Dextran-based polyelectrolyte multilayers: Effect of charge density on film build-up and morphology

Delvart, Aurore; Moreau, Céline; D’Orlando, Angélina; Falourd, Xavier; Cathala, Bernard

doi:10.1016/j.colsurfb.2021.112258

Cited by 8 publications

(11 citation statements)

References 72 publications

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“…Over the last decades, a huge number of macromolecules, including natural polymers, were considered as constituents for drug-delivery systems (DDS) in different formulations: microspheres [ 1 , 2 ], microparticles [ 3 , 4 ], nanoparticles (NPs) [ 5 ], nanodroplets [ 6 ], liposomes [ 7 ], micelles [ 8 , 9 ] and nanomicelles [ 9 ], hydrogels [ 10 , 11 , 12 ], films [ 13 , 14 ], nanowires [ 15 ], bio-conjugates [ 16 ], medical adhesives [ 17 ] and others [ 18 , 19 , 20 ]. Among natural polymers, polysaccharides are one of the most utilised bio-polymers in DDS’s manufacturing.…”

Section: Introductionmentioning

confidence: 99%

“…DEX is biosynthesised intra- or extracellularly by lactic acid bacteria (LAB), which represent one of the most important microbial groups due to their roles in food fermentations and synthesis of techno-functional metabolites [ 27 ]. By virtue of its properties, DEX has been used for over 50 years as a circulatory volume expander, in order to improve blood flow [ 13 ] and prevent postoperative deep-vein thrombosis [ 16 ]. It has also been used in anaemia treatment or as an antiviral agent, being selective for various viruses [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Dextran Formulations as Effective Delivery Systems of Therapeutic Agents

Petrovici¹,

Pinteala²,

Simiónescu

2023

Molecules

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Dextran is by far one of the most interesting non-toxic, bio-compatible macromolecules, an exopolysaccharide biosynthesized by lactic acid bacteria. It has been extensively used as a major component in many types of drug-delivery systems (DDS), which can be submitted to the next in-vivo testing stages, and may be proposed for clinical trials or pharmaceutical use approval. An important aspect to consider in order to maintain high DDS’ biocompatibility is the use of dextran obtained by fermentation processes and with a minimum chemical modification degree. By performing chemical modifications, artefacts can appear in the dextran spatial structure that can lead to decreased biocompatibility or even cytotoxicity. The present review aims to systematize DDS depending on the dextran type used and the biologically active compounds transported, in order to obtain desired therapeutic effects. So far, pure dextran and modified dextran such as acetalated, oxidised, carboxymethyl, diethylaminoethyl-dextran and dextran sulphate sodium, were used to develop several DDSs: microspheres, microparticles, nanoparticles, nanodroplets, liposomes, micelles and nanomicelles, hydrogels, films, nanowires, bio-conjugates, medical adhesives and others. The DDS are critically presented by structures, biocompatibility, drugs loaded and therapeutic points of view in order to highlight future therapeutic perspectives.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dextran Formulations as Effective Delivery Systems of Therapeutic Agents

Petrovici¹,

Pinteala²,

Simiónescu

2023

Molecules

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“…The above-mentioned results indicate that MK alkalinization exhibits silica chain breakage. The spatial charge density profiles 55 and regional changes of Si and Al ions are obtained in Figure 8, but the change of ion density cannot be directly acquired. Therefore, the charge density profiles were used to measure the charge density changes of Si and Al ions in the alkalized MK system (with Na) and nonalkalized MK system (without Na).…”

Section: ■ Introductionmentioning

confidence: 99%

Molecular Insights into the Reaction Process of Alkali-Activated Metakaolin by Sodium Hydroxide

et al. 2022

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When metakaolin (MK) is alkalized with an alkaline activator, it depolymerizes under the action of the alkali. However, the process of MK alkalinization is still unrevealed. Here, we supplied a molecular insight into the process of MK alkalinization through reaction molecular dynamics (MD) simulation. The structure, dynamics, and process of MK alkalinization are systematically investigated. The results showed that the layered structure of MK was destroyed and the silicates in MK were dissolved by sodium hydroxide solution during the alkalinization reaction of MK. The aluminates in MK are not dissolved, indicating that aluminates are more stable than silicates. Moreover, the equilibrium structures of MK with H 2 O and MK with NaOH solution show that only when both sodium hydroxide and water are involved in the alkalinization reaction, the silicates in MK undergo depolymerization. Also, the observed final state of MK alkalinization can be recognized as the precursor of alkali-activated materials (AAMs).

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“…Polyelectrolyte intrinsic properties such as molecular weight and charge density also have some effect on film growth behavior. [21][22][23] In addition to ionic strength and polyelectrolyte intrinsic properties the deposit solution pH has already found to be an important parameter to controlling polyelectrolyte conformation in solution 24 and on the surface 25 as well as adjusting PEM film growth behavior. [26][27][28][29] Poly(allylamine hydrochloride)/poly(acrylic acid) (PAH/PAA) films made of two weak polyelectrolytes may probably among the first films being investigated with respect to pH variations.…”

Section: Introductionmentioning

confidence: 99%

“…Thicker film always assures larger drug loading capacity, and this is a strikingly important parameter for sustainable drug release. Polyelectrolyte intrinsic properties such as molecular weight and charge density also have some effect on film growth behavior 21–23 . In addition to ionic strength and polyelectrolyte intrinsic properties the deposit solution pH has already found to be an important parameter to controlling polyelectrolyte conformation in solution 24 and on the surface 25 as well as adjusting PEM film growth behavior 26–29 .…”

Section: Introductionmentioning

confidence: 99%

pH responsive, reversible photo‐crosslinkable micelle in layer‐by‐layer assembly—Study on film growth and drug delivery behavior

Song

Jin

et al. 2022

Journal of Polymer Science

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Layer-by-layer multilayered film has been creating great opportunities in developing controlled drug and other bioactive molecular delivery system. In this work, coumarin bearing micelles of poly(acrylic acid-coumarin methacrylate) is first synthesized in a one-step copolymerization and the reversible photo-crosslinkable multilayers containing coumarin groups are then fabricated via layering the micelles with polyethyleneimine (PEI). The film growth behavior of polyetheleneimine/poly(acrylic acid-coumarin methacrylate) (PEI/P(AA-r-CMA)) multilayer is found to rely on deposit solution pH. Increasing PEI solution pH and decreasing P(AA-r-CMA) pH can greatly accelerate film growing process. This is explained by PEI diffusivity and destabilization of P(AA-r-CMA) micelle at solution/multilayer interface. Nile red (NR) is loaded into the film as a model drug via simple post diffusion driven by hydrophobic interactions. Furthermore, photo-crosslink and decrosslink of PEI/P(AA-r-CMA) film is achieved by irradiating the films with light of 365 and 254 nm wavelength, respectively, which therefore ensures the possibility of fine control over drug delivery procedure.

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Dextran-based polyelectrolyte multilayers: Effect of charge density on film build-up and morphology

Cited by 8 publications

References 72 publications

Dextran Formulations as Effective Delivery Systems of Therapeutic Agents

Dextran Formulations as Effective Delivery Systems of Therapeutic Agents

Molecular Insights into the Reaction Process of Alkali-Activated Metakaolin by Sodium Hydroxide

pH responsive, reversible photo‐crosslinkable micelle in layer‐by‐layer assembly—Study on film growth and drug delivery behavior

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