Dexmedetomidine Reduces the Ischemia-Reperfusion Injury Markers During Upper Extremity Surgery With Tourniquet

Yağmurdur, Hatice; Özcan, Namık; Dokumaci, Fatma; Kılınç, Kamer; Yılmaz, Fatma Meriç; Başar, Hülya

doi:10.1016/j.jhsa.2008.01.014

Cited by 50 publications

(56 citation statements)

References 37 publications

(38 reference statements)

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“…In this study also the MDA levels in the dexmedetomidine group was lower than that in the control group [33]. In a recent study where the effect of dexmedetomidine was searched to decrease I/R injury due to tourniquet application for upper limb surgery, the MDA values in the dexmedetomidine group was significantly lower in respect to control group during the reperfusion phase [34].…”

Section: Discussionsupporting

confidence: 47%

The Effect of Dexmedetomidine and Propofol on Oxidative Stress and Antioxidizing System Studied on Liver Ischemia-reperfusion Model on Rats

Urfalıoğlu¹,

Cantürk²,

Akçaboy³

et al. 2013

J Anesthe Clinic Res

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Surgical procedureAnesthesia was induced with Ketamine to rats, (Ketalar flk, Eczacıbaşı) with a dose of 90 mg/kg. Under sterile cover, laporatomy was performed via midline incision. Hepatoduodenal ligament was Materials and methods: 24 rats were randomly divided into four groups. Following anesthesia laparotomy was done and hepatoduodenal ligament was explorated. Tissue samples were taken for both biochemical (MDA, SOD, GPx) and histological study.Results: MDA level was hisghest in Group II and was significantly lower in Group III and Group IV. GPx level was lowest in Group II, the level of GPx was higher in Group III and Group IV with respect to Group II. SOD level was lowest in Group II and was highest in Group IV. SOD levels in Group II and Group III did not show statistical significance. In the histopathological study, in Group I the liver parenchyme and membrane integrity was protected; in Group II the hepatocyte cellular membrane integrity was distorted, microvesicule number increased and the liver sinusoids were shrunken; in Group III the hepatocyte membrane and nucleus was near normal and well protected; and in Group IV the cellular component structures were protected, hepatocyte cell membrane was protected in normal thickness. Discussion:The results show that dexmedetomidine and propofol decrease the level of MDA in similarly; the effect of dexmedetomidine on GPx level was slightly lower than propofol and its effect on SOD level was lower than propofol. As a result, we believe that either propofol or dexmedetomidine can be effective in protecting hepatocytes from I/R injury especially in log term procedures but the former drug having dominance in this protective role.

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Section: Discussionsupporting

confidence: 47%

The Effect of Dexmedetomidine and Propofol on Oxidative Stress and Antioxidizing System Studied on Liver Ischemia-reperfusion Model on Rats

Urfalıoğlu¹,

Cantürk²,

Akçaboy³

et al. 2013

J Anesthe Clinic Res

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“…Yagmurdur et al showed that Dex significantly attenuated plasma hypoxanthine, malondialdehyde, creatine phosphokinase, and uric acid levels in upperextremity surgery. 41 On the other hand, in another study in lower extremity surgeries Dex was found to be ineffective in reducing the effects of tourniquet-induced ischemia-reperfusion injury during general anesthesia. 42 Studies focusing on the renoprotective effects of Dex have gained popularity in recent years but their effects are shown to be eliminated by a2-adrenoreceptor antagonists.…”

Section: Discussionmentioning

confidence: 98%

Curcumin and dexmedetomidine prevents oxidative stress and renal injury in hind limb ischemia/reperfusion injury in a rat model

et al. 2016

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Curcumin and dexmedetomidine have been shown to have protective effects in ischemia-reperfusion injury on various organs. However, their protective effects on kidney tissue against ischemia-reperfusion injury remain unclear. We aimed to determine whether curcumin or dexmedetomidine prevents renal tissue from injury that was induced by hind limb ischemia-reperfusion in rats. Fifty rats were divided into five groups: sham, control, curcumin (CUR) group (200 mg/kg curcumin, n ¼ 10), dexmedetomidine (DEX) group (25 lg/kg dexmedetomidine, n ¼ 10), and curcumin-dexmedetomidine (CUR-DEX) group (200 mg/kg curcumin and 25 lg/kg dexmedetomidine). Curcumin and dexmedetomidine were administered intraperitoneally immediately after the end of 4 h ischemia, just 5 min before reperfusion. The extremity re-perfused for 2 h and then blood samples were taken and total antioxidant capacity (TAC), total oxidative status (TOS) levels, and oxidative stress index (OSI) were measured, and renal tissue samples were histopathologically examined. The TAC activity levels in blood samples were significantly lower in the control than the other groups (p < 0.01 for all comparisons). The TOS activity levels in blood samples were significantly higher in Control group and than the other groups (p < 0.01 for all comparison). The OSI were found to be significantly increased in the control group compared to others groups (p < 0.001 for all comparisons). Histopathological examination revealed less severe lesions in the sham, CUR, DEX, and CUR-DEX groups, compared with the control group (p < 0.01). Rat hind limb ischemia-reperfusion causes histopathological changes in the kidneys. Curcumin and dexmedetomidine administered intraperitoneally was effective in reducing oxidative stress and renal histopathologic injury in an acute hind limb I/R rat model. ARTICLE HISTORY

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“…DEX, which is a highly selective ␣ 2 -agonist with analgesic, anesthetic and sedative effects, has been shown to have an antioxidant activity on several tissues [5][6][7][8][9] . Previous studies reported that DEX was effective in protecting from focal cerebral ischemia [20][21][22] and incomplete forebrain ischemia [23] in rats and rabbits.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, it was also reported that DEX alters gene expression induced by cerebral ischemia and it prevents late ischemic neural death [24] . Asides from cerebral ischemia models, it has been reported that DEX has a cardioprotective effect on isolated rat heart global ischemia model [7] , and it decreases I/R injury induced by tourniquet use during upper arm surgery in humans [6] . However, there is no evidence in the published literature regarding the administration of the DEX in a rat model of testicular T/DT.…”

Section: Discussionmentioning

confidence: 99%

“…Dexmedetomidine (DEX) is a highly selective and potent ␣ 2 -adrenergic agonist that is increasingly used as an adjunct in general anesthesia [5] . DEX can inhibit lipid peroxidation in cell membranes following I/R injury of various tissues [6][7][8][9] . However, to the best of our knowledge, DEX usage has not been investigated in the testicular I/R injury model.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Dexmedetomidine on Testicular Torsion/Detorsion Damage in Rats

Hancı

Erol²,

Bektaş³

et al. 2010

Urol Int

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Background and Objective: We assessed the antioxidant activity of dexmedetomidine (DEX) during an ischemic period in a rat model of testicular torsion/detorsion (T/DT) by using biochemical and histopathological methods. Methods: Wistar Albino male rats weighing 250–300 g were divided into three groups: sham (group S, n = 7); torsion/detorsion (group T/DT, n = 7), and DEX treatment (group DEX, n = 7). In the T/DT group, right testes were rotated 720° for 1 h. Group S served for normal basal values. Rats in group T/DT were operated to make T/DT, this group served as a control group. Group DEX received intraperitoneal DEX 10 µg · kg^–1 after the 30-min torsion period. For measurement of total antioxidant enzyme activities and malondialdehyde (MDA) levels, testes of 7 animals in each group were excised after 4 h of reperfusion. Germ cell apoptosis was evaluated using the apoptosis protease-activating factor 1 (APAF-1) antibody in all groups and also on the expressions of endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS) were assessed within the bilateral testes. Results: Mean MDA levels in group T/DT were significantly higher than in groups S and DEX (p < 0.05). There were also significant decreases in mean total antioxidant activities in group T/DT when compared to groups S and DEX (p < 0.05). These values were significantly higher in group DEX than group T/DT. Germ cell apoptosis, eNOS and iNOS levels were significantly higher in group T/DT when compared to groups S and DEX (p < 0.05). Conclusions: DEX treatment has potential biochemical and histopathological benefits by preventing ischemia/reperfusion-related cellular damage in an experimental testicular torsion model. Preference of DEX for anesthesia during the detorsion procedure may attenuate ischemia-reperfusion injury.

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Dexmedetomidine Reduces the Ischemia-Reperfusion Injury Markers During Upper Extremity Surgery With Tourniquet

Cited by 50 publications

References 37 publications

The Effect of Dexmedetomidine and Propofol on Oxidative Stress and Antioxidizing System Studied on Liver Ischemia-reperfusion Model on Rats

The Effect of Dexmedetomidine and Propofol on Oxidative Stress and Antioxidizing System Studied on Liver Ischemia-reperfusion Model on Rats

Curcumin and dexmedetomidine prevents oxidative stress and renal injury in hind limb ischemia/reperfusion injury in a rat model

Effect of Dexmedetomidine on Testicular Torsion/Detorsion Damage in Rats

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