Dextran Coated Cerium Oxide Nanoparticles for Inhibiting Bone Cancer Cell Functions

Alpaslan, Ece; Yazıcı, Hilal; Golshan, Negar H.; Ziemer, Katherine S.; Webster, Thomas J.

doi:10.1002/9781119190134.ch17

Cited by 3 publications

(4 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They were not toxic to the cell lines T98G (from a human glioblastoma multiform tumor) but caused cell death to BEAS-2B cell line (Park et al, 2008) and human bronchoalveolar carcinoma derived cell line (A549) (Lin et al, 2006) by an apoptotic process, mainly by increasing the levels of ROS and decreasing the levels of GSH and α-tocopherol. In the study of Alpaslan et al (2015), the dextran-coated nanoceria killed much more effectively the osteosarcoma cell line MG-63 (ATCC CRL-1427) than the osteoblast noncancerous cell line (PromoCell, C-12720), suggesting that nanoceria can promisingly be used for treating bone cancer without the appearance of adverse effects to healthy bone cells. CeO 2 NPs showed a rapid uptake from human keratinocyte cells (HaCaT) and co-localized with mitochondria, lysosomes, endoplasmic reticulum, cytoplasm, and nucleus, suggesting that they act as cellular antioxidants in multiple compartments (Singh et al, 2010).…”

Section: Cytotoxicity Of Rare Earth Elementsmentioning

confidence: 99%

Toxicity of rare earth elements: An overview on human health impact

Brouziotis

Giarra

Libralato

et al. 2022

Front. Environ. Sci.

View full text Add to dashboard Cite

Rare earth elements (REEs) are metals including the 15 lanthanides together with Yttrium and Scandium. China is the leading country in their exploitation and production (∼90%). REEs are necessary for the production of several technological devices. This extended use of REEs has raised concerns about human health safety. In this review, we investigated the hazard of REEs to human health and the main gaps into the knowledge like as the need to develop further focused research activity. We categorized the research papers collected into eight main sections: environmental exposure, association of REEs with health problems, exposure to REEs due to lifestyle, REE exposure through the food chain, Gd contrast agents causing health problems, occupational REE exposure, and cytotoxicity studies of REEs. This review provided information about the exposome of REEs (the exposure of REEs to the human body), the existing research data, and the gaps that require attention and must be further investigated. More than one third of the literature about REE toxicity to human health concerns their cytotoxicity to human cell lines, while hair, blood serum and blood are the most studied matrices. The main results evidenced that REEs can enter human body via several routes, are associated with numerous diseases, can cause ROS production, DNA damage and cell death, and are more toxic to cancer cells than normal cells.

show abstract

Section: Cytotoxicity Of Rare Earth Elementsmentioning

confidence: 99%

Toxicity of rare earth elements: An overview on human health impact

Brouziotis

Giarra

Libralato

et al. 2022

Front. Environ. Sci.

View full text Add to dashboard Cite

show abstract

“…86 For example, in Colorectal Carcinoma Cells, CeO 2 -NPs can induce DNA fragmentation by increasing the production of ROS, resulting in cellular apoptosis through the p53-dependent mitochondrial signaling pathway. 84 Yazici et al 87,88 discovered positive effects to varying degrees on osteosarcoma when they studied the cytotoxicity of 0.1 M and 0.01 M dextrancoated CeO 2 -NPs based on dose and time dependence. After that, the results found that at pH 6.0, CeO 2 -NPs were the most damaging to bone cancer cells and the least damaging to healthy bone cells.…”

Section: Osteosarcomamentioning

confidence: 99%

<p>The Advances of Ceria Nanoparticles for Biomedical Applications in Orthopaedics</p>

Li¹,

Xia²,

S³

et al. 2020

IJN

View full text Add to dashboard Cite

The ongoing biomedical nanotechnology has intrigued increasingly intense interests in cerium oxide nanoparticles, ceria nanoparticles or nano-ceria (CeO 2-NPs). Their remarkable vacancy-oxygen defect (VO) facilitates the redox process and catalytic activity. The verification has illustrated that CeO 2-NPs, a nanozyme based on inorganic nanoparticles, can achieve the anti-inflammatory effect, cancer resistance, and angiogenesis. Also, they can well complement other materials in tissue engineering (TE). Pertinent to the properties of CeO 2-NPs and the pragmatic biosynthesis methods, this review will emphasize the recent application of CeO 2-NPs to orthopedic biomedicine, in particular, the bone tissue engineering (BTE). The presentation, assessment, and outlook of the orthopedic potential and shortcomings of CeO 2-NPs in this review expect to provide reference values for the future research and development of therapeutic agents based on CeO 2-NPs.

show abstract

“…CNPs have shown to scavenge the reactive oxygen species (ROS) and have shown its promise to cure several oxidative stress related disorders [5]. CNPs have also shown their inhibitory effect on cancer progression being toxic to tumor cells and nontoxic to stromal cells and were investigated as a potential nanomedicine for cancer treatment [6][7][8]. Optimal therapeutic performance of these nanoparticles needs a well and stable biological dispersion throughout the duration of treatment and remains a major obstacle in its application [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…The sedimentation goes faster with increasing of the nanoparticle concentration. In order to overcome these drawbacks, synthesis of biocompatible CNPs in pure water, citrate, cyclodextrin, polymers and surface modification using few functionalizing moieties such as polyethylene glycol and heparin have already been reported [7,[12][13][14]. Most of those protecting agents were found to be either readily washed off or reduce the catalytic activity of the nanoparticles upon exposure to physiological condition and ended up with short circulation time in in vivo environment [9,15].…”

Section: Introductionmentioning

confidence: 99%

Covalent Surface Modification of Cerium Oxide Nanoparticles Promising for Nanomedicine Application

Nanda

2016

Preprint

View full text Add to dashboard Cite

Cerium Oxide Nanoparticles (CNPs) have been emerged as a potential nanomedicine for treatment of several diseases including cancer. CNPs have the natural tendency to aggregate or agglomerate at its bare state and led to sedimentation at biological environment. Since the biological environment is essentially aqueous, nanoparticle surface modification using suitable biocompatible hydrophilic chemical moiety is highly desirable for its stable aqueous dispersion. In this report, we have used (6-{2-[2-(2-Methoxy-ethoxy)-ethoxy]-ethoxy}-hexyl)triethoxysilane to engineer the CNP's surface for production of improved grade nanoparticles for potential nano-biological

show abstract

Dextran Coated Cerium Oxide Nanoparticles for Inhibiting Bone Cancer Cell Functions

Cited by 3 publications

References 22 publications

Toxicity of rare earth elements: An overview on human health impact

Toxicity of rare earth elements: An overview on human health impact

<p>The Advances of Ceria Nanoparticles for Biomedical Applications in Orthopaedics</p>

Covalent Surface Modification of Cerium Oxide Nanoparticles Promising for Nanomedicine Application

Contact Info

Product

Resources

About