Dexmedetomidine reduces IL-4 and IgE expression through downregulation of theTLR4/NF-κB signaling pathway to alleviate airway hyperresponsiveness in OVA mice

Zhi, Juan; Duan, Qirui; Wang, Qian yu; Du, Xiyu; Yang, Dong

doi:10.1016/j.pupt.2022.102147

Cited by 1 publication

(1 citation statement)

References 26 publications

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“…For instance, midazolam, propofol and ketamine have a direct relaxant effect on the isolated airway smooth muscle of dogs [ 126 ], and etomidate and propofol had a reduced histamine-induced contraction in isolated human airway smooth muscle [ 125 ]. Dexmedetomidine attenuated airway hyperresponsiveness and airway inflammatory responses through the TLR4/NFκB signaling pathway in ovalbumin-induced allergy model rats [ 127 ].…”

Section: Behavioral Characteristics Of Respiration Are Modulated By G...mentioning

confidence: 99%

The Modulation by Anesthetics and Analgesics of Respiratory Rhythm in the Nervous System

Hao

Yang

Liu

et al. 2024

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Rhythmic eupneic breathing in mammals depends on the coordinated activities of the neural system that sends cranial and spinal motor outputs to respiratory muscles. These outputs modulate lung ventilation and adjust respiratory airflow, which depends on the upper airway patency and venti- latory musculature. Anesthetics are widely used in clinical practice worldwide. In addition to clinically necessary pharmacological effects, respiratory depression is a critical side effect induced by most gen- eral anesthetics. Therefore, understanding how general anesthetics modulate the respiratory system is important for the development of safer general anesthetics. Currently used volatile anesthetics and most intravenous anesthetics induce inhibitory effects on respiratory outputs. Various general anes- thetics produce differential effects on respiratory characteristics, including the respiratory rate, tidalvolume, airway resistance, and ventilatory response. At the cellular and molecular levels, the mechanisms underlying anesthetic-induced breathing depression mainly include modulation of synaptictransmission of ligand-gated ionotropic receptors (e.g., γ-aminobutyric acid, N-methyl-D-aspartate,and nicotinic acetylcholine receptors) and ion channels (e.g., voltage-gated sodium, calcium, and po-tassium channels, two-pore domain potassium channels, and sodium leak channels), which affect neu-ronal firing in brainstem respiratory and peripheral chemoreceptor areas. The present review compre-hensively summarizes the modulation of the respiratory system by clinically used general anesthetics,including the effects at the molecular, cellular, anatomic, and behavioral levels. Specifically, analgesics, such as opioids, which cause respiratory depression and the “opioid crisis”, are discussed. Finally, underlying strategies of respiratory stimulation that target general anesthetics and/or analgesics aresummarized.

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Section: Behavioral Characteristics Of Respiration Are Modulated By G...mentioning

confidence: 99%

The Modulation by Anesthetics and Analgesics of Respiratory Rhythm in the Nervous System

Hao

Yang

Liu

et al. 2024

View full text Add to dashboard Cite

show abstract

Dexmedetomidine reduces IL-4 and IgE expression through downregulation of theTLR4/NF-κB signaling pathway to alleviate airway hyperresponsiveness in OVA mice

Cited by 1 publication

References 26 publications

The Modulation by Anesthetics and Analgesics of Respiratory Rhythm in the Nervous System

The Modulation by Anesthetics and Analgesics of Respiratory Rhythm in the Nervous System

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