Dextran Sulphate, a Potent Anti-Hiv Agent in Vitro Having Synergism With Zidovudine

Ueno, Ryuji; Kuno, Sigeru

doi:10.1016/s0140-6736(87)90681-7

Cited by 203 publications

(77 citation statements)

References 3 publications

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“…Interest in these compounds increased when first studies on anti-human immunodeficiency virus (HIV) activities were published [5,6]. Most of the studies on the antiviral activity of polyanionic compounds, as well as their mode of action, were performed by De Clercq and co-workers [7].…”

Section: Introductionmentioning

confidence: 99%

Anionic Polysaccharides From Phototrophic Microorganisms Exhibit Antiviral Activities to Vaccinia Virus

Radonić¹,

Thulke²,

Achenbach³

et al. 2010

JAA

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Section: Introductionmentioning

confidence: 99%

Anionic Polysaccharides From Phototrophic Microorganisms Exhibit Antiviral Activities to Vaccinia Virus

Radonić¹,

Thulke²,

Achenbach³

et al. 2010

JAA

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“…Recently it was shown that dextran sulphate (OS) has anti-Hlv activity and acts synergistically with AZT (Ito et aI., 1989;Ueno and Kuno, 1987). PPS, like OS, is a negatively charged polysaccharide but has a lower molecular weight (4000 for PPS; >6000 for OS).…”

Section: Introductionmentioning

confidence: 99%

Sulphated Sugar Alpha-Cyclodextrin Sulphate, a Uniquely Potent Anti-HIV Agent, Also Exhibits Marked Synergism with AZT, and Lymphoproliferative Activity

Anand¹,

Nayyar

Pitha

et al. 1990

Antivir Chem Chemother

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Sulphated sugars, alpha-cyclodextrin sulphate (A-CDS), sodium pentosan polysulphate (PPS), and beta-cyclodextrin sulphate (B-CDS) were evaluated for their inhibitory effect on the replication of human immunodeficiency virus (HIV-1) in normal human peripheral blood mononuclear cells (PMNCs). All three drugs had potent anti-HIV activity, A-CDS being the most potent. A-CDS, PPS and B-CDS were also tested for their direct inhibitory effect on reverse transcriptase (RT) in vitro. PPS inhibited the RT reaction at 4.0 μg ml−1 and above whereas B-CDS and A-CDS did not. The drugs were not cytotoxic up to 100 μg ml−1 and also showed significant lymphoproliferative activities. PPS and B-CDS exhibited higher lymphoproliferative activity than A-CDS. A-CDS, B-CDS, and PPS showed profound antiviral synergism with AZT. An additive anti-HIV effect, rather than a synergestic effect, was observed between the sulphated sugars. Thus, these sulphated sugars, because of their nontoxic nature, lymphoproliferative activity and anti-HIV activity at low concentrations, may be valuable chemotherapeutic agents in the treatment of AIDS. In particular, A-CDS, because of its marked anti-HIV synergism with AZT (which would lower the required dose of AZT in vivo), could result in an efficacious and essentially nontoxic combination chemotherapy for AIDS.

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“…[66,67] In the late 1980s, studies indicated that dextran sulfates (1) and heparin (2) all had an inhibitory effect on HIV-1, however initially the mechanism by which these anionic polysaccharides caused inhibition of HIV was not known. [66,68] In 1988, two independent reports published within months of each other, reported that polyanions such as 1 and 2 reduced the HIV absorption (referred later to as 'entry') on to CD4þ host cells. [69,70] In addition, the study showed that dextran sulfate chain length has no effect on efficacy, however the chain lengths of 2 had a profound effect on HIV-1 inhibition where unfragmented heparin (M w % 15 000 g Á mol À1 ) and long chain fragmented heparin (M w % 11 000 g Á mol À1 ) had the highest efficacy.…”

Section: Polysaccharide Entry Inhibitorsmentioning

confidence: 99%

Polymeric Anti‐HIV Therapeutics

Danial

Klok

2014

Macromolecular Bioscience

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The scope of this review is to highlight the application of polymer therapeutics in an effort to curb the transmission and infection of the human immunodeficiency virus (HIV). Following a description of the HIV life cycle, the use of approved antiretroviral drugs that inhibit critical steps in the HIV infection process is highlighted. After that, a comprehensive overview of the structure and inhibitory properties of polymeric anti‐HIV therapeutic agents is presented. This overview will include inhibitors based on polysaccharides, synthetic polymers, dendritic polymers, polymer conjugates as well as polymeric DC‐SIGN antagonists. The review will conclude with a section that discusses the applications of polymers and polymer conjugates as systemic and topical anti‐HIV therapeutics.

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Dextran Sulphate, a Potent Anti-Hiv Agent in Vitro Having Synergism With Zidovudine

Cited by 203 publications

References 3 publications

Anionic Polysaccharides From Phototrophic Microorganisms Exhibit Antiviral Activities to Vaccinia Virus

Anionic Polysaccharides From Phototrophic Microorganisms Exhibit Antiviral Activities to Vaccinia Virus

Sulphated Sugar Alpha-Cyclodextrin Sulphate, a Uniquely Potent Anti-HIV Agent, Also Exhibits Marked Synergism with AZT, and Lymphoproliferative Activity

Polymeric Anti‐HIV Therapeutics

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