Dexmedetomidine is an Excellent Additive to Local Anaesthesia for Postoperative Analgesia in Bilateral Third Molar Teeth Extraction Surgery

Abstract

Background: Extraction is still the primary treatment of choice for impact tooth under IANB or GA or a combination of both. Dexmedetomidine has been noticed to lengthen nerve blocks' range of duration, possibly due to the consequent vasoconstriction if combined with local anaesthetics. Aim of the work: This study investigates the effect of injection of Dexmedetomidine as an additive to Lidocaine in IAN for patients undergoing lower bilateral impacted tooth extraction regarding analgesia's overall quality. Patients and Methods: Sixty patients were randomized; 30 patients were in Group D and the other 30 in Group A. IANP was done bilaterally after GA using Lidocaine with Dexmedetomidine or Adrenaline. The primary outcome was the overall quality of analgesia and the whole demanded amount of analgesia. Hemodynamic parameters, patients and surgeon's satisfaction were recognized as secondary outcomes. Result: The mean duration of local anaesthesia and postoperative analgesia time in Group (D) is (259.0±11.5 min) and (362.3±12.3 min), which is higher than Group (A) (180.7±13.1) and (231.4±13.1). 83.3% of Group (D) received no analgesics, and 16.7% received one dose, while in Group (A), 50% received two doses, 33.3% received one dose, and 16.7% received no doses. VAS score was lower for Group (D) than (A) except for zero. The satisfaction was higher in Group (D) for both the patients and the surgeons. Conclusion: Adding 12.5μ/ml of Dexmedetomidine is an excellent additive to Lidocaine regarding the overall quality of analgesia, patient and surgeon satisfaction postoperatively.

Prevention of Dexmedetomidine on Postoperative Delirium and Early Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Thoracoscopic Lobectomy

“…As a new imidazole derivative, dexmedetomidine has high selectivity for α2 receptor and could effectively activate α2 receptor [25]. Pharmacological studies have suggested that its biological potency is better than clonidine.…”

Comparative Analysis of Anaesthetic Efficacy of 2% Lignocaine With Dexmedetomidine as an Adjunct in Nerve Blocks for Dental Extractions: A Randomised Controlled Study

“…These findings are by a study by Singh et al [ 8 ]. The effect of DEXMED can be attributed to its local vaso-constrictive and anti-inflammatory effects; these effects may be responsible for prolonged anesthesia and good analgesia post-operatively [ 12 - 15 ]. Yamane et al [ 4 ] also found similar results when dexmedetomidine was injected locally in the oral mucosa.…”