Dextran-Coated Iron Oxide Nanoparticles as Biomimetic Catalysts for Localized and pH-Activated Biofilm Disruption

Naha, Pratap C.; Liu, Yuan; Hwang, Geelsu; Huang, Yue; Gubara, Sarah M.; Jonnakuti, Venkata; Simón-Soro, Áurea; Kim, Dongyeop; Gao, Lizeng; Koo, Hyun; Cormode, David P.

doi:10.1021/acsnano.8b08702

Cited by 272 publications

(264 citation statements)

References 70 publications

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“…In addition, nanoparticles can mediate EPS matrix degradation through an enzyme‐like activity which causes the biofilm to disperse, i.e., the bacteria are separated from the biofilm and are thus in a free‐floating state. Bacteria dispersed from biofilms lose the inherent protection of biofilm colonies, and the interaction between bacteria in the biofilm is also destroyed.…”

Section: Antibiofilm Mechanisms Of Nanoparticles At Different Stagesmentioning

confidence: 99%

Nanoparticles for the Treatment of Oral Biofilms: Current State, Mechanisms, Influencing Factors, and Prospects

Wang

Yuan

et al. 2019

Adv Healthcare Materials

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Due to their excellent size, designability, and outstanding targeted antibacterial effects, nanoparticles have become a potential option for controlling oral biofilm‐related infections. However, the formation of an oral biofilm is a dynamic process, and factors affecting the performance of antibiofilm treatments are complex. As such, when examining the existing literature on the antibiofilm effects of nanoparticles, attention should be paid to the specific mechanisms of action at different stages of oral biofilm formation, as well as relevant influencing factors, in order to achieve an objective and comprehensive evaluation. This review is intended to detail the antibacterial mechanisms of nanoparticles during the four stages of the formation of oral biofilms: 1) acquired film formation; 2) bacterial adhesion; 3) early biofilm development; and 4) biofilm maturation. In addition, factors influencing the antibiofilm properties of nanoparticles are summarized from the aspects of nanoparticles themselves, biofilm models, and host factors. The limitations of current research and possible trends for future research are also discussed. In summary, nanoparticles are a promising antioral biofilm strategy. It is hoped that this review can serve as a reference and inspire ideas for further research on the application of nanoparticles for effectively targeting and treating oral biofilms.

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Section: Antibiofilm Mechanisms Of Nanoparticles At Different Stagesmentioning

confidence: 99%

Nanoparticles for the Treatment of Oral Biofilms: Current State, Mechanisms, Influencing Factors, and Prospects

Wang

Yuan

et al. 2019

Adv Healthcare Materials

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“…Among the biomimetic enzymes, the iron nanoparticles possess a peroxidase‐like activity and the most commonly used strategy in antimicrobial treatments . The colloidal ironic nanoparticles alone is not quite stable, thus, in applications, the iron nanoparticles are normally coated with some hydrophilic polymers, like dextran, to enhanced their bioaccessibility. The acidic pH environment produced by pathogens, like S. mutans , could enhance the activity of iron nanoparticles in producing the hydroxyl radicals, which can induce the lysis of bacteria as well as the degradation of the biofilm matrix .…”

Section: Adaptive Antimicrobial‐delivery Systemsmentioning

confidence: 99%

“…The colloidal ironic nanoparticles alone is not quite stable, thus, in applications, the iron nanoparticles are normally coated with some hydrophilic polymers, like dextran, to enhanced their bioaccessibility. The acidic pH environment produced by pathogens, like S. mutans , could enhance the activity of iron nanoparticles in producing the hydroxyl radicals, which can induce the lysis of bacteria as well as the degradation of the biofilm matrix . While under physiological pH, the hydroxyl radical generation efficiency is negligible, minimizing their effects to the normal tissues.…”

Section: Adaptive Antimicrobial‐delivery Systemsmentioning

confidence: 99%

Recent Advances and Future Prospects on Adaptive Biomaterials for Antimicrobial Applications

Liu

et al. 2019

Macromolecular Bioscience

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Bacterial infection is becoming the biggest threat to human health. The scenario is partly due to the ineffectiveness of the conventional antibiotic treatments against the emergence of multidrug‐resistant bacteria and partly due to the bacteria living in biofilms or cells. Adaptive biomaterials can change their physicochemical properties in the microenvironment of bacterial infection, thereby facilitating either their interactions with bacteria or drug release. The trends in treating bacterial infections using adaptive biomaterials‐based systems are flourishing and generate innumerous possibility to design novel antimicrobial therapeutics. This feature article aims to summarize the recent developments in the formulations, mechanisms, and advances of adaptive materials in bacterial infection diagnosis, contact killing of bacteria, and antimicrobial drug delivery. Also, the challenges and limitations of current antimicrobial treatments based on adaptive materials and their clinical and industrial future prospects are discussed.

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“…Metallic and oxidic nanoparticles and nanoporous systems provide excellent catalysts for oxidation reactions. In particular, nanoparticles have acquired a lot of attention as catalysts for the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) by hydrogen peroxide [1][2][3][4] since the catalytic activity of metallic nanoparticles can be compared to the one of peroxidase [5][6][7][8][9] for the same reaction ("artificial enzymes", cf. Refs.…”

Section: Introductionmentioning

confidence: 99%

“…[7] There is a large number of studies in which this approach has been adopted. [3,4,[22][23][24] However, doubts may be raised about the general validity of such a kinetic treatment: First of all, this approach interprets only the initial rate of the reaction, that is, the rate at very low conversion. The restriction to the initial rates may be justified in case of complicated biochemical reactions but not for a model reaction that can be followed to high conversion.…”

Section: Introductionmentioning

confidence: 99%

Mechanism of the Oxidation of 3,3′,5,5′‐Tetramethylbenzidine Catalyzed by Peroxidase‐Like Pt Nanoparticles Immobilized in Spherical Polyelectrolyte Brushes: A Kinetic Study

Risse

Lü

et al. 2020

ChemPhysChem

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Experimental and kinetic modelling studies are presented to investigate the mechanism of 3,3′,5,5′‐tetramethylbenzidine (TMB) oxidation by hydrogen peroxide (H2O2) catalyzed by peroxidase‐like Pt nanoparticles immobilized in spherical polyelectrolyte brushes (SPB−Pt). Due to the high stability of SPB−Pt colloidal, this reaction can be monitored precisely in situ by UV/VIS spectroscopy. The time‐dependent concentration of the blue‐colored oxidation product of TMB expressed by different kinetic models was used to simulate the experimental data by a genetic fitting algorithm. After falsifying the models with abundant experimental data, it is found that both H2O2 and TMB adsorb on the surface of Pt nanoparticles to react, indicating that the reaction follows the Langmuir–Hinshelwood mechanism. A true rate constant k, characterizing the rate‐determining step of the reaction and which is independent on the amount of catalysts used, is obtained for the first time. Furthermore, it is found that the product adsorbes strongly on the surface of nanoparticles, thus inhibiting the reaction. The entire analysis provides a new perspective to study the catalytic mechanism and evaluate the catalytic activity of the peroxidase‐like nanoparticles.

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Dextran-Coated Iron Oxide Nanoparticles as Biomimetic Catalysts for Localized and pH-Activated Biofilm Disruption

Cited by 272 publications

References 70 publications

Nanoparticles for the Treatment of Oral Biofilms: Current State, Mechanisms, Influencing Factors, and Prospects

Nanoparticles for the Treatment of Oral Biofilms: Current State, Mechanisms, Influencing Factors, and Prospects

Recent Advances and Future Prospects on Adaptive Biomaterials for Antimicrobial Applications

Mechanism of the Oxidation of 3,3′,5,5′‐Tetramethylbenzidine Catalyzed by Peroxidase‐Like Pt Nanoparticles Immobilized in Spherical Polyelectrolyte Brushes: A Kinetic Study

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