

Zubrzycki,

Schramm,

Costard-Jäckle

et al. 2024

JCM

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Dextro-transposition of the great arteries (D-TGA) is the second most common cyanotic heart disease, accounting for 5–7% of all congenital heart defects (CHDs). It is characterized by ventriculoarterial (VA) connection discordance, atrioventricular (AV) concordance, and a parallel relationship with D-TGA. As a result, the pulmonary and systemic circulations are separated [the morphological right ventricle (RV) is connected to the aorta and the morphological left ventricle (LV) is connected to the pulmonary artery]. This anomaly is included in the group of developmental disorders of embryonic heart conotruncal irregularities, and their pathogenesis is multifactorial. The anomaly’s development is influenced by genetic, epigenetic, and environmental factors. It can occur either as an isolated anomaly, or in association with other cardiac defects. The typical concomitant cardiac anomalies that may occur in patients with D-TGA include ventriculoseptal defects, patent ductus arteriosus, left ventricular outflow tract obstruction (LVOTO), mitral and tricuspid valve abnormalities, and coronary artery variations. Correction of the defect during infancy is the preferred treatment for D-TGA. Balloon atrial septostomy (BAS) is necessary prior to the operation. The recommended surgical correction methods include arterial switch operation (ASO) and atrial switch operation (AtrSR), as well as the Rastelli and Nikaidoh procedures. The most common postoperative complications include coronary artery stenosis, neoaortic root dilation, neoaortic insufficiency and neopulmonic stenosis, right ventricular (RV) outflow tract obstruction (RVOTO), left ventricular (LV) dysfunction, arrhythmias, and heart failure. Early diagnosis and treatment of D-TGA is paramount to the prognosis of the patient. Improved surgical techniques have made it possible for patients with D-TGA to survive into adulthood.

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Dextro-transposition of great vessels: difficult to detect prenatally, one of the most dangerous and one of the best prognosed

Cited by 3 publications

References 39 publications

Live-Birth Incidence of Isolated D-Transposition of Great Arteries—The Shift in Trends Due to Early Diagnosis

Live-Birth Incidence of Isolated D-Transposition of Great Arteries—The Shift in Trends Due to Early Diagnosis

Live-Birth Incidence of Isolated D-Transposition of Great Arteries – the Shifted Trend Due to Early Diagnosis

Pathogenesis and Surgical Treatment of Dextro-Transposition of the Great Arteries (D-TGA): Part II

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