Dextran, Oxypolygelatin and Modified Fluid Gelatin as Replacement Fluids in Experimental Hemorrhage

Parkins, W. M.; Perlmutt, Joseph H.; Vars, Harry M.

doi:10.1152/ajplegacy.1953.173.3.403

Cited by 11 publications

(5 citation statements)

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“…This observation serves t o confirm a preliminary report of this work (11) and the results of several other investigators (13,16,10,17).…”

Section: Discussionsupporting

confidence: 91%

The Effects of Single Large Infusions of Various Dextran Solutions on Hypovolemic Dogs

Semple

1954

Can. J. Biochem. Physiol.

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Standardized bleeding procedures were carried out on anesthetized dogs. Some animals received no therapy, some infusions of saline, and some received dextran infusions a t times that varied from immediately to three and one-half hours after hemorrhage. With no therapy, one of eight animals survived; with saline infusions, 4 of 13 s~~r v i v e d ;and with dextran 23 of 24 dogs survived. 'There was often wountl bleeding after dextran; this was not seen in saline treated animals but dextran treated animals recovered rapidly and no other ill-effects were noted. nextran infusions were quantitatively retained in the circulation for a n appreciable time and the volume and pressure of the circulating fluid were effectively restored and maintained. The amount of dextran excreted in urine was inversely related to the mean molecular weight of the infused material and the quantity excreted was the same a s that observed in normal animals. The rate of disappearance of dextran by other than the renal route did not vary with the mean molecular weight, and indicated that the dextran molecule is catabolized a t from 4 . 9 t o 8 . 6 mgm./hr./kgm. body weight. About SOYo of total plasma proteins of animals was lost by the hemorrhage and was replaced, after dextran infusions, within four days. 'There was no evidence, after dextran infusions, of dextran storage in kidney, spleen, or liver.

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“…This observation serves t o confirm a preliminary report of this work (11) and the results of several other investigators (13,16,10,17).…”

Section: Discussionsupporting

confidence: 91%

The Effects of Single Large Infusions of Various Dextran Solutions on Hypovolemic Dogs

Semple

1954

Can. J. Biochem. Physiol.

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“…Being one of the first synthetic colloids used for fluid resuscitation in humans [2], it came into more widespread use when different modifications of the gelatin molecules became available (oxypolygelatin [3], succinylated or modified fluid gelatin [4], and urea-linked gelatin [5]). These products entered the market long before current regulatory rules requiring proof of efficacy and safety of drugs came into existence [6].…”

Section: Introductionmentioning

confidence: 99%

Safety of gelatin for volume resuscitation—a systematic review and meta-analysis

et al. 2012

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“…Gelatin-based colloid fluids have been in clinical use since the 1950s (121) and continue to maintain a presence among current fluid choices. There are three different types of gelatin that have been used over the years: oxypolygelatin, modified fluid gelatin (succinylated gelatin), and urea-linked gelatin (polygeline).…”

Section: Gelatinmentioning

confidence: 99%

Intravenous Fluid Administration and the Coagulation System

2021

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Intravenous fluid administration in veterinary patients can alter coagulation function by several mechanisms. Both crystalloid and colloid fluids cause hemodilution, reducing platelet count and plasma coagulation protein concentrations. Hemodilution is associated with a hypercoagulable effect at low dilutions and a hypocoagulable effect at higher dilutions. Composition of crystalloid fluids likely has a minor effect, primarily dependent on fluid ion composition. Hypertonic crystalloids may also cause hypocoagulability. Colloids, both synthetic and natural, can cause hypocoagulability by several mechanisms beyond the effects of hemodilution. These include impaired platelet function, decreased plasma coagulation factor activity, impaired fibrin formation and crosslinking, and accelerated fibrinolysis. The vast majority of the veterinary literature investigates the hypocoagulable effects of hydroxyethyl starch–containing fluids using in vitro, experimental, and clinical studies. However, results are inconsistent, likely due to the varying doses and physicochemical properties of the specific fluid products across studies. In addition, some evidence exists for hypocoagulable effects of gelatin and albumin solutions. There is also evidence that these colloids increase the risk of clinical bleeding in people. Limitations of the veterinary evidence for the hypocoagulable effects of colloid fluids include a predominance of in vitro studies and in vivo studies using healthy subjects, which exclude the interaction of the effects of illness. Therefore, clinical relevance of these effects, especially for low-molecular-weight hydroxyethyl starch, is unknown. Firm recommendations about the most appropriate fluid to use in clinical scenarios cannot be made, although it is prudent to limit the dose of synthetic colloid in at-risk patients. Clinicians should closely monitor relevant coagulation assays and for evidence of hemorrhage in at-risk patients receiving any type of fluid therapy, especially in large volumes.

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Dextran, Oxypolygelatin and Modified Fluid Gelatin as Replacement Fluids in Experimental Hemorrhage

Cited by 11 publications

References 0 publications

The Effects of Single Large Infusions of Various Dextran Solutions on Hypovolemic Dogs

The Effects of Single Large Infusions of Various Dextran Solutions on Hypovolemic Dogs

Safety of gelatin for volume resuscitation—a systematic review and meta-analysis

Intravenous Fluid Administration and the Coagulation System

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