Dexrazoxane for anthracycline extravasation and GM-CSF for skin ulceration and wound healing

Saghir, M. Ziad; Otrock, Zaher K.; Mufarrij, Afif; Mourad, Yasser Abou; Salem, Ziad; Shamseddine, Ali; Abbas, Jaber

doi:10.1016/s1470-2045(04)01470-6

Cited by 57 publications

(20 citation statements)

References 9 publications

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“…Several similar studies have also had encouraging results and the doses used have varied between 30 [15] and 400 lg [16,17] and 10 lg cm À2 . More recently, some authors have used topical GM-CSF successfully for treating cutaneous ulcers [11,18].…”

Section: Discussionmentioning

confidence: 99%

Recombinant granulocyte-macrophage colony-stimulating factor in the treatment of indolent ulcers with Klippel-Trénaunay-Weber syndrome: a case report

Siddiqui¹,

Mokhashi²,

Boathman³

2007

Journal of Pediatric Surgery

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Section: Discussionmentioning

confidence: 99%

Recombinant granulocyte-macrophage colony-stimulating factor in the treatment of indolent ulcers with Klippel-Trénaunay-Weber syndrome: a case report

Siddiqui¹,

Mokhashi²,

Boathman³

2007

Journal of Pediatric Surgery

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“…The findings were later supported by a number of published clinical case reports [5][6][7][8], and the three-day schedule became the model for the succeeding clinical treatment.…”

Section: Preclinical Experimentsmentioning

confidence: 67%

Other uses of dexrazoxane: savene, the first proven antidote against anthracycline extravasation injuries

2007

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Dexrazoxane has been in clinical use for more than 25 years for prevention of cardiotoxicity in anthracycline based anticancer therapy. However, we discovered another property of the compound, i.e. the ability to prevent the devastating tissue necrosis after accidental extravasation of anthracyclines. The preclinical and clinical studies leading to the clinical implementation of Savene (dexrazoxane) as the first and only proven antidote in anthracycline extravasation are described in short.

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“…It is not approved for adjuvant and curative treatment protocols with DOX, because all studies with dexrazoxane were performed in the metastatic setting, and it is not yet certain whether the antitumor effect of DOX is reduced when used in combination with ICRF-187. A number of case reports [8,9] as well as animal studies [4] on the use of dexrazoxane in cases of extravasation have been published showing promising results. Furthermore, the effects of dexrazoxane have been discussed in relation to the mechanism of action of anthracyclines acting as a topoisomerase II (topo II) poison.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Anthracycline Extravasation with Dexrazoxane – Clinical Experience

Frost¹,

Gmehling²,

Azémar³

et al. 2006

Oncol Res Treat

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Accidental extravasation is a severe complication when administering anthracyclines. We describe 3 cases of extravasation with 3 different anthracyclines. Patients and Methods: One patient came from another hospital for a second opinion after an epirubicin extravasation. Only surgical debridement of the necrotic tissue was possible. The other two extravasations occurred during treatment with doxorubicin and doxorubicin- EMCH, respectively, in our department. Both patients were treated with dexrazoxane within 6 h of the event. Results: The 2 patients treated with dexrazoxane recovered completely without any sequelae. Conclusions: Treatment of antracycline extravasation with dexrazoxane is potentially useful and safe.

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Dexrazoxane for anthracycline extravasation and GM-CSF for skin ulceration and wound healing

Cited by 57 publications

References 9 publications

Recombinant granulocyte-macrophage colony-stimulating factor in the treatment of indolent ulcers with Klippel-Trénaunay-Weber syndrome: a case report

Recombinant granulocyte-macrophage colony-stimulating factor in the treatment of indolent ulcers with Klippel-Trénaunay-Weber syndrome: a case report

Other uses of dexrazoxane: savene, the first proven antidote against anthracycline extravasation injuries

Treatment of Anthracycline Extravasation with Dexrazoxane – Clinical Experience

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