Dextran-b-poly(L-histidine) copolymer nanoparticles for pH-responsive drug delivery to tumor cells

Hwang, Jong-Ho; Choi, Cheol Woong; Kim, Hyung‐Wook; Kim, Do-Hyung; Kwak, Tae Won; Lee, Hye Myeong; Kim, Cy Hyun; Chung, Chung Wook; Jeong, Young-II; Kang, Dae Hwan

doi:10.2147/ijn.s49459

Cited by 13 publications

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“…Nanomedicine such as nanoparticles, liposomes and polymeric micelles have advantages in targeting malignant solid tumor because they have small sizes of <1000 nm and unique structures that can amplify the anticancer activity of conventional drugs [ 22 – 27 ]. In recent decades, nanomedicine-based drug delivery systems have also been investigated to target CCA cells for diagnosis and chemotherapeutic treatment [ 22 – 27 ]. Magnetic nanoparticles were reported to be a useful device for the diagnosis of intrahepatic CCA [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

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Antitumor activity of vorinostat-incorporated nanoparticles against human cholangiocarcinoma cells

et al. 2015

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BackgroundThe aim of this study is to evaluate the anticancer activity of vorinostat-incorporated nanoparticles (vorinostat-NPs) against HuCC-T1 human cholangiocarcinoma cells. Vorinostat-NPs were fabricated by a nanoprecipitation method using poly(dl-lactide-co-glycolide)/poly(ethylene glycol) copolymer.ResultsVorinostat-NPs exhibited spherical shapes with sizes <100 nm. Vorinostat-NPs have anticancer activity similar to that of vorinostat in vitro. Vorinostat-NPs as well as vorinostat itself increased acetylation of histone-H3. Furthermore, vorinostat-NPs have similar effectiveness in the suppression or expression of histone deacetylase, mutant type p53, p21, and PARP/cleaved caspase-3. However, vorinostat-NPs showed improved antitumor activity against HuCC-T1 cancer cell-bearing mice compared to vorinostat, whereas empty nanoparticles had no effect on tumor growth. Furthermore, vorinostat-NPs increased the expression of acetylated histone H3 in tumor tissue and suppressed histone deacetylase (HDAC) expression in vivo. The improved antitumor activity of vorinostat-NPs can be explained by molecular imaging studies using near-infrared (NIR) dye-incorporated nanoparticles, i.e. NIR-dye-incorporated nanoparticles were intensively accumulated in the tumor region rather than normal one.ConclusionsOur results demonstrate that vorinostat and vorinostat-NPs exert anticancer activity against HuCC-T1 cholangiocarcinoma cells by specific inhibition of HDAC expression. Thus, we suggest that vorinostat-NPs are a promising candidate for anticancer chemotherapy in cholangiocarcinoma.Graphical abstractLocal delivery strategy of vorinostat-NPs against cholangiocarcinomas.

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Section: Introductionmentioning

confidence: 99%

“…In our previous study, chitosan nanoparticles incorporating all-trans retinoic acid were demonstrated to be effective in inhibiting the invasion, migration and proliferation of human CCA cells [ 26 ]. Stimuli-sensitive nanoparticles can also be considered to target CCA cells [ 27 ].…”

Section: Introductionmentioning

confidence: 99%