Dexmedetomidine promotes NREM sleep by depressing the neuronal activity of OXT neurons in the PVN
Ying Zhang,
Jiaxin Li,
Wei Wang
et al.
Abstract:This study aimed to investigate the mechanism of Dexmedetomidine (DEX) on sleep homeostasis. We will focus on the effect of DEX on the activity and the signal transmission of oxytocin-expressing (Oxytocin, OXT) neurons in the paraventricular nucleus (PVN) of the hypothalamus (PVNOXT) in the regulation of sleep-wakefulness cycle. In this study, the guide cannula was implanted to microinject DEX into PVN. PVNOXT neurons were specifically activated by the chemogenetic method. Differences in sleep-wakefulness stat… Show more
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