Dexmedetomidine attenuates remote lung injury induced by renal ischemia‐reperfusion in mice

Abstract

Dexmedetomidine is capable of attenuating remote lung injury induced by renal IR via both α(2) adrenoceptors dependent and independent mechanisms.

Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial

“…The underlying mechanism for dexmedetomidine's hypoxaemia-sparing action was not directly investigated; preclinical studies highlight its pulmonary protective eff ect after remote organ injury. 35 However, this apparent eff ect could also just be a coincident signifi cant fi nding and warrants further study. Dexmedetomidine can provide analgesia by acting on the α 2 adrenergic receptors in the spinal cord.…”

The effect of dexmedetomidine against oxidative and tubular damage induced by renal ischemia reperfusion in rats

“…13,14 During the TNF-a renal I/R, the macrophages, leukocytes and proinflammatory released from renal tubular cells are cytokines. 15 According to a study carried out by Gu et al 16 in mice, it has been reported that after kidney I/R, dex reduces the levels of myeloperoxidase (MPO) in the lung tissue, inter-cellular adhesion molecule (ICAM-1) and TNF-a mRNA. In another study, it has been determined that dex reduces the level of MDA and increases the level of GSH after hepatic I/R.…”

Molecular targets and mechanism of action of dexmedetomidine in treatment of ischemia/reperfusion injury (Review)

“…As a main result, kidney tissue examined histopathologically following 45 min reperfusion exhibited decreased injury. Gu et al (83) found that significant injury developed in lungs of rats following renal I/R, and that DEX (25 mg/kg) administered intraperitoneally prior to and following ischemia, effectively prevented the damage (69).…”