Dextrin-coated zinc substituted cobalt-ferrite nanoparticles as an MRI contrast agent: In vitro and in vivo imaging studies

Sattarahmady, N.; Zare, Tahereh; Mehdizadeh, Alireza; Azarpira, Negar; Heidari, Maryam; Lotfi, Mehrzad; Heli, H.

doi:10.1016/j.colsurfb.2015.03.021

Cited by 45 publications

(9 citation statements)

References 51 publications

(55 reference statements)

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“…1-Single phase magnetite is obtained at reaction temperatures above 50 [47]. Moreover, in order to produce of MNPs with high degree of crystallinity (evolution from amorphous to crystalline structure) and also formation of spinel structure, aging in the temperature range of 80 to 100 for at least 1 h is essential [48][49][50][51].…”

Section: Resultsmentioning

confidence: 99%

High impact of in situ dextran coating on biocompatibility, stability and magnetic properties of iron oxide nanoparticles

Shaterabadi

Nabiyouni

Soleymani

2017

Materials Science and Engineering: C

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Biocompatible ferrofluids based on dextran coated iron oxide nanoparticles were fabricated by conventional co-precipitation method. The experimental results show that the presence of dextran in reaction medium not only causes to the appearance of superparamagnetic behavior but also results in significant suppression in saturation magnetization of dextran coated samples. These results can be attributed to size reduction originated from the role of dextran as a surfactant. Moreover, weight ratio of dextran to magnetic nanoparticles has a remarkable influence on size and magnetic properties of nanoparticles, so that the sample prepared with a higher weight ratio of dextran to nanoparticles has the smaller size and saturation magnetization compare with the other samples. In addition, the ferrofluids containing such nanoparticles have an excellent stability at physiological pH for several months. Furthermore, the biocompatibility studies reveal that surface modification of nanoparticles by dextran dramatically decreases the cytotoxicity of bare nanoparticles and consequently improves their potential application for diagnostic and therapeutic purposes.

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Section: Resultsmentioning

confidence: 99%

High impact of in situ dextran coating on biocompatibility, stability and magnetic properties of iron oxide nanoparticles

Shaterabadi

Nabiyouni

Soleymani

2017

Materials Science and Engineering: C

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“…65 The signature peaks of the synthesized TMCDs has been listed (Table 1). 59,60 To understand the surface composition and electronic states of the constituent elements present in the EDA-functionalized TMCDs, XPS analysis was carried out (Figure 4). In common, 27 The deconvolution of O (1s) spectrum yielded a major peak at 531.6 ± 0.3 eV due to C=O (carbonyl linkages).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…The MRI relaxivities of EDA-functionalized TMCDs was measured by using agarose phantom. , Different concentration of transition metal ions in TMCDs ranging from 1–5 mM were suspended in agarose gel (1%, w/v) in a 48-well plate. For in vivo imaging, the zebrafish were anesthetized with tricaine (3-amino benzoic acidethylester) as per standard protocol and subsequently rapidly injected with 10 μL of 5 mg/mL EDA-functionalized TMCDs interperitonially by microloader pipet.…”

Section: Experimental Sectionmentioning

confidence: 99%

Transition Metal Ion (Mn²⁺, Fe²⁺, Co²⁺, and Ni²⁺)-Doped Carbon Dots Synthesized via Microwave-Assisted Pyrolysis: A Potential Nanoprobe for Magneto-fluorescent Dual-Modality Bioimaging

Pakkath¹,

Chetty²,

Praneetha³

et al. 2018

ACS Biomater. Sci. Eng.

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Heteroatom-doped carbon dots (C-dots) have captured widespread research interest owing to high fluorescence and biocompatibility for multimodal bioimaging applications. Here, we exemplify a rapid, facile synthesis of ethylenediamine (EDA)-functionalized transition metal ion (Mn2+, Fe2+, Co2+, and Ni2+)-doped C-dots via one-pot microwave (MW)-assisted pyrolysis at 800 W within 6 min using Citrus limon (lemon) extract as a carbon source. During MW pyrolysis, the precursor extract undergoes simultaneous carbonization and doping of metal ions onto C-dot surfaces in the presence of EDA. The EDA-functionalized transition metal ion-doped C-dots (i.e., Mn/C, Fe/C, Co/C, and Ni/C-dots) are collectively termed as TMCDs. The water-soluble TMCDs exhibited a size of 3.2 ± 0.485 nm and were enriched with amino and oxo functionalities and corresponding metal-oxide traces on the surfaces, as revealed from Fourier transfer infrared and X-ray photoelectron spectroscopy analyses. Interestingly, TMCDs demonstrated excitation-wavelength-dependent emission with brighter photoluminescence (PL) at 460 nm. Compared to pristine C-dots with a PL quantum yield (QY) of 48.31% and a fluorescence lifetime of 3.6 ns, the synthesized Mn/C, Fe/C, Co/C, and Ni/C-dots exhibited PL QY values of 35.71, 41.72, 75.07, and 50.84% as well as enhanced fluorescence lifetimes (τav) of 9.4, 8.6, 9.2, and 8.9 ns, respectively. The TMCDs significantly exhibited enhanced biocompatibility in human colon cancer cells (SW480) for fluorescence bioimaging and showed ferromagnetic and superparamagnetic behavior with vibrant T 1-contrast ability. Interestingly, the maximum longitudinal (r 1) relaxivity of 0.341 mM–1 s–1 was observed for Mn/C-dots in comparison to that of 3.1–3.5 mM–1 s–1 of clinically used Gd-DTPA magnetic resonance (MR)-contrast agent in vitro (1.5 T). Similarly, the maximum longitudinal relaxivity (r 1) of 0.356 mM–1 s–1 was observed for Ni/C-dots (1.5 T) with respect to 4.16 ± 0.02 mM–1 s–1 attained for Gd-DTPA in vivo (8.45 T). Thus, the rapid, energy-efficient MW-assisted pyrolysis presents lemon extract derived, EDA-functionalized TMCDs with enhanced PL and efficient T 1 contrast as potential magneto-fluorescent nanoprobes for dual-modality bioimaging applications.

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“…More frequently, iron oxide has served to provide MRI contrast while combined with other particles of varying utility. Examples include combination with iron-platinum nanoparticles in visualizing epidermoid and breast carcinoma [ 23 ], doping with zinc particles to improve contrast in breast carcinoma [ 24 ], formation of zinc–cobalt–ferrite nanoparticles to enhance the contrast effect seen with iron oxide alone in melanoma (C540 cell line) [ 25 ], and pairing with upconversion nanoparticles and gold particles in a dual modal imaging and photothermal therapy agent for breast carcinoma [ 26 ]. Perhaps the most common utilization of iron oxide as an MRI contrast agent has been as part of larger multi-agent nanoparticles with multimodal imaging and even therapeutic capability.…”

Section: Use Of Nanoparticles As a Diagnostic Imaging Toolmentioning

confidence: 99%

Nanoparticles as a Tool in Neuro-Oncology Theranostics

et al. 2021

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The rapid growth of nanotechnology and the development of novel nanomaterials with unique physicochemical characteristics provides potential for the utility of nanomaterials in theranostics, including neuroimaging, for identifying neurodegenerative changes or central nervous system malignancy. Here we present a systematic and thorough review of the current evidence pertaining to the imaging characteristics of various nanomaterials, their associated toxicity profiles, and mechanisms for enhancing tropism in an effort to demonstrate the utility of nanoparticles as an imaging tool in neuro-oncology. Particular attention is given to carbon-based and metal oxide nanoparticles and their theranostic utility in MRI, CT, photoacoustic imaging, PET imaging, fluorescent and NIR fluorescent imaging, and SPECT imaging.

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Dextrin-coated zinc substituted cobalt-ferrite nanoparticles as an MRI contrast agent: In vitro and in vivo imaging studies

Cited by 45 publications

References 51 publications

High impact of in situ dextran coating on biocompatibility, stability and magnetic properties of iron oxide nanoparticles

High impact of in situ dextran coating on biocompatibility, stability and magnetic properties of iron oxide nanoparticles

Transition Metal Ion (Mn²⁺, Fe²⁺, Co²⁺, and Ni²⁺)-Doped Carbon Dots Synthesized via Microwave-Assisted Pyrolysis: A Potential Nanoprobe for Magneto-fluorescent Dual-Modality Bioimaging

Nanoparticles as a Tool in Neuro-Oncology Theranostics

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Dextrin-coated zinc substituted cobalt-ferrite nanoparticles as an MRI contrast agent: In vitro and in vivo imaging studies

Cited by 45 publications

References 51 publications

High impact of in situ dextran coating on biocompatibility, stability and magnetic properties of iron oxide nanoparticles

High impact of in situ dextran coating on biocompatibility, stability and magnetic properties of iron oxide nanoparticles

Transition Metal Ion (Mn2+, Fe2+, Co2+, and Ni2+)-Doped Carbon Dots Synthesized via Microwave-Assisted Pyrolysis: A Potential Nanoprobe for Magneto-fluorescent Dual-Modality Bioimaging

Nanoparticles as a Tool in Neuro-Oncology Theranostics

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Transition Metal Ion (Mn²⁺, Fe²⁺, Co²⁺, and Ni²⁺)-Doped Carbon Dots Synthesized via Microwave-Assisted Pyrolysis: A Potential Nanoprobe for Magneto-fluorescent Dual-Modality Bioimaging