Abstract:Background
Anesthesia and surgery can induce perioperative neurocognitive disorders (PND). Mitochondrial dysfunction has been proposed to be one of the earliest triggering events in surgery-induced neuronal damage. Dexmedetomidine has been demonstrated to attenuate the impairment of cognition in aged rats induced by surgery in our previous study.
Methods
Male Sprague-Dawley rats underwent hepatic apex resection under anesthesia with propofol to cli… Show more
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