Dexmedetomidine in Aesthetic Facial Surgery: Improving Anesthetic Safety and Efficacy

Taghinia, Amir H.; Shapiro, Fred E.; Slavin, Sumner A.

doi:10.1097/01.prs.0000293867.05857.90

Cited by 60 publications

(44 citation statements)

References 41 publications

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“…In accordance with Gurbet et al [16] who stated that intraoperative infusion of dexmedetomidine reduces perioperative analgesic requirements. Also the analgesic effects of dexmedetomidine had been appreciated in various setting and various populations [17][18][19]. Our results showed that the sensory block was significantly prolonged in the dexmedetomidine group in comparison to the control group, which confirm that the intrathecal doses of dexmedetomidine used in our study prolonged the sensory block.…”

Section: Discussionsupporting

confidence: 79%

Bupivacaine-Dexmedetomidine for Lumber Discectomy: Randomized Controlled Placebo Study

Mohamed¹,

Salem²

2015

J Anesth Clin Res

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Section: Discussionsupporting

confidence: 79%

Bupivacaine-Dexmedetomidine for Lumber Discectomy: Randomized Controlled Placebo Study

Mohamed¹,

Salem²

2015

J Anesth Clin Res

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“…Walker et al [23] found that no respiratory depression associated with the use of dexmedetomidine had occurred. Taghinia et al [24] also reported that dexmedetomidine decreases the frequency of oxygen desaturation and reduces the amounts of narcotic and anxiolytic requirement. In this study, we did not observe any respiratory depression, hypoxia, or apnoea in any patient.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, 2 patients (6.66%) experienced nausea, but none had vomiting. Taghinia et al [24] have reported that dexmedetomidine use is associated with decreased use of antiemetics.…”

Section: Discussionmentioning

confidence: 99%

Use of Dexmedetomidine Infusion With Subanaesthetic Dose of Ketamine for Minor Surgical Procedures: A Study

Singha¹,

Pathak²,

Phukan³

et al. 2016

jemds

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BACKGROUNDDexmedetomidine, an α2 agonist is an approved drug for sedation and co-analgesia, but may cause hypotension and bradycardia. Ketamine, which provides profound analgesia and dissociative anaesthesia when used with dexmedetomidine may counteract the adverse haemodynamic effects as both have opposing actions on the cardiovascular system apart from providing satisfactory sedation and analgesia during minor surgical procedures.

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“…Uyanık karotis endarterektomisi sırasında, servikal pleksus bloğu altında, deksmedetomidin ile sedatize edilen hastaların intraoperatif analjezik gereksinimlerinin midazolam ve fentanil kullanılan gruptan daha az olduğu belirtilmiştir (18). Benzer şekilde, yüze uygulanan plastik cerrahi girişimlerinde sedasyon için deksmedetomidin alan hastalarda, geleneksel sedatif ajanlarla kıyaslandığında daha az intraoperatif narkotik ve midazolam ihtiyacı ortaya çıkmıştır (19).…”

Section: Discussionunclassified

“…Propofol ile karşılaştırıldığında, deksmedetomidin ile sağlanan sedasyonun, çocuk ve erişkinlerde arter oksijen satürasyonunu daha iyi koruduğu gözlenmiştir (19,22).…”

Section: Discussionunclassified

Comparison of Dexmedetomidine and Midazolam in Sedation for Percutaneous Hepatic Hydatid Cyst Drainage

Bavullu¹,

Aksoy²,

Abdullayev³

et al. 2013

Turk J Anesth Reanim

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Özgün Araştırma / Original Article 195Objective: Hydatid cyst still continues to be a public health problem. The basic treatment for the disease is surgery, but USG-guided percutaneous drainage has become an important treatment alternative. Agents preferred for sedation during drainage performed under local anaesthesia must also preserve respiration and haemodynamic stability while providing adequate sedation. We used midazolam, which has a short duration of action, and a selective α 2 adrenergic receptor agonist, dexmedetomidine, and compared them regarding their sedative properties and intraoperative complications. Methods:After approval by the clinical trials ethics committee, 40 patients with similar demographic data were randomized into two groups. All patients received 10 mg metochlopramide and 45.5 mg phenyramine before the procedure. Then midazolam (0.07 mg kg -1 iv bolus followed by 0.01 mg kg -1 h -1 infusion) was administered to Group 1, and dexmedetomidine (1 µg kg -1 loading dose in 10 minutes, followed by 0.2 µg kg -1 h -1 continuous infusion) was administered to Group 2 for sedation. Just before the surgical procedure, all patients received propofol in a subhypnotic dose of 0.5 mg kg -1 iv. Propofol 0.5 mg kg -1 iv was administered to patients in each group if there was no adequate sedation. OAA/S and BIS scales were used to evaluate the sedation level during the procedure. HR, MAP, RR, SpO 2 and ETCO 2 values were monitored before and after induction and every 5 minutes thereafter. The propofol requirement was noted for each group.Results: Sedation in the dexmedetomidine group was as effective and adequate as that observed with the midazolam group. BIS values were significantly low in the dexmedetomidine group, especially after 10 minutes and thereafter. Respiratory rate, SpO 2 , and ETCO 2 values were similar in both groups, whereas clinically insignificant decreases in HR and MAP were observed in the dexmedetomidine group. Propofol requirements were similar in both groups. Conclusion:We conclude that dexmedetomidine can be an appropriate agent in surgical procedures performed under local anaesthesia, providing adequate sedation without respiratory depression.Key Words: Dexmedetomidine, midazolam, sedation Amaç: Kist hidatik hala önemli bir sağlık sorunu olmaya devam etmektedir. Temel tedavisinin cerrahi olması ile birlikte, günümüzde ultrasonografi eşliğinde yapılan perkütan drenaj da önemli bir tedavi alternatifi haline gelmiştir. Lokal anestezi altında yapılan bu işlem sırasında, sedasyon için tercih edilecek ajanlar, hastada yeterli sedasyonu sağlamanın yanı sıra solunumu ve hemodinamiyi en az düzeyde etkileyecek özellikte olmalıdır. Çalışmamızda kısa etkili bir benzodiazepin olan midazolamı ve α 2 selektif adrenerjik reseptör agonisti deksmedetomidini kullanarak, bu ajanları sedasyon derinliği ve intraoperatif komplikasyonlar açısından karşılaştırdık.Yöntemler: Etik kurul onayı ve hasta onamı alındıktan sonra demografik verileri benzer 40 hasta, randomize iki gruba ayrıldı. İşlem öncesi her...

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Dexmedetomidine in Aesthetic Facial Surgery: Improving Anesthetic Safety and Efficacy

Abstract: Dexmedetomidine lowered blood pressure, decreased the frequency of oxygen desaturations, and reduced narcotic, anxiolytic, and antiemetic use. When compared with conventional sedation, dexmedetomidine appears to improve anesthetic safety and efficacy for rhytidectomy patients.

Cited by 60 publications

References 41 publications

Bupivacaine-Dexmedetomidine for Lumber Discectomy: Randomized Controlled Placebo Study

Bupivacaine-Dexmedetomidine for Lumber Discectomy: Randomized Controlled Placebo Study

Use of Dexmedetomidine Infusion With Subanaesthetic Dose of Ketamine for Minor Surgical Procedures: A Study

Comparison of Dexmedetomidine and Midazolam in Sedation for Percutaneous Hepatic Hydatid Cyst Drainage

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